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Found 276 clinical trials
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A Phase III study of the Efficacy and Safety of subjects with Moderately to Severe active Rheumatoid Arthritis which have been inadequately controlled by Tumor Necrosis Factor Alpha (TNF-a) inhibitor therapy

A Phase III study of the Efficacy and Safety of subjects with Moderately to Severe active Rheumatoid Arthritis which have been inadequately controlled by Tumor Necrosis Factor Alpha (TNF-a) inhibitor

  • 302 views
  • 08 Nov, 2020
  • 1 location
featured
A Phase III, randomized, double-blind, placebo controlled, multicenter study to evaluate the efficacy and safety of Etrolizumab as an induction and maintenance treatment for patients with moderately to severe active Crohn's Disease.

A Phase III, randomized, double-blind, placebo controlled, multicenter study to evaluate the efficacy and safety of Etrolizumab as an induction and maintenance treatment for patients with moderately to severe active Crohn's Disease.

  • 180 views
  • 08 Nov, 2020
  • 1 location
featured
A Phase III, Randomized, Double-blind, Placebo-controlled Study of Subcutaneous Secukinumab in Autoinjectors, to Demonstrate Efficacy at 24 Weeks and Long Term Safety and Efficacy up to 3.5 Years in Subjects With Active Psoriatic Arthritis

A Phase III, Randomized, Double-blind, Placebo-controlled Study of Subcutaneous Secukinumab in Autoinjectors, to Demonstrate Efficacy at 24 Weeks and Long Term Safety and Efficacy up to 3.5 Years in Subjects With Active Psoriatic Arthritis

  • 2362 views
  • 23 Nov, 2020
  • 18 locations
Clinical Study of Anti-tumor Necrosis Factor Therapy in Patients With Takayasu Arteritis

Clinical study of anti-tumor necrosis factor therapy in patients with Takayasu arteritis. This study is single arm (anti Tumor necrosis factor therapy only) clinical trial. Enrolled

tumor necrosis factor
tumor necrosis factor alpha
tumor necrosis
  • 0 views
  • 08 Nov, 2020
Low Dose Oral Methotrexate in Pediatric Crohn's Disease Patients Initiating Anti-Tumor Necrosis Factor (Anti-TNF) Therapy

The purpose of this study is to determine whether adding low dose methotrexate to anti -TNF therapy is more effective than treatment with anti-TNF therapy alone in inducing and maintaining steroid-free remission for children with Crohn's Disease.

  • 91 views
  • 07 May, 2020
  • 37 locations
Tumor Necrosis Factor (TNF) and Glucocorticoid Antagonist for Gulf War Illness (GWI)-Associated Multi-symptom Disease Homeostasis Reset

Gulf War Illness is a condition that affects multiple major organ systems, resulting in a diverse array of symptoms that include debilitating fatigue, memory and cognition difficulties, headaches, sleep disturbances, gastrointestinal problems, skin rashes, and musculoskeletal/joint pain. This phase I single-site, open-label two-arm study will assess the safety and mechanistic …

  • 0 views
  • 07 May, 2020
  • 1 location
Sequential Application of Yisaipu and DMARDs in Treating Mild-to-Moderate AS

The drug regimes in treating ankylosing spondylitis(AS) have limitations. The tumor necrosis factor inhibitors(TNFi) was effective but expensive. Disease modifying anti-rheumatic drugs (DMARDs

tumour necrosis
hydroxychloroquine
DMARD
tumor necrosis factor
anti-rheumatic drugs
  • 24 views
  • 08 Nov, 2020
  • 1 location
Evaluation of the Safety Tolerability and Efficacy of MDGN-002 in Adults With Moderate to Severe Active Crohn's Disease

adults with moderate to severe, active Crohn's disease who have previously failed anti-tumor necrosis factor alpha (anti-TNF) treatment.

tumour necrosis
tumor necrosis factor alpha
endoscopy
tumor necrosis factor
monoclonal antibodies
  • 170 views
  • 08 Nov, 2020
  • 4 locations
Genetic Polymorphisms of TNF- Promoter and HBV Genotype on Outcome of HBV-Related Chronic Liver Disease

contribute to disease severity. Cytokine gene polymorphism has been regarded affecting prognosis of disease. By detecting HBV genotyping and tumor necrosis factor-alpha polymorphism, this study

carcinoma
hepatitis
tumor necrosis factor
liver disease
hepatocellular carcinoma
  • 0 views
  • 07 Nov, 2020
  • 1 location
Ankylosing Spondylitis and Antiphospholipid Antibodies

determine whether the presence of APLA is more frequent in patients receiving anti-tumor necrosis factor (TNF) alpha therapy.

tumor necrosis factor
tumor necrosis factor alpha
tumour necrosis
  • 86 views
  • 08 Nov, 2020
  • 1 location