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Found 477 clinical trials
Pharmacogenetic Testing of Patients With Unwanted Adverse Drug Reactions or Therapy Failure

Genetic makeup of a patient influences the efficacy and safety profile of a drug. This study is to summarize individual cases, where Pharmacogenetics (PGx) has been applied during pharmaceutical care. The primary objective is the compilation of case reports, where pharmacogenetic testing is applied to determine the hereditable component of …

pharmacogenomic testing
Accepts healthy volunteers
  • 17 Feb, 2022
  • 1 location
Observational Trial of Cardiotoxicity in Patients Undergoing Chemotherapy. (PROMETEY)

Advances in treatment have led to improved survival of patients with cancer, but have also increased morbidity and mortality due to cancer treatment side effects. Cardiotoxicity is one the most frequent side effect which may lead to premature morbidity and death among cancer survivors. The most concerning cardiovascular complications of …

heart transplantation
renal function
  • 15 Feb, 2022
  • 1 location
Integrating Pediatric Pharmacogenomic Testing Into the Canadian Health Care System

This project addresses the problem of adverse drug reactions in the three most frequently prescribed therapeutic classes of drugs in children: antibiotics, analgesics, and mental health medications. We will conduct pilot testing of a pharmacogenomic testing panel and study how the tests and generated test results are utilized and understood …

  • 26 Feb, 2022
  • 2 locations
Cancer Therapy Effects on the Heart (CTEH)

Anthracycline chemotherapies (e.g. doxorubicin, daunorubicin) are commonly given to treat pediatric cancer, and carry a risk of cardiotoxicity. Over the long term, children who receive these therapies have an increased risk of heart failure and early cardiovascular death. However, current strategies for identifying patients who are at risk prior to …

heart failure
cancer treatment
diagnostic tests
  • 26 Feb, 2022
  • 1 location
Monitoring of Metabolic Adverse Events of Second Generation Antipsychotics in a Naive Pediatric Population

Introduction: Second Generation Antipsychotics (SGAs) are widely used in the pediatric population. It is currently established that SGAs may induce undesirable metabolic adverse events (AEs) such as weight gain, metabolic changes in blood lipids or glucose with risk of potential cardiovascular morbidity and mortality. The Canadian Alliance for Monitoring Effectiveness …

hematology test
  • 24 Jan, 2021
  • 1 location
The Influence of CYP2C19 Polymorphisms on the Safety and Efficacy of Voriconazole

Voriconazole is a drug used to treat invasive fungal infections. The amount of voriconazole in a person's blood helps to determine how effectively it treats an infection, and how safe it is. Patients respond differently when receiving the same dose - some clearly benefit, other patients experience side effects, and …

  • 26 Jan, 2021
  • 1 location
Evaluation of a Rapid Microscopic Diagnostic System for Different Vaginitis Conditions

Evaluate the diagnostic performance of the Gyni™ device to detect different vaginitis conditions by comparison to microscopic diagnosis and related lab tests.

  • 24 Apr, 2022
  • 1 location
A Multicenter Observational Study on Safety of the Herbal Medicines at Inpatient Setting

Prospective observations on safety of the herbal medicines regarding liver and kidney injuries at inpatient setting of four sites in South Korea which are located at each quadrant of the country. In a previous study (PMID 28634823), six women presented liver injuries by herbs and similar findings were also reported. …

  • 21 Apr, 2022
4D-MRI for Precision Medicine

The purpose of this study is to develop new ways to make medical images of the lungs and liver of adults using a technique called four-dimensional magnetic resonance imaging (4D-MRI). This technique produces three-dimensional movies of the inside of the chest and abdomen while the patient is breathing. (The fourth …

  • 28 Jan, 2021
  • 1 location
Care of the Urothelial Cancer Patient and Prospective Procurement of Urothelial Cancer Tissue

Background Urothelial cancer is cancer of the bladder, ureter, and urethra. Researchers want to better understand what changes in a person s cells and genes cause this cancer to form. This may help them find new ways to treat it. Objective To perform DNA sequencing to help researchers learn the …

bladder tumor
urine test
bladder cancer
Accepts healthy volunteers
  • 13 May, 2022
  • 1 location