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Found 84 clinical trials
Effect of Neoadjuvant or Adjuvant Systemic Therapy on Breast Cancers, Bone Marrow Cancer Cells, and Circulating Cancer Cells

The main purpose of this study is to compare genetic markers present on tumor cells before and after chemotherapy.

breast cancer
tumor cells
cancer
immunostimulant
  • 18 views
  • 23 Jan, 2022
  • 1 location
Cell-free DNA Quantification for Predictive Marker of Palliative Chemotherapy

This study is design to address, as follows: correlation between fluorescence-based CFD measurements and tumor burden (primary tumor size, number of metastatic sites) fluorescence-based CFD measurements and changes are related to tumor response. Based on the results of this study, the role of fluorescence-based CFD as a predictive biomarker for …

  • 0 views
  • 23 Mar, 2022
  • 1 location
Therapeutic ResistAnce and Clonal Evolution Assessed With Liquid Biopsy in ICIs Treated Primary Liver Cancer

To evaluate the predictive value of ctDNA in response, relapse for liver cancer patients treated with immune checkpoint inhibitors

measurable disease
cancer
  • 0 views
  • 29 Jun, 2022
  • 4 locations
The Culture of Advanced or Recurrent Ovarian Cancer Organoids and Drug Screening

Most ovarian cancer will relapse after standard therapy. Patients with recurrent ovarian cancer are resistant to platinum. Due to the high heterogeneity between ovarian cancer, individual precise therapy is of great importance. The study will establish ovarian cancer organoids, whose original tissues from the patients with advanced or recurrent ovarian …

cancer of the ovary
recurrent ovarian cancer
  • 0 views
  • 10 Apr, 2022
  • 1 location
Novel 3D Hematological Malignancy Organoid to Study Disease Biology and Chemosensitivity (Organoid)

The objective of this project is to compare chemosensitivity between chemotherapy combinations in bone marrow aspirates using 3D organoid models. The investigators overarching hypothesis is that 3D organoids are ideal to test chemosensitivity in real time, to provide personalized medicine and guidance in the setting of relapsed hematologic malignancy and …

chemotherapy regimen
hematologic malignancy
multiple myeloma
bone marrow procedure
cancer
  • 13 views
  • 10 Jul, 2022
  • 1 location
Pharmacodynamic Biomarkers of Standard Anti-microtubule Drugs as Assessed by Early Tumor Biopsy

Eligible subjects will be assigned to study treatment arms by their treating oncologist, rather than by the study. The drug, dose, and schedule of administration will be determined by the treating physician per NCCN guidelines for standard of care chemotherapy regimens for recurrent or metastatic breast cancer. Study treatment arms …

taxane
vinorelbine
antineoplastic
doxorubicin
cancer chemotherapy
  • 8 views
  • 28 Feb, 2022
  • 1 location
Molecular Profiling After Neoadjuvant Chemotherapy for Triple-negative Breast Cancer

Neoadjuvant chemotherapy (NACT) can induce complete pathologic response (pCR) in approximately 35-55% of patient with triple-negative breast cancer (TNBC). These patients have excellent long term survivals. On the other hand patients with residual disease exhibit a high rate of local or metastatic. Although it has been successful in some regards, …

mastectomy
erbb2
breast cancer
adjuvant chemotherapy
lumpectomy
  • 0 views
  • 05 Mar, 2022
  • 1 location
Dynamic Monitoring of ctDNA Methylation to Predict Relapse in Colorectal Cancer After Radical Resection

This is a prospective, multicenter, observational, single-blinded controlled study. Dynamic monitoring of patients with resectable colorectal cancer was performed using the previously established colorectal tumor-specific plasma ctDNA methylation markers (Multigene methylation detection). Dynamic monitoring of plasma ctDNA methylation before and after treatment and at regular follow-up in patients with colorectal …

colorectal neoplasm
  • 3 views
  • 25 May, 2022
  • 1 location
Observational Study of Factors Predicting Therapeutic Effects and Clinical Prognosis After HAIC for Locally Advanced HCC

Prospective single arm, single center observational study to evaluate factors which were easily available from preoperative examination for predicting therapeutic effects and clinical prognosis of hepatic artery infusion chemotherapy (HAIC) for hepatocellular carcinoma. There factors are collected in preoperative routine blood examination, preoperative radiological imaging and pathological examination. Patients which …

renal function
measurable disease
platelet count
neutrophil count
pet scan
  • 0 views
  • 15 Jun, 2022
  • 1 location
Rediscovering Biomarkers for the Diagnosis and Early Treatment Response in NEN (REBORN)

This is a multicentre, controlled, observational prospective study on new biomarkers, as immune profiling, angiogenetic markers and circRNA from TEPs in the diagnosis and in the evaluation of treatment response in pulmonary and gastro-entero-pancreatic NENs.

  • 0 views
  • 27 Jan, 2021
  • 1 location