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Found 141 clinical trials
A Biospecimen Collection Study in BRAF-V600E Mutated Recurrent Gliomas

This is a surgical biospecimen collection study. The purpose of this study is to understand how much of two drugs (dabrafenib and trametinib) are able to penetrate brain tumors and turn off the RAF signaling pathway. This is important because these drugs are currently FDA approved for other tumors and …

astrocytoma, anaplastic
primary brain tumors
brain tumor
trametinib
pleomorphic xanthoastrocytoma
  • 28 views
  • 11 May, 2022
  • 3 locations
Postoperative Pain in Patients Undergoing Scheduled Laparoscopic Intestinal Resection Surgery (TAP)

This observational prospective study aims to evaluate the postoperative analgesic effect of a regional anesthesia thechnique (TAP block) in patients undergoing scheduled laparoscopic intestinal resection for intestinal cancer. ASA I-III patients operated between May 1 and September 30, 2019 under general anesthesia according to usual clinical practice, will be included. …

  • 0 views
  • 09 May, 2022
  • 1 location
ZOOMit-fMRI Identifies Motor Functional Cortex

This study was designed to collect a series of patients with gliomas which were involved in motor cortex to analyze difference accuracy of motor cortex localization between BOLD-fMRI and ZOOMit-fMRI.

MRI
  • 4 views
  • 24 Feb, 2022
  • 1 location
The βIG-H3 Protein: a New Marker in PANCreatic Adenocarcinoma (BIGHPANC) (BIGHPANC)

The primary objective of this trial is to evaluate the correlation between the intensity of the protein big-h3 expression at tumoural microenvironment and the TNM/UICC staging (from I to IV) of pancreatic adenocarcinoma lesion.

  • 3 views
  • 05 Mar, 2022
  • 1 location
Assessment of Eloquent Function in Brain Tumor Patients

Purpose of the study: AIM 1 Prospectively collect pre-operative (fMRI, DTI, MEG) and intra-operative mapping data in patients with intra-axial brain tumors to assess how well each modality predicts the location of eloquent brain function. In addition, each modality will be compared with the other. AIM 2 Assess reorganization of …

brain tumor
  • 8 views
  • 17 May, 2022
  • 1 location
Immune Checkpoints in Colorectal Cancer

Colorectal cancer (CRC) ranked the first in cancer incidence in Hong Kong and it is frequently lethal with heterogeneous drug responses and survival outcomes. Immune-based approaches targeting to enhance tumor-specific responses have been actively under investigation as therapeutic strategies. Currently, PD1 and PD-L1 blockade has shown promising results in clinical …

  • 0 views
  • 15 Feb, 2021
  • 1 location
Surgery in Gastrointestinal Stromal Tumors (GISTs) for Treatment, Tumor Modeling, and Genomic Analysis

Objective To follow people with GISTs and collect tumor tissue so that it can be studied in the lab. Eligibility People age 6 and older who have a GIST. Design Participants will be screened with a review of their medical records and samples. Participants will enroll in 1 other NIH …

ct scan
  • 0 views
  • 01 Jul, 2022
  • 1 location
Perioperative Evaluation of Cerebellar Tumors

This is a prospective, cohort study to evaluate the impact of cerebellar functional topography on perioperative outcomes related to cognition and motor ataxia in patients with cerebellar tumors.

  • 0 views
  • 24 Mar, 2022
  • 1 location
BIOhabitats: Biological Validation of Vascular Habitats Within Astrocytoma Grade 4 at Molecular, Cellular, and Histopathological Levels (BIOhabitats)

The main purposes of this study are: I. To assess that the four habitats within the tumor (HAT and LAT) and edema (IPE and VPE) in high-grade glioma are different at vascular, tissular, cellular and molecular levels. II. To analyze the associations between the perfusion imaging markers and relevant molecular …

  • 0 views
  • 25 May, 2022
Tumor Related Epilepsy

Background Some people with brain tumors have seizures related to the tumor. This is called tumor-related epilepsy. Usually brain tumors are treated by removing as much of the brain tumor as possible without causing problems. Researchers think this may improve the outcome for people with brain tumors. It may completely …

recurrent brain tumors
brain surgery
neurologic examination
electroencephalogram
seizure
  • 24 views
  • 28 Jun, 2022
  • 1 location