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Found 39 clinical trials
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Biological Characterisation of High Risk CHildhood Cancer in Children Adolescents and Young Adults (MICCHADO)

Methodology Prospective, multicentric, open, non-randomised, non-therapeutic, interventional study

cancer
mycn protein
brain tumor
kidney tumors
sarcoma
  • 30 views
  • 23 Jan, 2021
  • 28 locations
None
Effects of Carvedilol on Cardiotoxicity in Cancer Patients Submitted to Anthracycline Therapy

failure) are related to the use of anthracyclines. Anthracyclines are part of the chemotherapy regimen for solid tumors and hematological neoplasms in children and adults, and are associated with an

anthracyclines
primary cancer
treatment regimen
  • 0 views
  • 08 Oct, 2021
  • 1 location
None
European Proof-of-Concept Therapeutic Stratification Trial of Molecular Anomalies in Relapsed or Refractory Tumors

The first molecular profiling protocols have been launched in Europe (MOSCATO-01 (Geoerger 2014), MAPPYACTS, INFORM, iTHER, SM-PAEDS, etc.) determining multiple actionable alterations in pediatric recurrent cancers. Increasingly, stratified approaches are being implemented to enrich clinical trials of molecularly targeted agents and possibly improve outcomes in specific populations i.e. a molecularly …

  • 38 views
  • 06 Mar, 2021
  • 8 locations
None
EXOme Rare Cancers in Children (EXOCARE)

Other than high-dose radiation and previous chemotherapy, few strong risk factors have been identified as causes of childhood cancer. Geneticists estimate that 5 to 10% of all cancers diagnosed during the paediatric period occur in children born with a genetic mutation, increasing their lifetime risk of neoplasia. Such genetic risk …

  • 0 views
  • 04 Apr, 2021
  • 24 locations
None
Fimepinostat in Treating Brain Tumors in Children and Young Adults

This trial studies how well fimepinostat works in treating patients with newly diagnosed diffuse intrinsic pontine glioma, or medulloblastoma, or high-grade glioma that have come back. Fimepinostat may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth.

dexamethasone
brain tumor
astrocytoma
growth factor
corticosteroids
  • 3 views
  • 13 Aug, 2021
  • 19 locations
None
Pilot Study of Cabozantinib for Recurrent or Progressive Central Nervous System Tumors in Children

This pilot will study the feasibility and exploratory efficacy of using Cabozantinib for recurrent or refractory central nervous system tumors for which there are no curative options. Patients will also be followed for safety, time to progression, event free survival and overall survival

biologics
cancer
astrocytoma
platelet count
anticonvulsants
  • 32 views
  • 02 Sep, 2021
  • 1 location
None
EGFR806 CAR T Cell Immunotherapy for Recurrent/Refractory Solid Tumors in Children and Young Adults

This is a phase I, open-label, non-randomized study that will enroll pediatric and young adult research participants with relapsed or refractory non-CNS solid tumors to evaluate the safety, feasibility, and efficacy of administering T cell products derived from the research participant's blood that have been genetically modified to express a …

recurrent disease
solid tumor
chemotherapy regimen
mibg
biologic agent
  • 308 views
  • 30 Apr, 2021
  • 1 location
None
B7H3 CAR T Cell Immunotherapy for Recurrent/Refractory Solid Tumors in Children and Young Adults

This is a phase I, open-label, non-randomized study that will enroll pediatric and young adult research participants with relapsed or refractory non-CNS solid tumors to evaluate the safety, feasibility, and efficacy of administering T cell products derived from the research participant's blood that have been genetically modified to express a …

recurrent disease
solid tumor
chemotherapy regimen
mibg
biologic agent
  • 0 views
  • 27 Apr, 2021
  • 1 location
None
CAR T Cells After Lymphodepletion for the Treatment of IL13R 2 Positive Recurrent or Refractory Brain Tumors in Children

This phase I trial investigates the side effects of chemotherapy and cellular immunotherapy in treating children with IL13Ralpha2 positive brain tumors that have come back after a period of improvement (recurrent) or do not respond to treatment (refractory). Cellular immunotherapy (IL13(EQ)BBzeta/CD19t+ T cells) are brain-tumor specific cells that may induce …

tumor cells
nervous
temozolomide
karnofsky performance status
cyclophosphamide
  • 0 views
  • 27 May, 2021
  • 1 location
None
  • 0 views
  • 26 Jan, 2021
  • 1 location