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Found 464 clinical trials
Palbociclib and Binimetinib in Advanced Triple Negative Breast Cancer

advanced unresectable triple negative breast cancer with activation of ERK and/or CDK4/6 in which the following will be assesed: the overall response rate, the aggregation of antitumor effect depending on

mammogram
BRCA2
BRCA1
palbociclib
triple negative breast cancer
  • 0 views
  • 16 Sep, 2021
  • 8 locations
Imipramine on ER+ve and Triple Negative Breast Cancer

Comparing changes in biomarkers from a diagnostic core needle biopsy to surgical pathology specimen or repeat core needle biopsy.

carcinoma
core needle biopsy
ductal carcinoma
lobular carcinoma
triple negative breast cancer
  • 0 views
  • 22 Aug, 2021
  • 1 location
Olaparib and Durvalumab in Treating Patients With Metastatic Triple Negative Breast Cancer

This phase II study assesses the efficacy of the combination of olaparib and durvalumab in the treatment of patients with metastatic triple negative breast cancer (TNBC). Olaparib may stop

HER2
estrogen
erbb2
immunohistochemistry
triple negative breast cancer
  • 0 views
  • 16 Jun, 2021
  • 2 locations
A Study of Fruquintinib in Combination With Tislelizumab in Advanced Triple Negative Breast Cancer

This is an open-label, multi-center, non-randomized, Phase 1b/2 study to assess the safety and efficacy of fruquintinib in combination with tislelizumab in patients with advanced, refractory TNBC. This study will be conducted in 2 parts; a safety lead-in phase (Part 1) and a dose expansion phase (Part 2). The safety …

HER2
estrogen
cish
erbb2
immunohistochemistry
  • 0 views
  • 20 Jul, 2021
  • 3 locations
Oral Etoposide Combined With Anlotinib in Advanced Triple Negative Breast Cancer

clinical study of oral etoposide combined with antinib in the treatment of recurrent or metastatic triple-negative breast cancer

triple negative breast cancer
taxane
measurable disease
metastasis
  • 0 views
  • 02 Aug, 2021
  • 1 location
Trilaciclib in Patients Receiving Sacituzumab Govitecan-hziy for Triple Negative Breast Cancer

, locally advanced or metastatic triple-negative breast cancer (TNBC) who received at least 2 prior treatments, at least 1 in the metastatic setting.

HER2
taxane
mammogram
erbb2
triple negative breast cancer
  • 0 views
  • 19 Jan, 2022
  • 5 locations
Trilaciclib a CDK4/6 Inhibitor in Patients With Early-Stage Triple Negative Breast Cancer

early-stage triple negative breast cancer (TNBC). This study will have four phases: 1) Screening Phase, 2) Trilaciclib Lead-In Phase, 3) Treatment Phase, and 4) Surgery and Follow-Up Phase. After

carboplatin
cyclophosphamide
estrogen
paclitaxel
triple negative breast cancer
  • 0 views
  • 19 Jan, 2022
  • 1 location
Serial Circulating Tumor DNA (ctDNA) Monitoring During Adjuvant Capecitabine in Early Triple-negative Breast Cancer

The purpose of the study is to evaluate the use of a circulating tumor DNA (ctDNA) assay, ie, a "liquid biopsy," as a tool to identify triple-negative breast cancer (TNBC) patients who will or

estrogen
progesterone
capecitabine
mammogram
  • 0 views
  • 19 Jan, 2022
  • 1 location
Phase 2 Trial of Neoadjuvant Weekly Carboplatin Plus Paclitaxel in Triple Negative Breast Cancer

operable Triple Negative Breast Cancer (TNBC)

carboplatin
core needle biopsy
estrogen
immunohistochemistry
triple negative breast cancer
  • 54 views
  • 16 Jun, 2021
  • 1 location
Calorie Restriction With or Without Metformin in Triple Negative Breast Cancer

Glucose starvation and metformin have synergistic antitumor effects that are mediated through the concomitant inhibition of glycolysis and mitochondrial oxidative phosphorylation. The BREAKFAST trial will evaluate the antitumor activity of combining cyclic fasting-mimicking diet (FMD), which reproduces the in vitro effects of glucose starvation, plus/minus metformin with standard preperative anthracycline-taxane …

hysterectomy
gene amplification
mammogram
estrogen
metformin
  • 31 views
  • 25 Jan, 2021
  • 1 location