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Found 52 clinical trials
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A Phase III, Randomized, Double-blind, Placebo-controlled Study of Subcutaneous Secukinumab in Autoinjectors, to Demonstrate Efficacy at 24 Weeks and Long Term Safety and Efficacy up to 3.5 Years in Subjects With Active Psoriatic Arthritis

A Phase III, Randomized, Double-blind, Placebo-controlled Study of Subcutaneous Secukinumab in Autoinjectors, to Demonstrate Efficacy at 24 Weeks and Long Term Safety and Efficacy up to 3.5 Years in Subjects With Active Psoriatic Arthritis

  • 2412 views
  • 23 Nov, 2020
  • 18 locations
A Study of Guselkumab and Golimumab Combination Therapy in Participants With Active Psoriatic Arthritis (AFFINITY)

prior anti-tumor necrosis factor-alpha (anti-TNF-alpha) therapy by assessing clinical response compared with guselkumab monotherapy.

adalimumab
psoriasis
polyarticular arthritis
biosimilar
arthritis mutilans
  • 5 views
  • 02 May, 2022
  • 27 locations
Radiofrequency Perineural Injection Idiopathic Carpal Tunnel Syndrome

procedure, one week ,two month and four months after procedure except SNCV and serum CRP and TNF (tumor necrosis factor alpha)will be done before the procedure and after four months only):

nerve conduction
tingling sensation
Accepts healthy volunteers
conservative management
ultrasound guidance
  • 0 views
  • 06 Oct, 2021
  • 1 location
Topical Infliximab for Sterile Corneal Melt

necrolysis or mucous membrane pemphigoid. Infliximab is an antibody against tumour necrosis factor alpha and has been used to treat or prevent corneal melt in certain patients with inflammatory of

  • 8 views
  • 24 Feb, 2022
  • 1 location
Low Level Tragus Stimulation in Acute Decompensated Heart Failure (TREAT-HF)

of cytokines such as C-reactive protein (CRP), interleukin-1 (IL-1), interleukin-6 (IL-6), interleukin-10 (IL-10) and Tumor Necrosis Factor alpha (TNFα) in patients with heart failure (HF). Increased

acute heart failure
vagal stimulation
cytokines
  • 0 views
  • 23 Feb, 2022
  • 1 location
Randomised Treatment of Acute Pancreatitis With Infliximab: Double-blind Multi-centre Trial (RAPID-I) (RAPID-I)

This study evaluates the effectiveness and safety of infliximab in the treatment of acute pancreatitis in adults. A third of participants will receive one single dose of infliximab via infusion, another third will receive a higher dose of infliximab via infusion and the final third of participants will receive a …

acute pancreatitis
abdominal pain
amylase
  • 6 views
  • 11 Mar, 2022
  • 1 location
ABY-035 in the Treatment of Subjects With Ankylosing Spondylitis

ABY-035-204 is a clinical study to assess the efficacy of IL-17 blocker ABY-035 in ankylosing spondylitis(AS). The primary objective is to estimate the relationship between different dose regimens of ABY-035 and clinical response as assessed by Assessment of Spondyloarthritis International Society 40 (ASAS40) response at Week 16 in subjects with …

NSAID
x-rays
  • 0 views
  • 05 Apr, 2022
An Explorative Psoriasis Biomarker Study

Plaque psoriasis may be an ideal model disease to explore potential therapeutic effects of immunosuppressive agents, given the easy accessibility of inflammatory lesions. In this study, the applicability of a systems dermatology approach is investigated in order to better assess the efficacy of psoriasis treatments at an early clinical stage. …

  • 0 views
  • 24 Jun, 2021
  • 1 location
Administration of Adipose-derived Stem Cells (ASC) in Patient With Critical Limb Ischemia

Different types of stem cells have recently been studied in clinical trial on ischemic disease of the heart and muscular arteries. Adipose derived stem cell, have shown in vitro and in vivo models a stronger potential of success in recovering from ischemic disease and oxygenation of the tissues. The investigators …

  • 0 views
  • 25 Jan, 2021
  • 2 locations
A Study of Vedolizumab in Children and Teenagers With Moderate to Severe Ulcerative Colitis (UC)

Vedolizumab is a medicine that helps to reduce inflammation and pain in the digestive system. In this study, children and teenagers with moderate to severe ulcerative colitis will be treated with vedolizumab. The main aim of the study is to check if participants achieve remission after treatment with vedolizumab. Remission …

vedolizumab
tumour necrosis
mercaptopurine
tumor necrosis factor alpha
tumor necrosis factor
  • 0 views
  • 24 Mar, 2022
  • 1 location