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Found 25 clinical trials
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A Multicenter Access and Distribution Protocol for Unlicensed Cryopreserved Cord Blood Units (CBUs) for Transplantation in Pediatric and Adult Patients with Hematologic Malignancies and Other Indications

Background: Cord blood transplants can treat cancers and other diseases in children and adults. The U.S. Food and Drug Administration (FDA) requires cord blood to be collected and stored under certain safety standards. However, most available cord blood units were collected before the FDA set these standards. These units may …

aplastic anemia
anemia studies
myelodysplastic syndrome (mds)
anemia
myelodysplastic syndromes
  • 51 views
  • 22 Dec, 2020
  • 1 location
TEAM (Thiotepa Etoposide Cytosar Melphalan ) for AutoSCT in Lymphoma

, -2 and melphalan 140 mg/m2 on day -1, pre transplantation conditioning regimen may allow transplantation with lower transplant related toxicity and thus improve outcome in this setting. Toward this

cell transplantation
hodgkin's disease
etoposide
thiotepa
melphalan
  • 0 views
  • 28 Oct, 2020
  • 1 location
Allograft for Sickle Cell Disease and Thalassemia

>Transplant Conditioning Regimen - Immunosuppression without myeloablation: Patients will receive conditioning sufficient to allow donor lympho-hematopoietic engraftment without complete marrow

  • 28 views
  • 24 Jan, 2021
  • 1 location
Pilot Study of Reduced-Intensity Hematopoietic Stem Cell Transplant of DOCK8 Deficiency

Background -DOCK8 deficiency is a genetic disorder that affects the immune system and can lead to severe recurrent infections and possible death from infections or certain types of cancers, including blood cancers. A stem cell transplant is a life-saving treatment for this condition. In this study we are evaluating the …

  • 1 views
  • 17 Jan, 2021
  • 1 location
T Cell Depleted Allogeneic Hematopoietic Stem Cell Transplantation Conditioned With a Reduced Intensity Regimen in Patients With Hematologic Malignancies and Aplastic Anemia

The main purpose of this study is to learn if a new combination of chemotherapy, in combination with low-dose radiation, will be safe for the patient, and at the same time provide the best opportunity to cure the bone marrow cancer. The combination of chemotherapy and radiation described in the …

  • 13 views
  • 24 Jan, 2021
  • 2 locations
Campath/Fludarabine/Melphalan Transplant Conditioning for Non-Malignant Diseases

The hypothesis for this study is that a preparative regimen that maximizes host immunosuppression without myeloablation will be well tolerated and sufficient for engraftment of donor hematopoietic cells. It is also to determine major toxicities from these conditioning regimens, within the first 100 days after transplantation.

preparative regimen
hemoglobin s
campath
thalassemia
graft-versus-host disease
  • 142 views
  • 24 Jan, 2021
  • 20 locations
BMT-06: Study of Intensity Modulated Total Marrow Irradiation (IM-TMI)

Pre-transplant conditioning will include targeted total marrow irradiation (TMI) at a dose of 6Gy. Graft-versus-host disease prophylaxis will include cyclophosphamide 50 mg/kg on Day +3 and 4

cytopenia
total body irradiation
adult t-cell leukemia/lymphoma
fludarabine
transplant conditioning
  • 18 views
  • 23 Jan, 2021
  • 1 location
Tocilizumab for the Prevention of Graft Failure and GVHD in Haplo-Cord Transplantation

The purpose of this study is to evaluate the safety of reducing and ultimately eliminating anti-thymocyte globulin (ATG) from the haplo-cord transplant conditioning regimen and replacing it with

blood disorder
lymphoma
chronic lymphocytic leukemia
total body irradiation
antithymocyte globulin
  • 0 views
  • 26 Oct, 2020
  • 1 location
TT52CAR19 Therapy for B-cell Acute Lymphoblastic Leukaemia (B-ALL)

are to be used in a time-limited manner for their anti-leukaemia effects and then depleted by standard pre- transplant conditioning.

  • 0 views
  • 04 Dec, 2020
  • 1 location
18-FLT PET/MR Imaging to Predict Graft Failure and GVHD in Bone Marrow Transplant Patients

and/or irradiation can be given since patients are subsequently rescued from the severe myelosuppression induced by the pre-transplant conditioning regimen by the infusion of healthy hematopoietic

multiple myeloma
cancer
allogeneic bone marrow transplantation
total body irradiation
acute graft-versus-host disease
  • 23 views
  • 24 Jan, 2021
  • 1 location