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Found 26 clinical trials
Transplants With Unlicensed Preserved Cord Blood

Background Cord blood transplants can treat cancers and other diseases in children and adults. The U.S. Food and Drug Administration (FDA) requires cord blood to be collected and stored under certain safety standards. However, most available cord blood units were collected before the FDA set these standards. These units may …

cancer
  • 149 views
  • 25 Jul, 2021
  • 1 location
Multivirus-specific T-cell Transfer Post SCT vs AdV CMV and EBV Infections

Haematopoietic stem cell transplantation (HSCT) can expose patients to a transient but marked immunosuppression, during which viral infections are an important cause of morbidity and mortality. Adoptive transfer of virus-specific T cells is an attractive approach to restore protective T-cell immunity in patients with refractory viral infections after allogeneic HSCT. …

  • 0 views
  • 24 Jun, 2021
  • 12 locations
Hematopoietic Stem Cell Therapy for Inflammatory Multiple Sclerosis Failing Alternate Approved Therapy

The purpose of this study is to assess the efficacy of autologous PBSCT versus FDA approved standard of care (i.e. interferon, glatiramer acetate, mitoxantrone, natalizumab, fingolimod, or tecfidera) for inflammatory MS failing alternate approved therapy. Disease progression, defined as a 1-point increase in the Expanded Disability Status scale (EDSS) on …

fingolimod
dimethyl fumarate
copaxone
disease or disorder
rebif
  • 120 views
  • 08 Nov, 2020
  • 1 location
Decitabine+BUCY vs BUCY Conditioning Regimen for MLL+ Acute Leukemia Undergoing Allo-HSCT

Recent studies demonstrated that allogeneic hematopoietic stem cell transplantation (allo-HSCT) could be a valuable treatment choice for mixed-lineage-leukemia (MLL)-rearranged acute leukemia. Unfortunately, some patients relapsed after allo-HSCT. In this prospective randomized controlled study, the safety and efficacy of Decitabine + BUCY and BUCY myeloablative conditioning regimens in MLL+ acute leukemia …

busulfan
conditioning regimen
decitabine
myeloablative conditioning
leukemia
  • 7 views
  • 22 Jan, 2021
  • 1 location
Long-term Evaluation and Follow-up Care of Patients Treated With Stem Cell Transplants

This study will provide follow-up evaluation and care of patients who have undergone allogeneic (donor) stem cell transplantation at the NIH Clinical Center. Patients are monitored for their response to treatment, disease relapse, and later-occurring effects of the transplant. Patients between 10 and 80 years of age who received a …

electrocardiogram
stem cell transplantation
computerized tomography
cancer
multiple gated acquisition scan
  • 49 views
  • 26 Jul, 2021
  • 1 location
Submission of Stem Cell Transplant Data to CIBMTR and NMDP

informed consent to participate in the study before starting pre-transplant conditioning. - Donors are asked to give informed consent to participate before starting preparation

transplant conditioning
  • 117 views
  • 07 Nov, 2020
  • 1 location