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Found 53 clinical trials
Intensified Tuberculosis Treatment to Reduce the Mortality of Patients With Tuberculous Meningitis (INTENSE-TBM)

treatment. Aspirin, compared to not receiving aspirin. The trial will be open-label for anti-TB treatment and placebo-controlled for aspirin treatment.

  • 2 views
  • 26 Jul, 2022
  • 10 locations
Study to Evaluate H56:IC31 in Preventing Rate of TB Recurrence

-negative adults with a diagnosis of drug susceptible pulmonary TB are planned to be included, recruited from TB clinics with established relationships to the trial sites at the start of their TB treatment

smear
  • 1 views
  • 07 Oct, 2021
  • 6 locations
A Clinical Risk Score for Early Management of TB in Uganda (PredicTB)

Although curative treatment exists, tuberculosis (TB) remains the leading cause of infectious mortality worldwide - often because people seek care for TB symptoms in highly resource-constrained clinics that cannot provide same-day diagnostic testing. The research team has developed an easy-to-use clinical risk score that, if implemented in these settings, might …

  • 0 views
  • 21 Mar, 2022
  • 1 location
Evaluation of a Rapid Point-of-Care Serological Triage Test for Active TB (SeroSelectTB)

The performance of a new triage test for active tuberculosis (TB), SeroSelectTB, will be qualified in multi-centre randomised controlled trials at health-posts in South Africa, Tanzania and Ethiopia. Cost effectiveness evaluations will be conducted to support a value proposition to stakeholders and regulatory authorities, and to support commercialization requirements. Consenting …

  • 2 views
  • 13 Jun, 2022
  • 1 location
Atorvastatin to Reduce Inflammation After Tuberculosis Treatment Completion

successful TB treatment completion in HIV-infected and HIV-uninfected adults measured by PET/CT.

  • 0 views
  • 27 Jan, 2021
  • 1 location
The Individualized M(X) Drug-resistant TB Treatment Strategy Study (InDEX)

This is a randomized controlled clinical trial comparing treatment success of a gene-derived individualized drug-resistant Tuberculosis regimen to a standard Tuberculosis regimen based on South African National Tuberculosis guidelines.

probe
mycobacterium
extensively drug-resistant tuberculosis
rifampin
antiretroviral
  • 25 views
  • 28 Jul, 2022
  • 1 location
Refining MDR-TB Treatment (T) Regimens (R) for Ultra(U) Short(S) Therapy(T)

The purpose of this study is to assess the efficacy, safety and tolerability of a combination of levofloxacin, linezolid, cycloserine and pyrazinamide (or clofazimine if resistant to pyrazinamide) treatments for 24 to 32 weeks (regimen consisted of clofazimine for 36~44 weeks) in subjects with multidrug-resistant tuberculosis (MDR-TB) compared to WHO …

clofazimine
rifampin
pyrazinamide
pulmonary tuberculosis
linezolid
  • 0 views
  • 24 Jan, 2021
  • 13 locations
Drug Exposure and Safety of a Shorter Tuberculosis Treatment Based on High-Dose Rifampicin and Pyrazinamide

Tuberculosis (TB) treatment is long and complex with the risk of poor treatment adherence and treatment failure. Several attempts to shorten treatment of drug-susceptible TB have been

  • 0 views
  • 31 Aug, 2021
  • 1 location
Clinical Trial to Investigate Therapeutic Vaccine (RUTI) Against Tuberculosis (TB)

) patients favourably responding to standard MDR-TB treatment. Time point of vaccination starts upon completion of 1 week of standard DS-TB treatment (cohort A), and another cohort of patients will be

  • 0 views
  • 07 Apr, 2022
  • 1 location
Efficacy and Tolerability of Bedaquiline, Delamanid, Levofloxacin, Linezolid, and Clofazimine to Treat MDR-TB (DRAMATIC)

were diagnosed and started on treatment, reflecting inadequate diagnostic capacity and lack of TB treatment capacity. In this multicenter, randomized, partially blinded, four-arm, phase 2 study

  • 0 views
  • 10 Jul, 2022
  • 1 location