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Found 26 clinical trials
TT52CAR19 Therapy for B-cell Acute Lymphoblastic Leukaemia (B-ALL)

are to be used in a time-limited manner for their anti-leukaemia effects and then depleted by standard pre- transplant conditioning.

  • 0 views
  • 27 Jan, 2021
  • 1 location
Early Human Leukocyte Antigen (HLA) Matched Sibling Hematopoietic Stem Cell Transplantation

evaluation and make the arrangements for the transplant. Once they are found to be eligible for transplant, participants will be admitted to the hospital and will start transplant conditioning. Conditioning

arteriopathy
hemoglobinopathy
transplant conditioning
chest syndrome
stroke
  • 23 views
  • 26 Jul, 2021
  • 9 locations
Stem Cell Transplant in Patients With Severe Sickle Cell Disease

This is a prospective pilot study of matched-related donor allogeneic stem cell transplantation in adults with severe sickle cell disease using a matched-sibling PBSC graft with a non-myeloablative conditioning regimen (Alemtuzumab).

sirolimus
transplant conditioning
analgesia
chest syndrome
iron overload
  • 30 views
  • 02 Apr, 2021
  • 1 location
Umbilical Cord Blood Transplantation From Unrelated Donors

This study is a single-center, treatment protocol with 4 possible preparative regimens, designed to validate the process of umbilical cord blood stem cell transplantation at our institution.

cyclophosphamide
lymphoma
follicular lymphoma
treatment-related aml
severe aplastic anemia
  • 80 views
  • 16 May, 2021
  • 1 location
Study of Iomab-B vs. Conventional Care in Older Subjects With Active Relapsed or Refractory Acute Myeloid Leukemia

The primary objective of this study is to demonstrate the efficacy of Iomab-B, in conjunction with a Reduced Intensity Conditioning (RIC) regimen and protocol-specified allogeneic hematopoietic stem cell transplant (HCT), versus Conventional Care in patients with Active, Relapsed or Refractory Acute Myeloid Leukemia (AML).

refractory acute myeloid leukemia (aml)
direct bilirubin
flow cytometry
myeloid leukemia
stem cell transplantation
  • 0 views
  • 11 Apr, 2021
  • 24 locations
Allogeneic Hematopoietic Stem Cell Transplant for People With Primary Immunodeficiency Diseases

Background During a transplant, blood stem cells from one person are given to someone else. The cells grow into the different cells that make up the immune system. This can cure people with certain immunodeficiencies. But transplant has many risks and complications. Objective To see if stem cell transplant can …

cyclophosphamide
conjugated bilirubin
mycophenolate mofetil
blood transfusion
ejection fraction
  • 0 views
  • 16 Jul, 2021
  • 1 location
Lactobacillus Plantarum in Preventing Acute Graft Versus Host Disease in Children Undergoing Donor Stem Cell Transplant

This randomized phase III trial studies how well Lactobacillus plantarum works in preventing acute graft versus host disease in children undergoing donor stem cell transplant. Lactobacillus plantarum may help prevent the development of gastrointestinal graft versus host disease in children, adolescents, and young adults undergoing donor stem cell transplant.

graft versus host disease
cell transplantation
  • 13 views
  • 25 Jul, 2021
  • 28 locations
RICE-ibrutinib in Relapsed DLBCL

This is a multicentre, open-label, phase II study of ibrutinib 560 mg in combination with R-ICE for treatment of transplant-eligible relapsed/refractory diffuse large B-cell lymphoma.

glomerular filtration rate
ibrutinib
lymphoma
gilbert's syndrome
anthracycline
  • 174 views
  • 21 Jan, 2021
  • 4 locations
Allogeneic Hematopoietic Stem Cell Transplant for GATA2 Mutations

Background GATA2 deficiency is a disease caused by mutations in the GATA2 gene. It can cause different types of leukemia and other diseases. Researchers want to see if a stem cell transplant can be used to treat this condition. A stem cell transplant will give stem cells from a matching …

filgrastim
cyclophosphamide
conjugated bilirubin
mycophenolate mofetil
ejection fraction
  • 26 views
  • 29 May, 2021
  • 1 location
Addition of Gemcitabine to Pre Allo-HSCT Conditioning for Acute Lymphoblastic Leukemia

The main purpose of the project is to evaluate the disease free survival and overall survival in patients diagnosed with acute lymphoblastic leukemia undergoing allogeneic hematopoietic stem cell transplantation (allo-HSCT) adding gemcitabine to the standard institutional conditioning regimen based on two alkylating drugs, reduced busulfan and cyclophosphamide (reduced BUCY 2).

  • 1 views
  • 24 Jan, 2021
  • 1 location