Filter By
Clear all Advanced
I am/have/had
added new label for I am/have/had
I am looking for
added new label for I am looking for
Advanced Filters
Found 39 clinical trials
The Role of Hepcidin as a Biomarker to Predict Successful Renal Transplantation

High hepcidin concentrations indicate that iron is blocked from secretion from the reservoir. Hepcidin may be useful in prediction functional iron utilization in renal failure patients. Hepcidin is also associated with chronic renal failure and residual renal function in dialysis patients. Recent studies have shown that hepcidin is a potential …

  • 26 Jan, 2021
  • 1 location
Cardiopulmonary Bypass Induced Red Blood Cell Lysis

Studying the dynamics of red blood cell lysis, pfH, protective proteins and organ injury, limits will be set for safe levels of pfH following the use of CPB. These results will be compared to existing laboratory-based methods for determining red blood cell damage to predict CPB assist device safety. Further, …

cardiopulmonary bypass
mitral valve replacement
  • 07 Jul, 2022
Anemia in Patients With Endocarditis (ANIE)

Prospective study of prevalence and deep charecterization of anemia in patients with endocarditis from diagnosis undtill 6 months after discharge.

Accepts healthy volunteers
  • 14 May, 2022
  • 1 location
bAriatric sUrgery Registration in wOmen of Reproductive Age

The use of bariatric surgery has risen subsequently over the last decade, especially in women of reproductive age. (Unplanned) pregnancies in this subgroup are not rare because of e.g. an increased fertility (because of the weight loss) and a possible ineffectiveness of contraceptives (because of a malabsorption in the intestine). …

high risk pregnancy
  • 15 May, 2021
  • 1 location
Liver Toxicity in Lung Cancer Patients Treated With Immune-checkpoint Inhibitors.

Immune-checkpoint inhibitors have recently become available as a new therapy for a variety of cancers. This drugs function by boosting the anti-cancer immune response, but unfortunately, may cause off-target, non-specific immune activation, resulting in liver and gut toxicity. In order to understand the development of liver immune-related adverse events we …

lung carcinoma
advanced lung cancer
cancer chemotherapy
  • 22 Mar, 2022
  • 3 locations
Glucose Brain and Microbiota

The accumulation of iron is known to affect the functions of the liver, adipose tissue and muscle. The brain is a well-known place of iron deposition, which is associated with cognitive parameters of subjects with obesity. The hypothesis is that certain parameters related to glucose metabolism (glycemic variability, the circulating …

bariatric surgery
hemoglobin a1c
glycosylated hemoglobin
  • 24 Jul, 2021
  • 1 location
Gut-Brain-axis: Targets for Improvement of Cognition in the Elderly

Cognitive disorders increase with age and in the presence of metabolic diseases such as Type 2 Diabetes Mellitus (T2DM). In addition, digestive disorders, changes in dietary pattern and decreased activity negatively influence the microbiome. The hypothesis is that pharmacological intervention with metformin will modify the composition of the gut microbiota …

type 2 diabetes mellitus
continuous glucose monitoring
  • 30 May, 2021
  • 1 location
Immune Checkpoint Inhibitors Nephrotoxicity

In recent years, immunotherapy has been postulated as one of the most effective strategy in the fight against cancer. The greatest success in this field has been achieved through the inhibition of molecules involved in the brake of the adaptive immune response. The compounds capable of blocking the action of …

  • 04 Jun, 2021
  • 2 locations
Inter-relationships Among Glucose, Brain, Gut Microbiota and MicroRNAs (IRONmiRNA). (IRONmiRNA)

The brain is a recognized target of iron deposition. This process is enhanced by the presence of obesity and hyperglycemia and impacts cognitive functions. There is evidence suggesting that the gut microbiota composition modulates this process. It has been proposed that microRNAs are mediators in the dialogue between the composition …

Accepts healthy volunteers
bariatric surgery
  • 16 May, 2022
  • 1 location