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Found 274 clinical trials
Dolutegravir Plus Lamivudine Simplified Therapy

Dolutegravir (DTG) is one type of integrase inhibitor, lamivudine (3TC) is one type of reverse transcriptase inhibitor, both of which are HIV medicine prevents HIV from self-multiplying, reduces the viral load. The data of the existing randomized controlled clinical studies show that the simplified two-drug DTG-based regimen is similar to …

lamivudine
osteoporosis
reverse transcriptase inhibitor
integrase inhibitors
hiv-1 rna measurement
  • 2 views
  • 23 Jul, 2021
  • 1 location
Drug Sensitivity and Mutation Profiling

This study is a prospective, non-randomized observational study. Freshly isolated tumor cells will be tested for chemosensitivity to the standard of care drugs as single agents and in combinations using state-of-the-art viability assay designed for ex-vivo high-throughput drug sensitivity testing (DST). In addition, the genetic profile of the tumor will …

tumor cells
  • 0 views
  • 19 Jul, 2021
  • 1 location
ATHN 7: Hemophilia Natural History Study

This is a real-world study of the safety of the treatments used for people with hemophilia. The study will follow people with hemophilia A or B from across the country for about 4 years as they receive treatment. The hemophilia treatment center (HTC) physician and participant will decide on the …

  • 4 views
  • 25 Jan, 2021
  • 37 locations
Assessment of Optune Therapy for Patients With Newly Diagnosed Glioblastoma Using Advanced MRI

The purpose of this prospective, nonrandomized controlled phase IV study is to compare standard and advanced MRI for their ability to predict response to Optune therapy.

tumor treating fields therapy
MRI
cancer
  • 553 views
  • 26 Apr, 2021
  • 1 location
AIMS Cancer Outcomes Study

The overall aim is to describe disease-free survival (DFS) in early stage cancer patients and three-year overall survival (OS) outcomes in advanced stage cancer patients receiving Advanced Integrative Oncology (AIO) treatment in a prospective consecutive case series outcomes study. We will collect data and study outcomes for patients with cancer …

cancer
primary cancer
  • 0 views
  • 24 Jan, 2021
  • 1 location
Qualitative Understanding of Experiences With the SIMPLIFY Trial

This qualitative longitudinal study is designed to elicit and thematically analyze the perspectives of SIMPLIFY subjects about treatment withdrawal research and treatment burden in the context of triple combination CFTR (Cystic Fibrosis Transmembrane Conductance Regulator) modulator therapy (TCT). Cohorts will be determined based on sub-groups of the assigned treatment arms …

  • 0 views
  • 13 Feb, 2021
  • 2 locations
LIFE - Lung Cancer Immunotherapy Frailty Effect

The LIFE study (Lung cancer, Immunotherapy, Frailty, Effect) is investigating the unselected 'real life' non-small cell lung cancer (NSCLC) population treated with immune checkpoint inhibition.

  • 0 views
  • 27 Jan, 2021
  • 1 location
Chemotherapy Host Response and Molecular Dynamics in Periampullary Cancer

The CHAMP (Chemotherapy, Host response And Molecular dynamics in Periampullary cancer) study is a prospective, single-arm observational study that started Sept 1 2018. Patients diagnosed with pancreatic or other periampullary adenocarcinoma undergoing adjuvant och palliative chemotherapy are invited to participate. The study will examine the tumors' molecular dynamics and how …

immunostimulant
periampullary adenocarcinoma
adenocarcinoma
cancer chemotherapy
gemcitabine
  • 4 views
  • 18 Mar, 2021
  • 3 locations
Excretion of Acetylamantadine (AA) by Lung Cancer Patients During a Chemotherapy Regimen

This study is designed to determine if changes in acetyl amantadine (AA) metabolism with systemic chemotherapy - reflective of SSAT1 activity - are predictive of response to systemic therapy in patients with lung cancer. Ten patients with adenocarcinoma and 10 with small-cell cancer who are at American Joint Committee on …

lung carcinoma
cancer
cancer chemotherapy
adenocarcinoma
lung cancer
  • 2 views
  • 25 Mar, 2021
  • 2 locations
ATHN 8: PUPs Matter Study

This is a multi-center cohort study of approximately 250 previously untreated patients (PUPs) with congenital moderate to severe hemophilia A or B in a network of up to 50 US Hemophilia Treatment Centers (HTCs). Participants will be followed as they receive their first 50 exposure days (ED) to clotting factor …

hemophilia
coagulation factor
severe haemophilia a
christmas disease
Factor VIII
  • 1 views
  • 25 Jan, 2021
  • 26 locations