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Found 506 clinical trials
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MK-7684A With or Without Other Anticancer Therapies in Participants With Selected Solid Tumors (MK-7684A-005)

The purpose of this study is to determine the safety, tolerability, and preliminary efficacy of pembrolizumab/vibostolimab co-formulation (MK-7684A) with or without other anticancer therapies in participants with selected advanced solid tumors. The primary hypothesis is that pembrolizumab/vibostolimab co-formulation is superior to pembrolizumab alone in terms of objective response rate or …

adenocarcinoma of the gastroesophageal junction
measurable disease
carcinoma
adenosquamous carcinoma
breast cancer
  • 0 views
  • 08 Dec, 2021
  • 26 locations
None
Prospective Biobanking Study in Ovarian Breast and Head and Neck Cancer Patients Aiming at Better Understand the Link Between the Molecular Alterations of the Tumor Itself Its Microenvironment and Immune Response (SCANDARE)

SCANDARE is a prospective biobanking study on tumor (+/- nodes), plasma and blood samples at different time points in ovarian, triple negative breast and head and neck cancer patients. This study will allowed to identify new molecular and/or immunological biomarkers associated with clinical and biological features of the tumors. All …

cancer of the ovary
breast cancer
cancer
cancer chemotherapy
immunomodulator
  • 3 views
  • 28 Jan, 2021
  • 2 locations
None
A First-in-Human Study of CAN04 in Patients With Solid Malignant Tumors

This study will evaluate the safety, tolerability, and preliminary antitumor activity of CAN04 both as a monotherapy and in combination with standard of care treatment in subjects with solid cancer tumors. Following completion of the first part, the dose escalation cohorts, and determination of maximum tolerated dose or recommended phase …

platinum doublet
EGFR
measurable disease
chemotherapy regimen
cancer chemotherapy
  • 244 views
  • 20 Aug, 2021
  • 37 locations
None
A Study to Determine the Safety Tolerability Pharmacokinetics and Preliminary Efficacy of ABBV-927 With ABBV-368 Budigalimab (ABBV-181) and/or Chemotherapy in Participants With Locally Advanced or Metastatic Solid Tumors

A study evaluating the safety, pharmacokinetics (PK), pharmacodynamics, and preliminary efficacy of ABBV-927 with ABBV-368, Budigalimab (ABBV-181) and/or chemotherapy in participants with selected solid tumors. This study consists of 2 main parts, a dose-escalation phase and a dose-expansion phase. The dose-expansion phase can begin once the recommended phase 2 dose/maximum …

estrogen
primary cancer
advanced malignant solid tumor
growth factor
solid tumor
  • 52 views
  • 01 Aug, 2021
  • 38 locations
None
First Time in Human Study of AZD8701 With or Without Durvalumab in Participants With Advanced Solid Tumours

The purpose of this study is to Evaluate the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, Immunogenicity and Antitumor Activity of AZD8701 Alone and in Combination with Durvalumab (MEDI4736) in Adult Subjects with Select Advanced Solid Tumors

durvalumab
triple negative breast cancer
small lung
squamous cell carcinoma of head and neck
monoclonal antibodies
  • 52 views
  • 08 Dec, 2021
  • 15 locations
None
Study BT8009-100 in Subjects With Nectin-4 Expressing Advanced Solid Tumors Malignancies

This clinical trial is evaluating a drug called BT8009 alone and in combination with nivolumab in participants with advanced solid tumors associated with Nectin-4 expression or in participants with advanced solid tumor malignancies having renal insufficiency. The main goals of this study are to: Find the recommended dose of BT8009 …

line of therapy
nivolumab
triple negative breast cancer
diabetes
EGFR
  • 107 views
  • 08 Dec, 2021
  • 16 locations
None
OncoSNIPE - Study of Molecular Profiles Associated With the Development of Resistance in Solid Cancer Patients

pathologies concerned with resistance issues: triple negative breast cancer or Lum B or locally advanced or metastatic non -small-cell lung cancer or pancreatic cancer. In this project, in order to best cover

estrogen
primary cancer
cancer treatment
breast cancer
metastasis
  • 0 views
  • 18 Sep, 2021
  • 11 locations
None
A Phase I/Ib Study of NZV930 Alone and in Combination With PDR001 and /or NIR178 in Patients With Advanced Malignancies.

The purpose of this study is to assess the safety, tolerability, and preliminary anti-tumor activity of experimental medication NZV930 alone and when combined with PDR001 and/or NIR178, in patients with advanced cancers

  • 531 views
  • 30 Nov, 2021
  • 12 locations
None
GEN1046 Safety Trial in Patients With Malignant Solid Tumors

The purpose of the trial is to evaluate the safety of GEN1046 in patients with malignant solid tumors

squamous cell carcinoma of head and neck
measurable disease
stage iv non-small cell lung cancer
solid tumor
renal function
  • 79 views
  • 31 Oct, 2021
  • 41 locations
None
MGC018 With or Without MGA012 in Advanced Solid Tumors

The purpose of this study is to evaluate the safety and tolerability, pharmacokinetics (PK) pharmacodynamics and preliminary antitumor activity of MGC018 administered alone and in combination with MGA012 in patients with advanced solid tumors.

hormone therapy
systemic therapy
measurable disease
mgc018
chemotherapy regimen
  • 12 views
  • 29 Oct, 2021
  • 20 locations