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Found 425 clinical trials
TDM for Optimized Outcome in Patients With mRCC.

The purpose of this observational study is to assess the role of plasma concentration monitoring of treatment drugs for patients with metastatic renal cell carcinoma (mRCC) in terms of efficacy and side effects. Furthermore, the investigators intend to evaluate the role of anti-drug antibodies, amount of bound drug to T …

  • 27 Jan, 2021
  • 3 locations
Surgery in Gastrointestinal Stromal Tumors (GISTs) for Treatment Tumor Modeling and Genomic Analysis

Objective To follow people with GISTs and collect tumor tissue so that it can be studied in the lab. Eligibility People age 6 and older who have a GIST. Design Participants will be screened with a review of their medical records and samples. Participants will enroll in 1 other NIH …

ct scan
  • 12 Sep, 2021
  • 1 location
Collecting and Storing Tissue From Young Patients With Cancer

This laboratory study is collecting and storing tissue, blood, and bone marrow samples from young patients with cancer. Collecting and storing samples of tissue, blood, and bone marrow from patients with cancer to study in the laboratory may help doctors learn more about changes that may occur in DNA and …

acute lymphoblastic leukemia (all)
myeloid leukemia
ewing sarcoma/peripheral primitive neuroectodermal tumor
rhabdoid tumor
  • 26 Jan, 2021
  • 26 locations
EUS Guided Cyanoacrylate Injection vs Endoscopic Variceal Band Ligation for Prevention of Rebleeding in Patients With Hepatocellular Carcinoma and Esophageal Variceal Bleeding

SP by EUS-CYA improves clinical outcomes (eg, EV rebleeding) in patients with HCC and prior EV bleeding when compared with SP by EGD-VBL

  • 17 Aug, 2021
  • 1 location
Skeletal Muscle Mitochondrial Abnormalities and the Metabolic Syndrome in PAH

Pulmonary arterial hypertension (PAH) is characterized by the progressive increase in pulmonary vascular resistance ultimately leading to right ventricular (RV) failure. Its prevalence is estimated at 40-60 persons per million and predominantly affects people between 20 and 60 years of age. Newly available therapies have improved the 3-year survival to …

  • 08 Sep, 2021
  • 1 location
Surgical Treatment of Pancreatic Metastases From Renal Cell Carcinoma

Pancreatic metastases are a rare entity. In cases of metastatic renal carcinoma (RCC) it can present as isolated pancreatic metastasis, considering the possibility of surgical resection. Goals Define survival after resection of pancreatic cancer metastases renal in a wide range of our country. Identify predictive survival factors Methods Retrospective multicenter …

  • 26 Jan, 2021
  • 2 locations
Front-line Treatment of BCR-ABL+ Chronic Myeloid Leukemia (CML) With Dasatinib

The GIMEMA CML Working Party promotes a multicentric, observational, non company sponsored, prospective study of Chronic Myeloid Leukemia (CML) patients treated frontline with dasatinib. Patients will be followed for 5 years. This study will help the definition of guidelines for the treatment of CML patients in early phases. The primary …

  • 22 Aug, 2021
  • 38 locations
Natural History Study of Children and Adults With Medullary Thyroid Cancer

Background Medullary thyroid cancer (MTC) is a rare cancer of the thyroid gland. In children and adults, it is often part of a condition called Multiple Endocrine Neoplasia 2 (MEN2). MEN2 is usually caused by a genetic mutation, and it can cause a number of problems in addition to MTC. …

  • 12 Sep, 2021
  • 1 location
Study of Plasma NGS for Assessment Characterization Evaluation of Patients With ALK Resistance

ALK-positive lung cancer is a subtype of lung cancer which carries a change in a gene called ALK (anaplastic lymphoma kinase). There are now many drugs for patients with ALK-positive lung cancer that slow cancer growth. However, after some time, just as bacteria evolve resistance to antibiotics, ALK-positive lung cancers …

lung carcinoma
liquid biopsy
  • 01 Aug, 2021
The Role of Lymphangiogenesis in Head and Neck Cancer Metastasis

The purpose of this study is to investigate the role of lymphangiogenesis in the metastasis of head and neck cancer.

squamous cell carcinoma
squamous cell carcinoma of the head and neck
neck cancer
head and neck cancer
  • 07 Nov, 2020