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Found 28 clinical trials
A Safety Extension Study of Ontamalimab in Participants With Moderate to Severe Ulcerative Colitis or Crohn's Disease (AIDA)

The purpose of this study is to evaluate the safety and tolerability of long-term treatment with ontamalimab in participants with moderate to severe Ulcerative Colitis (UC) or Crohn's disease

remission
colitis
flexible sigmoidoscopy
endoscopy
ulcerative colitis
  • 1349 views
  • 15 Aug, 2021
  • 827 locations
A Study to Evaluate the Effect of Ustekinumab on Cytochrome P450 Enzyme Activities Following Induction and Maintenance Dosing in Participants With Active Crohn's Disease or Ulcerative Colitis

The purpose of this study is to evaluate the potential effects of an intravenous (IV) induction and subcutaneous (SC) maintenance administration of ustekinumab on the pharmacokinetic (PK) of a cocktail of representative probe substrates of cytochrome P450 (CYP) enzymes (CYP3A4, CYP2C9, CYP2C19, CYP2D6, and CYP1A2) in participants with Active Crohn's …

colitis
vitamin
ileocolitis
endoscopy
ulcerative colitis
  • 110 views
  • 06 Sep, 2021
  • 26 locations
Clinical Database of Colorectal Robotic Surgery

Evaluation of robot Da Vinci Xi by determining its learning curve.The operating time will be defined by patient then the operating average will be calculated.

low anterior resection
cancer
colitis
ulcerative colitis
colorectal neoplasm
  • 1 views
  • 28 Jun, 2021
  • 5 locations
A Master Protocol (AMAZ): A Study of Mirikizumab (LY3074828) in Pediatric Participants With Ulcerative Colitis or Crohn's Disease (SHINE-ON)

The main purpose of this study is to evaluate the long-term efficacy of mirikizumab in pediatric participants with ulcerative colitis (UC) or Crohn's disease (CD). The study will last about 172

colitis
crohn's disease
mirikizumab
ulcerative colitis or crohn's
ulcerative colitis
  • 0 views
  • 12 Sep, 2021
  • 7 locations
A Study of Intravenous Vedolizumab Administered Every 4 Weeks in Japanese Participants With Moderate to Severe Ulcerative Colitis or Crohn's Disease

The main aim of the study is to learn if 4-weekly vedolizumab improves symptoms of Japanese participants with moderate to severe ulcerative colitis (UC) or Crohn's disease (CD). Vedolizumab is

colitis
endoscopy
ulcerative colitis
hematochezia
ulceration
  • 0 views
  • 19 Sep, 2021
  • 18 locations
A Study to Evaluate the Effect of Intravenous (IV) Infusions of Risankizumab on Pharmacokinetics of Cytochome P450 Substrates in Adult Participants With Moderately to Severely Active Ulcerative Colitis or Crohn's Disease

Ulcerative colitis (UC) is a type of inflammatory bowel disease that causes inflammation and bleeding from the lining of the rectum and colon (large intestine).Crohn's disease (CD) is a long-lasting condition causing inflammation that can affect any part of the gut. CD may cause tiredness, loose stools with or without …

immunomodulators
colitis
abdominal pain
vitamin
ulcerative colitis
  • 113 views
  • 31 Aug, 2021
  • 7 locations
Transcutaneous VNS to Treat Pediatric IBD

The current available therapies for inflammatory bowel disease (IBD), including immunomodulator and biologic medications may have toxicities limiting use or inadequate effect. We propose a novel approach to the treatment of IBD by using transcutaneous vagal nerve stimulation (VNS). Research has previously identified that VNS using a surgically implanted stimulator …

cytokines
colitis
faecal calprotectin
vedolizumab
prednisone
  • 0 views
  • 12 Sep, 2021
  • 1 location
Characterization of the Intestinal Microbiota in Patients With Inflammatory Bowel Disease and/or Spondyloarthritis and Study of the Impact of an Anti-TNF Alpha Therapy

Spondyloarthritis and inflammatory bowel diseases are common diseases, frequently met together in overlap syndromes. Their physiopathology remains puzzling. A strong role of gut microbiota has been recently put forward to explain the development of inflammatory bowel diseases, and is suspected to play an important role in rheumatoid diseases. Anti-Tumor Necrosis …

tumor necrosis factor
colitis
overlap syndromes
ulcerative colitis
ulceration
  • 6 views
  • 29 Apr, 2021
  • 2 locations
Special Physical Exercises as a Therapeutic Intervention for Inflammatory Bowel Disease

The investigator is hypothesize that physical activity can have positive effects on health, general well-being , sleep quality and stress in Inflammatory Bowel Disease patients.

enteropathy
immunomodulators
mesalamine
intestinal diseases
inflammatory bowel disease
  • 1 views
  • 24 Jan, 2021
  • 1 location
NIR FME of Labelled Vedolizumab to Elucidate the Mechanism of Action and Predicting Response in IBD Patients.

Summary Vision Study Crohn's Disease (CD) and Ulcerative Colitis (UC) are chronic idiopathic inflammatory bowel diseases (IBD). Vedolizumab is a humanized monoclonal antibody against 47 integrin, capable of blocking the migration of several immune cells across endothelium expressing MAdCAM-1. Vedolizumab is expensive and primary non-response is high in both CD …

  • 0 views
  • 10 May, 2021
  • 1 location