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Found 260 clinical trials
Psilocybin in Depression Resistant to Standard Treatments

A single centre clinical trial to evaluate the feasibility, safety and efficacy of psilocybin, given under supportive conditions, in a randomised, blinded design in adult participants with treatment resistant major depressive disorder. The primary objective is to evaluate feasibility by measuring recruitment rates, dropout rates and by estimating the variance …

  • 29 views
  • 30 Jul, 2021
  • 1 location
Transcranial Magnetic Stimulation of the Default Mode Network to Improve Sleep

Insomnia is generally believed to be caused by excessive arousal of the brain and body. Rather than transitioning normally and quickly from wakefulness to sleep, individuals with insomnia tend to enter into a self-perpetuating cycle of self-referential thought and arousal. Brain imaging research has shown that these same internally focused …

polysomnography
primary insomnia
  • 21 views
  • 22 Aug, 2021
  • 1 location
Esketamine and Perioperative Depressive Symptoms

could resolve this clinical problem during limited perioperative period. The remarkable effects of ketamine on treatment resistant depression have been verified by several clinical trials and the

depressive symptoms
depressed mood
anxiety
treatment resistant depression
ketamine
  • 19 views
  • 14 Mar, 2022
  • 1 location
Enhancing the Clinical Effectiveness of Depression Screening Using Patient-targeted Feedback in General Practices

The multi-center GET.FEEDBACK.GP randomized controlled trial is designed based on patients' needs and preferences. In order to evaluate the effect of feedback in the broader setting of primary care, a total of 1076 primary care patients with elevated levels of depression (PHQ-9 score ≥ 10) will be randomized into three …

depression screening
depressed mood
  • 6 views
  • 23 May, 2022
  • 1 location
PATH 2 Purpose: Primary Care and Community-Based Prevention of Mental Disorders in Adolescents (P2P)

PATH (Promoting AdolescenT Health) 2 Purpose is a two-arm comparative effectiveness research trial to that will evaluate the ability of the interventions, Competent Adulthood Transition with Cognitive-behavioral & Interpersonal Training (CATCH-IT) and Teens Achieving Mastery over Stress (TEAMS), to intervene early to prevent depressive illness and potentially other common mental …

depressive disorder
depressive symptoms
depressed mood
psychiatric disorder
behavior therapy
  • 47 views
  • 25 Jul, 2022
  • 1 location
Reaching Out to Distressed Medical Residents Fellows and Faculty

The purpose of this study is to study whether distressed medical residents, fellows, and faculty health professionals benefit from completing online an anonymous and interactive screening of stress, depression, substance use, and suicidal thoughts. The screening and ability to interact online with a clinician anonymously are hypothesized to increase willingness …

depressed mood
suicidal
substance use
suicide
depression
  • 33 views
  • 25 Jan, 2021
  • 1 location
PDA for Antidepressant Use in Pregnancy

Depression in pregnancy is common, affecting up to 10% of women and represents serious risk to mother and infant. Unfortunately, antidepressant medication, a first-line treatment for depression in pregnancy, also comes with risks, making this a complex decision. Clinical care appears to be insufficient for ensuring that women make decisions …

depressive disorder
norepinephrine
depressed mood
major depressive disorder
antidepressants
  • 122 views
  • 21 Mar, 2022
  • 1 location
Sleep To Reduce Incident Depression Effectively (STRIDE)

This project will assess the effectiveness of a stepped-care model (i.e. digital Cognitive Behavioral Therapy for Insomnia (dCBT-I) followed by face-to-face CBT-I) in improving severity of insomnia and sleep outcomes in an insomnia cohort. This project will also investigate the effectiveness of this stepped-care model in prevention of major depressive …

behavioral therapy
depressive disorder
depressed mood
behavior modification
depressive symptoms
  • 543 views
  • 14 Mar, 2022
  • 1 location
Music Interventions for Dementia and Depression in Elderly Care (MIDDEL)

This study evaluates the effectiveness of two music-based approaches - group music therapy and recreational choir singing - for reducing depression symptoms in people living with dementia. It also examines mechanisms and heterogeneity of treatment effects.

depressive symptoms
mental state examination
depressed mood
dementia
anxiety
  • 18 views
  • 22 Mar, 2022
  • 5 locations
3D Team Care for Cognitively Vulnerable Older Adults

This study addresses how to achieve better outcomes for cognitively vulnerable community-dwelling older adults and their families. Cognitive vulnerability means living with dementia, depression, and/or a recent episode of delirium (the 3Ds). The investigators will test the effectiveness of a team care model focused on the 3Ds (Home Based Care …

depressed mood
dementia
cognitive impairment
depression
  • 30 views
  • 15 Mar, 2022
  • 1 location