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Found 433 clinical trials
Predicting Postoperative Delirium Using EEG Genetics and Neurobiomarkers of Cerebral Injury

The overall goal of this research project is to elucidate underlying pathophysiological mechanisms of postoperative delirium (POD) and to specifically validate perioperative predictive factors that will help in indentifying patients at higher risk of developing POD. The main objective is to evaluate whether intraoperative frontal alpha power in unprocessed electroencephalogram …

electroencephalogram
heart surgery
intraoperative eeg
anesthesia
cerebral injury
  • 0 views
  • 25 Jan, 2021
  • 1 location
Decreasing Risk of Psychosis by Sulforaphane (DROPS Trial)

This is a randomized, double-blind, placebo-controlled, multi-centre trial. A total of 300 CHR subjects will be identified in the course of face-to-face interviews using the Structured Interview for Prodromal Syndromes. All participants will be randomly allocated to SFN group (n = 150) or placebo group (n = 150). The study …

  • 1 views
  • 25 Jan, 2021
  • 11 locations
Transcranial Magnetic Stimulation (TMS) in Schizophrenia

Until recently stimulation of nervous tissue deeper than approximately 2 cm from the scalp (will hence be called non-deep TMS) was not possible (3).A new coil ("H"-coil invented in Weizmann Institute of Science, Neurobiology Department, Rehovot, Israel ) capable of stimulating more than twice this depth (Up to 5 cm)was …

hallucinations
suicide
psychotropic drugs
auditory hallucinations
  • 8 views
  • 07 Nov, 2020
  • 1 location
Improving Tumor Treating Fields Treatment for Brain Cancer Patients With Skullremodeling Surgery (Neurosurgery)

The aim of this trial is to test a new potential treatment, skullremodeling surgery (SR-surgery) combined with tumor treating fields (TTFields), for patients with first recurrence of malignant brain tumor (first recurrence of glioblastoma). Glioblastoma is one of the most malignant cancers. TTFields is a new treatment for brain cancer …

  • 0 views
  • 26 Jan, 2021
  • 1 location
Is Sensory Stimulation Effective in Reducing Time Spent in a Coma or Vegetative State

A randomised control trial of patients who have a severe brain injury to determine if patients who receive a standardised sensory stimulation program emerge earlier from a vegetative state. The experimental group would receive, in addition to their normal occuaptional therapy, sensory stimulation which would involve the daily application of …

coma
  • 36 views
  • 07 Nov, 2020
  • 1 location
Transcranial Ultrasonography for the Management of Patients With Mild TBI

The investigators hypothesize that patients with mild TBI and normal TCD can be safely discharged home immediately after the ED. The targeted population is the category of patients eligible for

ct scan
headache
anticoagulant
nausea
vomiting
  • 4 views
  • 15 Apr, 2021
  • 22 locations
Brain Oxygen Optimization in Severe TBI Phase 3

BOOST3 is a randomized clinical trial to determine the comparative effectiveness of two strategies for monitoring and treating patients with traumatic brain injury (TBI) in the intensive care

traumatic brain injury
ct scan
coma
  • 18 views
  • 01 Apr, 2021
  • 35 locations
PROphylaxis for Venous ThromboEmbolism in Severe Traumatic Brain Injury (PROTEST)

This is a pilot study, phase III, multi-centre, double blind, randomized controlled trial of patients with traumatic brain injury (TBI).

severe traumatic brain injury
traumatic brain injury
subarachnoid hemorrhage
  • 50 views
  • 24 Jun, 2021
  • 10 locations
Clinical Randomisation of an Anti-fibrinolytic in Symptomatic Mild Head Injury in Older Adults

Tranexamic acid (TXA) reduces head injury deaths. The CRASH-4 trial aims to assess the effects of early intramuscular TXA on intracranial haemorrhage, disability, death, and dementia in older adults with symptomatic mild head injury

head injury
  • 0 views
  • 23 May, 2021
  • 2 locations
Dexamethasone for the Treatment of Vasogenic Pericontusional Edema.

The DEXCON-TBI trial is a multicenter, pragmatic, randomized, triple-blind, placebo controlled trial to quantify the effects of the administration of dexamethasone on the prognosis of TBI

  • 0 views
  • 27 Jan, 2021
  • 1 location