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Found 281 clinical trials
LIFE - Lung Cancer Immunotherapy Frailty Effect

The LIFE study (Lung cancer, Immunotherapy, Frailty, Effect) is investigating the unselected 'real life' non-small cell lung cancer (NSCLC) population treated with immune checkpoint inhibition.

  • 0 views
  • 27 Jan, 2021
  • 1 location
Qualitative Understanding of Experiences With the SIMPLIFY Trial

This qualitative longitudinal study is designed to elicit and thematically analyze the perspectives of SIMPLIFY subjects about treatment withdrawal research and treatment burden in the context of triple combination CFTR (Cystic Fibrosis Transmembrane Conductance Regulator) modulator therapy (TCT). Cohorts will be determined based on sub-groups of the assigned treatment arms …

  • 0 views
  • 13 Feb, 2021
  • 2 locations
AIMS Cancer Outcomes Study

The overall aim is to describe disease-free survival (DFS) in early stage cancer patients and three-year overall survival (OS) outcomes in advanced stage cancer patients receiving Advanced Integrative Oncology (AIO) treatment in a prospective consecutive case series outcomes study. We will collect data and study outcomes for patients with cancer …

primary cancer
cancer
  • 0 views
  • 24 Jan, 2021
  • 1 location
Chemotherapy Host Response and Molecular Dynamics in Periampullary Cancer

The CHAMP (Chemotherapy, Host response And Molecular dynamics in Periampullary cancer) study is a prospective, single-arm observational study that started Sept 1 2018. Patients diagnosed with pancreatic or other periampullary adenocarcinoma undergoing adjuvant och palliative chemotherapy are invited to participate. The study will examine the tumors' molecular dynamics and how …

immunostimulant
gemcitabine
cancer chemotherapy
adenocarcinoma
periampullary adenocarcinoma
  • 4 views
  • 18 Mar, 2021
  • 3 locations
ATHN 8: Previously Untreated Patients (PUPs) Matter Study

This is a multi-center cohort study of approximately 250 previously untreated patients (PUPs) with congenital moderate to severe hemophilia A or B in a network of up to 50 US Hemophilia Treatment Centers (HTCs). Participants will be followed as they receive their first 50 exposure days (ED) to clotting factor …

severe haemophilia a
bleeding tendency
coagulation factor
Factor VIII
hemophilia
  • 1 views
  • 12 Sep, 2021
  • 26 locations
Excretion of Acetylamantadine (AA) by Lung Cancer Patients During a Chemotherapy Regimen

This study is designed to determine if changes in acetyl amantadine (AA) metabolism with systemic chemotherapy - reflective of SSAT1 activity - are predictive of response to systemic therapy in patients with lung cancer. Ten patients with adenocarcinoma and 10 with small-cell cancer who are at American Joint Committee on …

cancer
lung carcinoma
cancer chemotherapy
adenocarcinoma
lung cancer
  • 2 views
  • 25 Mar, 2021
  • 2 locations
Short-course Radiotherapy (5 6Gy/7Gy/8Gy) Followed by Neo-adjuvant Chemotherapy for Locally Advanced Rectal Cancer

Preoperative radiotherapy followed by total mesorectal excision (TME) has been recommended as the preferred treatment method for locally advanced rectal cancer. Similar rates of local control, survival and toxicity were observed in preoperative long-course radiotherapy (LCRT) (45-50.4 Gy in 25-28 fractions) and short-course radiotherapy (SCRT) of 25 Gy in five …

renal function
total mesorectal excision
adenocarcinoma
  • 13 views
  • 25 Jan, 2021
  • 1 location
Assessing the Impact of Control-IQ Technology

This is a single-centre, mixed-methods, prospective study in pediatric patients with T1D initiating Control-IQ technology on the Tandem t-slim X2 insulin pump. Primary Objective: To determine pediatric T1D patients' and their parents' perceptions of the impact of Control-IQ on their psychosocial functioning and quality of life.

  • 0 views
  • 14 Apr, 2021
  • 1 location
Immune Checkpoint Inhibitors Nephrotoxicity

In recent years, immunotherapy has been postulated as one of the most effective strategy in the fight against cancer. The greatest success in this field has been achieved through the inhibition of molecules involved in the brake of the adaptive immune response. The compounds capable of blocking the action of …

  • 0 views
  • 04 Jun, 2021
  • 2 locations
Perceptions of LARC Among AYA With Chronic Illness

The investigators aim to perform a qualitative study exploring attitudes and perceived barriers to Long Acting Reversible Contraception (LARC), both implants and IUDs, among adolescent and young adults (AYA) with chronic illness at CHLA. While the literature examining barriers to LARC uptake is growing, its focus has been on older …

  • 0 views
  • 19 Aug, 2021
  • 1 location