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Found 433 clinical trials
Haploidentical Transplant for People With Chronic Granulomatous Disease (CGD) Using Alemtuzumab Busulfan and TBI With Post-Transplant Cyclophosphamide

Background CGD causes infections and inflammation. The only cure currently is a bone marrow transplant. Most often a perfectly matched bone marrow donor is used. Researchers want to see if they can lower the risks of using a mismatched donor. Objectives To see if it is safe to use a …

blood test
alemtuzumab
cyclophosphamide
bone marrow transplant
sirolimus
  • 1 views
  • 24 Jun, 2021
  • 1 location
  • 3060 views
  • 04 Jun, 2021
  • 84 locations
Efficacy of R-CHOP vs R-CHOP/R-DHAP in Untreated MCL

followed by total body irradiation [TBI]/high dose cytarabine [ARA-C]/melphalan-peripheral blood stem cell transplantation (TAM-PBSCT) can improve the time to treatment failure compared to CHOP

doxorubicin
dexamethasone
high dose chemotherapy
cell transplantation
vincristine
  • 134 views
  • 07 Nov, 2020
  • 2 locations
Brain Network Disruptions Related to Traumatic Coma

To provide a fine-grained description of the brain network dysfunctions induced by severe traumatic brain injury (TBI) or anoxic encephalopathy, that are responsible for the acute state of

  • 32 views
  • 25 Jan, 2021
  • 1 location
Problem Solving for Caregivers of Persons With Brain Injury

Family caregivers of persons with traumatic brain injury (TBI) have long-term demands that tax their coping abilities and adversely affect their health and well-being. This project will

traumatic brain injury
  • 77 views
  • 07 Nov, 2020
  • 1 location
Identifying Correlates of Brain Microglial Activation in Neuropsychiatric Syndromes: A Dimensional Approach

, chronic pain syndrome, dementia, traumatic brain injury, or substance abuse. The research will also explore whether there is more inflammation in patients with more neuropsychiatric symptoms. Inflammation

  • 6 views
  • 22 Jan, 2021
  • 1 location
Multidisciplinary Translational Approach to Investigate Mechanisms Predictors & Prevention of Persistent PTH

brain injury, and identify methods of preventing post-traumatic headache persistence. The objective of the clinical trial component of the Focused Program is to determine whether intervention

  • 0 views
  • 18 Feb, 2021
  • 3 locations
Imaging of Neuro-Inflammation and the Risk for Post-Traumatic Epilepsy

This study plans to evaluate the time course of inflammation in the brain after a moderate to severe traumatic brain injury using positron emission tomography (PET) brain imaging. Patients will

  • 1 views
  • 19 Jun, 2021
  • 1 location
Respiratory Side Effects of Busulfan High Dose Chemotherapy in a Pediatric Population

Recently, several conditioning regimens did not include total body irradiation (TBI) anymore, especially in the case of young children due to cognitive sequelae and late effects on growth

  • 6 views
  • 07 Nov, 2020
  • 1 location
Rehabilitation and Longitudinal Follow-up of Cognition in Adult Lower Grade Gliomas

standard of care to treat cognitive deficits in brain tumor patients, standard cognitive rehabilitative treatments have been developed for those with traumatic brain injury and stroke. However, the

brain tumor
stroke
seizure
MRI Scan
karnofsky performance status
  • 0 views
  • 25 Jan, 2021
  • 1 location