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Found 145 clinical trials
Cardiovascular Protection Conservative Effects of Esketamine Versus µ-opioid Receptor Agonists in General Anesthesia

the perioperative incidence of adverse cardiovascular events and alteration of cardiac troponin I (cTnI) in the patients (one thousand patients, ASA Physical Status 1-II, older than 16 years

  • 5 views
  • 02 May, 2022
  • 1 location
Breast Cancer Toxicity (CANTO)

The aims of the cohort will be to quantify impact of cancer treatments toxicities , and to generate predictors of chronic toxicity in patients with non-metastatic breast cancer. The project will include four specific aims : To develop a database of chronic treatment related toxicity in a cohort of 14750 …

Accepts healthy volunteers
  • 10 views
  • 19 Apr, 2022
  • 1 location
Italian Digital Primary Cardiovascular Prevention Study (CV-PREVITAL)

The CV-PREVITAL study is a randomised clinical trial (RCT) controlled versus usual-care designed to compare the effectiveness of a mobile health (mHealth) intervention with that of usual care in reducing specific cardiovascular (CV) risk factors (in the short term) and the occurrence of vascular events (in the long term). Promoted …

Accepts healthy volunteers
  • 0 views
  • 04 Oct, 2022
  • 29 locations
Hs-Troponin T Kinetics in Patients Treated With MCO Membranes Compared to High-flux, Low-flux Membranes and HDF

In this study, 24 prevalent hemodialysis patients will undergo four regular hemodialysis sessions during which four different treatments will be performed. Treatment 1: MCO membrane (=medium cut off) Treatment 2: low flux membrane Treatment 3: high flux membrane Treatment 4: HDF(=hemodiafiltration) treatment with high flux membrane So far, there is …

  • 0 views
  • 04 Oct, 2022
  • 1 location
Safety and Efficacy of Low Temperature Rota-flush Solution in Patients With Severe Calcified Lesion (LOTA-II) (LOTA-II)

reported that 58 consecutive patients with stable angina requiring PCI with RA to a calcified coronary lesion have 68% 5-fold increase in high sensitivity troponin after RA. The objective of this

single coronary artery
troponin
  • 0 views
  • 06 May, 2022
  • 9 locations
Multi-center, Open-label, Phase 1b Clinical Trial to Evaluate the Safety, Tolerability, and Exploratory Efficacy of TEW-7197 in Combination With FOLFOX in Patients With Metastatic Pancreatic Ductal Adenocarcinoma Who Have Failed First-Line Gemcitabine and Nab-Paclitaxel (MP-PDAC-01)

)and Doppler ECHO results at screening or within 14 days before screening Subjects who have increase in brain natriuretic peptide(BNP) or increase in troponin (over 99th percentile upper

paclitaxel
oxaliplatin
platelet count
metastatic pancreatic ductal adenocarcinoma
leucovorin
  • 1 views
  • 29 Jun, 2022
  • 1 location
Phase I Study of AZD5363 + Olaparib + Durvalumab in Patients With Advanced or Metastatic Solid Tumor Malignancies

This is a Phase 1 dose-escalation study to evaluate the safety and tolerability of combination treatment of AZD5363 + Olaparib + Durvalumab and to determine the RP2D in patients with advanced or metastatic solid tumor malignancies. The purpose of this trial is to determine if combination treatment of drugs, Olaparib, …

  • 0 views
  • 22 Jan, 2021
  • 1 location
Effect Levosimendan Administration on Postoperative NT-proBNP in Cardiac Risk Patients

This is a prospective randomised trial investigating the effect of a preemptive administration of levosimendan on postoperative cardiac NT-proBNP concentrations.

  • 0 views
  • 04 Oct, 2022
  • 1 location
Etiologic Mechanisms Myocardial Changes and Prognosis of Patients With MINOCA

This prospective trial will include 150 patients with myocardial infarction with non-obstructive coronary arteries (MINOCA). A thorough clinical, laboratory and imaging evaluation will be performed by novel biomarkers and modern imaging techniques (heart magnetic resonance imaging and noninvasive testing). Moreover, two different treatment groups will be distinguished. Additionally, a retrospective …

  • 0 views
  • 26 Jan, 2021
  • 1 location
Feasibility of Low Energy Diet in HFpEF and Type 2 Diabetes (ALLEVIATE)

Open, Single arm intervention, feasibility study

  • 0 views
  • 09 Jun, 2022
  • 1 location