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Found 13 clinical trials
Featured trial
A Multicenter, Randomized, Double-blind, Placebo-controlled Study to Evaluate the Safety and Efficacy of Oral Treprostinil in Subjects with Pulmonary Hypertension (PH) in Heart Failure with Preserved Ejection Fraction (HFpEF)

A Multicenter, Randomized, Double-blind, Placebo-controlled Study to Evaluate the Safety and Efficacy of Oral Treprostinil in Subjects with Pulmonary Hypertension (PH) in Heart Failure with Preserved

  • 1004 views
  • 25 Mar, 2021
  • 1 location
None
Open Label Study of Treprostinil Palmitil Inhalation Powder (TPIP) In Pulmonary Arterial Hypertension (PAH)

The main purpose of this study is to evaluate the safety and tolerability of single doses of treprostinil palmitil inhalation powder (TPIP) in participants with pulmonary arterial hypertension

  • 0 views
  • 25 Nov, 2021
  • 2 locations
None
EXPEDITE: A Study of Remodulin Induction Followed by Orenitram Optimization to Treat Pulmonary Arterial Hypertension

This is a multicenter, open-label study to evaluate the dose of Orenitram (treprostinil) Extended Release Tablets achieved at 16 weeks after a short-term course of Remodulin (treprostinil

hypertrophy
hysterectomy
remodulin
connective tissue disease
left ventricular end-diastolic pressure
  • 97 views
  • 06 Aug, 2021
  • 10 locations
None
Trial to Evaluate Parenteral Treprostinil and Riociguat on Right Ventriculo-vascular Coupling and Morphology in Those With Advanced PAH

The purpose of this study is to determine if there is a greater effect to patients with advanced pulmonary arterial hypertension (PAH) by using a combination of two drugs, Treprostinil and

  • 0 views
  • 23 Jan, 2021
  • 1 location
None
Assessing Response to Inhaled Prostacyclin With Hyperpolarized Xe MRI

This study seeks to deploy several forms of 129Xe MRI contrast as well as emerging conventional proton MRI techniques for imaging lung structure and perfusion. Specifically, the 129Xe MRI scans will provide 3D images of ventilation and gas exchange, and spectroscopic indices will be evaluated too test gas exchange dynamics …

  • 0 views
  • 08 Jul, 2021
  • 1 location
None
A Phase 3 Adaptive Study to Evaluate the Safety and Efficacy of Inhaled Treprostinil in Participants With Pulmonary Hypertension (PH) Due to Chronic Obstructive Pulmonary Disease (COPD)

The primary objective of this study is to demonstrate the efficacy of inhaled treprostinil compared to placebo in improving exercise ability as measured by change from baseline in 6-Minute Walk

forced expiratory volume
left ventricular end-diastolic pressure
right heart catheterization
pulmonary disease
diuretics
  • 2043 views
  • 30 Nov, 2021
  • 70 locations
None
Inhaled Treprostinil in Sarcoidosis Patients With Pulmonary Hypertension

This study aims to evaluate the efficacy and safety of inhaled treprostinil in subjects with sarcoidosis-associated interstitial lung disease and pulmonary hypertension.

chest radiograph
sarcoidosis
ct scan
fibrosis
interstitial lung disease
  • 6 views
  • 22 Nov, 2021
  • 1 location
None
Iontophoresis of Treprostinil to Enhance Wound Healing in Diabetic Foot Skin Ulcers

Assess the effect of iontophoresis of treprostinil on wound closure over 12 weeks, in patients with DFU. In the present study the investigators aim at establishing the proof-of-concept of

skin ulcer
diabetes
type 2 diabetes mellitus
foot ulcer
  • 0 views
  • 26 Jan, 2021
  • 1 location
None
Study of Efficacy and Safety of Inhaled Treprostinil in Subjects With Idiopathic Pulmonary Fibrosis

Study RIN-PF-301 is designed to evaluate the safety and efficacy of inhaled treprostinil in subjects with idiopathic pulmonary fibrosis (IPF) over a 52-week period.

pirfenidone
pulmonary fibrosis
idiopathic pulmonary fibrosis
nintedanib
fibrosis
  • 5 views
  • 15 Oct, 2021
  • 23 locations
None
Effects of Treprostinil on Right Ventricular Structure and Function in Patients With Pulmonary Arterial Hypertension

In a group of patients with PAH treated with treprostinil, the current study aims to investigate the effect of treatment on RV structure and function; and correlate changes in RV structure and

walk tests
right heart catheterization
endothelin receptor antagonist
treprostinil
pulmonary arterial hypertension
  • 9 views
  • 23 Jan, 2021
  • 1 location