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Found 341 clinical trials
A Biomarker-Guided, Randomized, Double-Blind, Placebo-Controlled Efficacy and Safety Study of Liafensine in Patients With Treatment Resistant Depression (ENLIGHTEN)

This study will be conducted as a randomized, double-blind, placebo-controlled, multi-center Phase 2b study. Approximately 180 subjects with treatment resistant depression who meet all

  • 0 views
  • 21 Jul, 2022
  • 2 locations
Efficacy and Safety of MK-1942 When Added to Stable Antidepressant Therapy in Participants With Treatment-Resistant Depression (TRD) (MK-1942-006)

The main purpose of this study is to assess the efficacy and safety of daily and intermittent dosing of MK-1942 compared to placebo among participants with Treatment-Resistant Depression (TRD

  • 61 views
  • 08 Aug, 2022
  • 24 locations
A Randomized, Placebo-Controlled, Double-Blind Study to Assess Safety and Efficacy of PCN-101 in TRD

This is a double-blind, randomized, placebo-controlled, multicenter study comprised of 3 phases:screening (up to 2 weeks [Day -15 to Day -2]), In-Clinic Treatment (Day -1 to Day 2; including double-blind treatment [Day 1]), and post-treatment follow-up (7 and 14 days after infusion on Days 8 and 15, respectively). A total …

  • 0 views
  • 10 Aug, 2022
  • 10 locations
Transcranial Magnetic Stimulation of the Default Mode Network to Improve Sleep

Insomnia is generally believed to be caused by excessive arousal of the brain and body. Rather than transitioning normally and quickly from wakefulness to sleep, individuals with insomnia tend to enter into a self-perpetuating cycle of self-referential thought and arousal. Brain imaging research has shown that these same internally focused …

primary insomnia
polysomnography
  • 11 views
  • 22 Aug, 2021
  • 1 location
Collaborative Stepped-Care and Productive Ageing Program for Older People With Depressive Symptoms

The Jockey Club Holistic Support Project for Elderly Mental Wellness (JC JoyAge) has developed and implemented a collaborative stepped care model for older persons at-risk of or with depression in four districts in Hong Kong since 2015 (Clinical Trials Identifier: NCT03593889). Results from JC JoyAge show that the collaborative stepped-care …

behavior therapy
depressed mood
depressive symptoms
psychotherapy
  • 0 views
  • 24 May, 2021
  • 4 locations
Esketamine and Perioperative Depressive Symptoms

could resolve this clinical problem during limited perioperative period. The remarkable effects of ketamine on treatment resistant depression have been verified by several clinical trials and the

depressive symptoms
treatment resistant depression
ketamine
depressed mood
anxiety
  • 0 views
  • 14 Mar, 2022
  • 1 location
Reaching Out to Distressed Medical Residents Fellows and Faculty

The purpose of this study is to study whether distressed medical residents, fellows, and faculty health professionals benefit from completing online an anonymous and interactive screening of stress, depression, substance use, and suicidal thoughts. The screening and ability to interact online with a clinician anonymously are hypothesized to increase willingness …

depression
substance use
suicidal
depressed mood
suicide
  • 33 views
  • 25 Jan, 2021
  • 1 location
Sleep To Reduce Incident Depression Effectively (STRIDE)

This project will assess the effectiveness of a stepped-care model (i.e. digital Cognitive Behavioral Therapy for Insomnia (dCBT-I) followed by face-to-face CBT-I) in improving severity of insomnia and sleep outcomes in an insomnia cohort. This project will also investigate the effectiveness of this stepped-care model in prevention of major depressive …

depressive disorder
insomnia
scid
depressed mood
cognitive behavior therapy for insomnia
  • 537 views
  • 14 Mar, 2022
  • 1 location
PDA for Antidepressant Use in Pregnancy

Depression in pregnancy is common, affecting up to 10% of women and represents serious risk to mother and infant. Unfortunately, antidepressant medication, a first-line treatment for depression in pregnancy, also comes with risks, making this a complex decision. Clinical care appears to be insufficient for ensuring that women make decisions …

major depressive disorder
antidepressants
depressive disorder
remission
norepinephrine
  • 117 views
  • 21 Mar, 2022
  • 1 location
Enhancing the Clinical Effectiveness of Depression Screening Using Patient-targeted Feedback in General Practices

The multi-center GET.FEEDBACK.GP randomized controlled trial is designed based on patients' needs and preferences. In order to evaluate the effect of feedback in the broader setting of primary care, a total of 1076 primary care patients with elevated levels of depression (PHQ-9 score ≥ 10) will be randomized into three …

depressed mood
depression screening
  • 0 views
  • 23 May, 2022
  • 1 location