Found 215 clinical trials
Rapid Acting Transcranial Magnetic Stimulation
This study evaluates an accelerated schedule of theta-burst stimulation using a transcranial magnetic stimulation device for treatment-resistant depression. In a double-blind, randomized, sham
- 0 views
- 13 May, 2022
- 1 location
Neural and Antidepressant Effects of Propofol
This study will compare the antidepressant effects of propofol at two different doses while measuring potential treatment-related biomarkers.
- 192 views
- 04 Feb, 2022
- 1 location
Personalized Therapeutic Neuromodulation for Anhedonic Depression
resistant depression (TRD) or BD. aiTBS is a novel application of repetitive transcranial magnetic stimulation (TMS), that induces remission in 90% of individuals with severe, treatment resistant MDD in 1-5
- 0 views
- 19 Jun, 2022
- 1 location
Virtual Neuro-Navigation System for Personalized Community Based TMS
Phase I study of a virtual neuro-navigation package with built-in support for identifying specific "surface-based" targets to optimze TMS treatment.
- 0 views
- 06 May, 2022
- 1 location
A Phase 2a, Randomized, Placebo-Controlled Clinical Study to Evaluate the Efficacy and Safety of MK-1942 Added to Stable Antidepressant Therapy in Participants With Treatment-Resistant Depression
The main purpose of this study is to assess the efficacy and safety of daily and intermittent dosing of MK-1942 compared to placebo among participants with Treatment-Resistant Depression (TRD
- 76 views
- 21 Oct, 2022
- 31 locations
Efficacy and Safety of Psilocybin in Treatment-Resistant Major Depression (EPIsoDE)
The study aims to investigate the safety and efficacy of oral psilocybin administered under supportive conditions in treatment-resistant major depression (TRD). The study is a bi-centric, prospective, randomized, active placebo-controlled study investigating the effects of 25 mg and 5 mg (p.o.) psilocybin versus placebo (100 mg nicotinamide) in a psychotherapeutic …
- 1 views
- 10 Apr, 2023
- 1 location
Enhanced Spatial Targeting in ECT Utilizing FEAST
The purpose of this research study is to find an alternative version of ECT that reduces the negative side effects (mainly memory loss) while still providing patients with relief from depressive symptoms. Previous forms of ECT may use Bilateral (electrodes on both sides of the head) or Right Unilateral (electrodes …
- 23 views
- 09 Apr, 2023
- 1 location
Early Identification of TRD and Construction and Clinical Validation of NTBS Precision Technology
The goal of this clinical trial is to learn about the characteristics, identify early and intervene effectively in time in Treatment-Resistant Depression. The main questions are: • TRD is
- 0 views
- 11 Apr, 2023
- 1 location
Repeated Ketamine Infusions for Treatment-Resistant Bipolar Disorder: A Randomized, Double-blind, Midazolam-controlled, Phase II Clinical Trial (KET-BD)
Growing evidence has supported rapid and robust antidepressant effects with subanesthetic doses of intravenous (IV) ketamine for treatment resistant depression (TRD). However, no completed or
- 0 views
- 19 Oct, 2022
- 1 location
Esketamine and Perioperative Depressive Symptoms
could resolve this clinical problem during limited perioperative period. The remarkable effects of ketamine on treatment resistant depression have been verified by several clinical trials and the
- 38 views
- 08 Apr, 2023
- 1 location