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Found 432 clinical trials
A Prospective Controlled Treatment Trial for Post-Traumatic Headaches

Post-traumatic headaches (PTH) are the most common complaint after traumatic brain injury, possibly generated by a number of stressors to the trigeminovascular and cervical plexus networks

  • 15 Jun, 2021
  • 2 locations
Randomised Prospective Comparison of the NMA Allograft and the Traditional Allograft in Acute Myeloid Leukaemia

The allograft of marrow in its technique of reference (myélo-ablative (MA) condition by cyclophosphamide and total body irradiation (TBI) with strong amounts) therapeutic is recognized

secondary acute myeloid leukemia
total body irradiation
  • 07 Nov, 2020
  • 1 location
Real-Time Decision Support for Improving Intraoperative Cerebral Perfusion Pressure

Brain Trauma Foundation recommends that cerebral perfusion pressure (CPP) be maintained greater than 60 mmHg in high-risk settings to minimize risk of cerebral ischemia. Though several lines of

  • 03 Apr, 2021
  • 1 location
Detection and Amelioration of Gamma Oscillation Abnormalities in Blast-Related Brain Injury

Combat Veterans of post-9/11 conflicts have experienced serious cognitive and emotional problems resulting from exposure to blasts. Recent work suggests that a critical factor influencing the consequences of blast exposure is distance from the blast, rather than the presence or absence of concussion symptoms. Exposure to blasts from a distance …

  • 02 Apr, 2021
  • 1 location
An Efficacy and Safety Study of MYOBLOC in the Treatment of Adult Lower Limb Spasticity Followed by an Open-Label Multiple-Treatment Safety Study

Multicenter, randomized, double-blind, placebo-controlled study of the safety and efficacy of single-dose MYOBLOC over a 1-year duration in adult subjects with lower limb spasticity, followed by an open-label extension safety study of multiple doses.

traumatic brain injury
  • 27 Jan, 2021
  • 4 locations
Haploidentical Bone Marrow Transplant With Post-Transplant Cyclophosphamide for Patients With Severe Aplastic Anemia

Severe aplastic anemia is a rare and serious form of bone marrow failure related to an immune-mediated mechanism that results in severe pancytopenia and high risk for infections and bleeding. Patients with matched sibling donors for transplantation have a 80-90% chance of survival; however, a response rate with just immunosuppression …

anemia severe
bone marrow transplant
total body irradiation
reticulocyte count
  • 05 Mar, 2021
  • 2 locations
Allograft for Sickle Cell Disease and Thalassemia

The design of the study incorporates the following features: This is a phase II study to determine the safety and therapeutic potential of a new transplant approach (disease-free survival, graft versus myeloma effect) and to evaluate its toxicity profile (immediate toxicity, graft-versus-host disease, graft rejection, mortality) in a patient population …

  • 18 Feb, 2021
  • 1 location
Pilot Study of Reduced-Intensity Hematopoietic Stem Cell Transplant of DOCK8 Deficiency

Background -DOCK8 deficiency is a genetic disorder that affects the immune system and can lead to severe recurrent infections and possible death from infections or certain types of cancers, including blood cancers. A stem cell transplant is a life-saving treatment for this condition. In this study we are evaluating the …

  • 20 Jun, 2021
  • 1 location
Curcumin/Turmeric as a Treatment for Patients With Subdural Hematomas Recurrence

Our long-term objective is to evaluate the efficacy of curcumin (CC) in preventing a recurrence of chronic subdural hematoma (cSDH) following surgical evacuation. Recurrence is defined as an increase in total hematoma volume on the operated side compared to a post-operative day one CT scan with persistent or recurrent neurological …

  • 22 Jan, 2021
  • 1 location
Predicting Postoperative Delirium Using EEG Genetics and Neurobiomarkers of Cerebral Injury

The overall goal of this research project is to elucidate underlying pathophysiological mechanisms of postoperative delirium (POD) and to specifically validate perioperative predictive factors that will help in indentifying patients at higher risk of developing POD. The main objective is to evaluate whether intraoperative frontal alpha power in unprocessed electroencephalogram …

cardiopulmonary bypass
heart surgery
intraoperative eeg
  • 25 Jan, 2021
  • 1 location