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Found 345 clinical trials
Neurofeedback for Treatment Resistant Depression

The purpose of this study is to determine the clinical efficacy of real-time functional magnetic resonance imaging neurofeedback (rtfMRI-nf) training to increase the amygdala's response to positive autobiographical memories in patients with depression who are considered treatment-resistant

antidepressants
depressed
anhedonia
functional magnetic resonance imaging
  • 149 views
  • 24 Mar, 2022
  • 1 location
Tianeptine for Treatment Resistant Depression

The study will be conducted in parallel at two sites: the Clinic for Aging, Anxiety and Mood Disorders (CAAM) at Columbia University/New York State Psychiatric Institute (CU/NYSPI) and the Mood and Anxiety Disorders Program at the Icahn School of Medicine at Mount Sinai (MSSM). The following procedures will be approved …

mirtazapine
depressive disorder
antidepressants
bupropion
snri
  • 37 views
  • 21 Apr, 2022
Antidepressant Discontinuation in Treatment Resistant Depression

treating treatment-resistant depression.

depressive disorder
prozac
depressive symptoms
antidepressants
  • 93 views
  • 04 Jun, 2022
  • 1 location
Psilocybin Versus Ketamine in Treatment-Resistant Depression (PSIKET_001)

The main goal is to compare the antidepressant effects of psilocybin and ketamine in patients with TRD versus the antidepressant inactive substance midazolam. The primary endpoint will be the antidepressant effect on the Montgomery- Asberg Depression Rating Scale (MADRS) 24 hours after treatment, the key secondary endpoints being the duration …

  • 0 views
  • 03 Jun, 2022
  • 1 location
PCS in Severe Treatment Resistant Depression

This research study is designed to test if electrical stimulation of the surface of the brain in the frontal region will help treat depressive symptoms. Participants receive intermittent electrical stimulation to the brain, which involves surgically placing electric leads in between the tough fibrous membrane covering the surface of the …

  • 0 views
  • 05 Jun, 2022
  • 1 location
Minocycline as Adjunctive Treatment for Treatment Resistant Depression (MINDEP2)

Major depressive disorder (MDD) is a leading cause of disability worldwide. Up to 50% of patients experience treatment resistant depression (TRD), which accounts for a vast majority of disease

adjunctive treatment
depressive episode
antibiotic
antidepressants
venlafaxine
  • 108 views
  • 25 May, 2022
  • 1 location
Phase 2 Study of NV-5138 in Adults With Treatment Resistant Depression

This study will evaluate the efficacy and safety of NV-5138 in adults with TRD

  • 0 views
  • 07 Apr, 2022
Efficacy Study of Deep Brain Stimulation in Patients With Treatment Resistant Major Depression (FORESEE III)

The primary objective of this multicenter, randomized, sham-controlled, double blind (patient and observer blinded) clinical trial is to assess the antidepressant effect of Deep Brain Stimulation (DBS) in patients with treatment resistant major depression using the Boston Scientific implantable Vercise GEVIA DBS system compared to sham.

  • 55 views
  • 14 Feb, 2022
  • 1 location
Neural and Antidepressant Effects of Propofol

This study will compare the antidepressant effects of propofol at two different doses while measuring potential treatment-related biomarkers.

bipolar disorder
depressive disorder
depressive episode
antidepressants
hdrs
  • 192 views
  • 04 Feb, 2022
  • 1 location
Slow Wave Induction by Propofol to Eliminate Depression (SWIPED)

Our overall hypothesis is that sleep slow-wave potentiation by propofol is a therapeutic pathway for enhancing slow wave sleep and alleviating treatment-resistant depression (TRD).

  • 0 views
  • 23 Mar, 2022
  • 1 location