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Found 50 clinical trials
Biological Characterisation of High Risk CHildhood Cancer in Children, Adolescents and Young Adults (MICCHADO) (MICCHADO)

Methodology Prospective, multicentric, open, non-randomised, non-therapeutic, interventional study

metastatic osteosarcoma
mycn
histological diagnosis
metastatic neuroblastoma
kidney tumors
  • 30 views
  • 16 Mar, 2022
  • 13 locations
Effects of Carvedilol on Cardiotoxicity in Cancer Patients Submitted to Anthracycline Therapy

failure) are related to the use of anthracyclines. Anthracyclines are part of the chemotherapy regimen for solid tumors and hematological neoplasms in children and adults, and are associated with an

primary cancer
anthracyclines
treatment regimen
  • 0 views
  • 08 Oct, 2021
  • 1 location
INFORM2 Study Uses Nivolumab and Entinostat in Children and Adolescents With High-risk Refractory Malignancies (INFORM2 NivEnt)

The aim of this trial is to determine preliminary activity of the combination treatment with nivolumab and entinostat in children and adolescents with high risk refractory/relapsed/progressive tumors harboring a high mutational load, high PD-L1 mRNA expression or focal MYC(N) amplification and explore activity in biomarker low tumors (low mutational load, …

medulloblastoma
dipg
solid tumour
diffuse intrinsic pontine glioma
ependymoma
  • 0 views
  • 22 Jul, 2022
  • 14 locations
EXOme Rare Cancers in Children (EXOCARE) (EXOCARE)

Other than high-dose radiation and previous chemotherapy, few strong risk factors have been identified as causes of childhood cancer. Geneticists estimate that 5 to 10% of all cancers diagnosed during the paediatric period occur in children born with a genetic mutation, increasing their lifetime risk of neoplasia. Such genetic risk …

  • 0 views
  • 11 Aug, 2022
  • 18 locations
Fimepinostat in Treating Brain Tumors in Children and Young Adults (PNOC016)

This trial studies how well fimepinostat works in treating patients with newly diagnosed diffuse intrinsic pontine glioma, or medulloblastoma, or high-grade glioma that have come back. Fimepinostat may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth.

medulloblastoma
glomerular filtration rate
neutrophil count
dexamethasone
monoclonal antibodies
  • 3 views
  • 23 Jul, 2022
  • 21 locations
EGFR806 CAR T Cell Immunotherapy for Recurrent/Refractory Solid Tumors in Children and Young Adults

This is a phase I, open-label, non-randomized study that will enroll pediatric and young adult research participants with relapsed or refractory non-CNS solid tumors to evaluate the safety, feasibility, and efficacy of administering T cell products derived from the research participant's blood that have been genetically modified to express a …

antibody therapy
cancer chemotherapy
stem cell infusion
apheresis
viral therapy
  • 484 views
  • 13 May, 2022
  • 1 location
B7H3 CAR T Cell Immunotherapy for Recurrent/Refractory Solid Tumors in Children and Young Adults

This is a phase I, open-label, non-randomized study that will enroll pediatric and young adult research participants with relapsed or refractory non-CNS solid tumors to evaluate the safety, feasibility, and efficacy of administering T cell products derived from the research participant's blood that have been genetically modified to express a …

antibody therapy
cancer chemotherapy
stem cell infusion
apheresis
mibg
  • 39 views
  • 11 May, 2022
  • 1 location
CAR T Cells After Lymphodepletion for the Treatment of IL13Rα2 Positive Recurrent or Refractory Brain Tumors in Children

This phase I trial investigates the side effects of chemotherapy and cellular immunotherapy in treating children with IL13Ralpha2 positive brain tumors that have come back after a period of improvement (recurrent) or do not respond to treatment (refractory). Cellular immunotherapy (IL13(EQ)BBzeta/CD19t+ T cells) are brain-tumor specific cells that may induce …

bevacizumab
neutrophil count
chemotherapy drug
malignant brain tumor
temozolomide
  • 0 views
  • 09 Jun, 2022
  • 1 location
  • 0 views
  • 26 Jan, 2021
  • 1 location
Screening With Whole Body MRI For Detection Of Primary Tumors In Children And Adults With Li-Fraumeni Syndrome (LFS) And Other Cancer Predisposition Syndromes

This study is evaluating Whole Body MRI as a possible screening tool to diagnose cancer for people with LFS and other inherited cancer predisposition syndromes.

  • 20 views
  • 21 Mar, 2022
  • 2 locations