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Found 86 clinical trials
A Study to Assess the Efficacy and Safety of IMAB362 in Combination With Nab-Paclitaxel and Gemcitabine (Nab-P + GEM) as First Line Treatment in Subjects With Claudin 18.2 (CLDN18.2) Positive, Metastatic Pancreatic Adenocarcinoma

the combination treatment. This study will also evaluate tumor markers and pharmacokinetics (PK) of zolbetuximab, Nab-P and GEM, and health-related quality of life (HRQoL).

gemcitabine
metastatic pancreatic cancer
cancer chemotherapy
paclitaxel
blood transfusion
  • 250 views
  • 03 Jun, 2022
  • 80 locations
Gallium-68 PSMA-11 PET in Patients With Biochemical Recurrence

This study evaluates the value of Gallium-68 labeled PSMA (68Ga-PSMA) for PET/CT imaging of prostate cancer recurrence. 68Ga-PSMA is a radioactive molecule, which binds to prostate cancer cells. Together with a PET/CT scanner, the distribution of 68Ga-PSMA can be determined in the body. To test this new drug, participants will …

adenocarcinoma of prostate
ct scan
68ga-psma-11
prostatectomy
brachytherapy
  • 0 views
  • 26 Feb, 2022
  • 1 location
Intra-Operative Electron Boost and Hypofractionated Whole-Breast Irradiation During Breast-conserving Treatment (BCT)

Title HIOB - Hypofractionated Whole-Breast Irradiation preceded by Intraoperative Radiotherapy with Electrons as anticipated Boost ISIORT- 01 HIOB is defined as hypofractionated WBRT (40,5 Gy in 2,7 Gy per fraction) preceded by an Intraoperative Boost to the tumor bed ( 90 % reference dose of 10 Gy, 11,1 Gy Dmax …

cancer
breast irradiation
carcinoma
breast cancer
  • 0 views
  • 28 Dec, 2021
  • 1 location
COLLISION Trial - Colorectal Liver Metastases: Surgery vs Thermal Ablation

The primary objective is to prove non-inferiority of thermal ablation compared to hepatic resection in patients with at least one resectable and ablatable colorectal liver metastases (3cm) and no extrahepatic disease.

liver metastasis
metastasis
  • 33 views
  • 23 Jan, 2021
  • 2 locations
A Clinical and Molecular Risk-Directed Therapy for Newly Diagnosed Medulloblastoma

Historically, medulloblastoma treatment has been determined by the amount of leftover disease present after surgery, also known as clinical risk (standard vs. high risk). Recent studies have shown that medulloblastoma is made up of distinct molecular subgroups which respond differently to treatment. This suggests that clinical risk alone is not …

brain tumor
medulloblastoma
residual tumor
corticosteroids
cyclophosphamide
  • 144 views
  • 25 May, 2022
  • 1 location
Testing the Addition of 131I-MIBG or Lorlatinib to Intensive Therapy in People With High-Risk Neuroblastoma (NBL)

This phase III trial studies iobenguane I-131 or lorlatinib and standard therapy in treating younger patients with newly-diagnosed high-risk neuroblastoma or ganglioneuroblastoma. Radioactive drugs, such as iobenguane I-131, may carry radiation directly to tumor cells and not harm normal cells. Lorlatinib may stop the growth of tumor cells by blocking …

isotretinoin
high-risk neuroblastoma
topotecan
stem cell transplantation
etoposide
  • 117 views
  • 01 Jul, 2022
  • 97 locations
S1703 Serum Tumor Marker Directed Disease Monitoring in Patients With Hormone Receptor Positive Her2 Negative Metastatic Breast Cancer

This randomized research trial studies how well serum tumor marker directed disease monitoring works in monitoring patients with hormone receptor positive Her2 negative breast cancer that has spread to other places in the body. Using markers to prompt when scans should be ordered may be as good as the usual …

  • 246 views
  • 16 Feb, 2022
  • 495 locations
PRECISE CURATE.AI Pilot Clinical Trial

solid tumours. An additional objective is to explore tumour markers in serial measurements at weekly frequency of probing, with modulated doses.

neutrophil count
capecitabine
  • 0 views
  • 22 Mar, 2022
  • 2 locations
Open D3 Right Hemicolectomy Compared to Laparoscopic CME for Right Sided Colon Cancer

circulating tumor DNA (ctDNA) and circulating tumor cells (CTCs) and evaluate their value as tumor markers by comparing the prognostic and predictive value. The hypothesis is that ctDNA and CTCs are more

colon cancer
anesthesia
right hemicolectomy
cancer
circulating tumor cells
  • 0 views
  • 04 Sep, 2021
  • 1 location
Early Detection of Prostate Cancer (PROLIPSY)

classic peripheral tumour markers, such as Prostate Health Index (PHI) and PCA3. Follow up evaluations will be initiated to assess the prognostic relevance of the candidate biomarkers determined in this

  • 0 views
  • 25 Mar, 2022