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Found 72 clinical trials
Embolization of Middle Meningeal Artery in Chronic Subdural Hematoma (ELIMINATE)

Chronic subdural hematoma (cSDH) is a common neurological affliction which affects mostly frail and elderly patients. Surgical evacuation by using burr hole craniostomy (BHC) is the most frequently used treatment but carries a recurrence rate varying between 10-30% in the literature. Especially in this frail population re-operation is undesirable. Embolization …

  • 04 Oct, 2022
  • 1 location
Role of Blood Management in Perioperative Outcomes

There is currently limited information regarding the role of blood management in the benign gynecologic population and specifically, in patients who are scheduled to undergo surgery for fibroids and/or abnormal uterine bleeding. A thorough search through PubMed and did not reveal any studies on this issue. In 2019 at …

  • 04 Oct, 2022
  • 1 location
Tranexamic Acid to Reduce Infection After Gastrointestinal Surgery

This international, multicentre, pragmatic, double-blind, placebo-controlled, randomised trial of TxA versus placebo will enrol 3,300 patients throughout Australia and internationally. This is an effectiveness trial - some elements of the trial are deliberately left to the perioperative clinicians' discretion in order to reflect usual practice and maximise generalisability.

  • 28 Jan, 2021
  • 1 location
The HeLiX (Hemorrhage During Liver Resection: traneXamic Acid) Trial (HeLiX)

This is a Phase III multicentre randomized controlled trial (RCT) to evaluate the impact of tranexamic acid (TXA) on perioperative blood transfusion in patients undergoing liver resection. The

liver surgery
blood transfusion
primary cancer
  • 23 Mar, 2022
  • 10 locations
STOP-MSU: Stopping Haemorrhage With Tranexamic Acid for Hyperacute Onset Presentation Including Mobile Stroke Units

randomisation to either intravenous tranexamic acid or placebo and will test the hypothesis that in patients with spontaneous ICH, treatment with tranexamic acid within 2 hours of onset will reduce haematoma

intracranial hemorrhage
  • 20 Apr, 2022
  • 24 locations
DEPOSITION - Decreasing Postoperative Blood Loss by Topical vs. Intravenous Tranexamic Acid in Open Cardiac Surgery (DEPOSITION)

The aim is to conduct a double-dummy multi-centre randomized controlled clinical trial of application of topical dose of tranexamic acid (TxA) versus the usual intravenous TxA in patients

coronary artery bypass graft
cardiopulmonary bypass
postoperative bleeding
postoperative hemorrhage
tranexamic acid
  • 04 Oct, 2022
  • 7 locations
World Maternal Antifibrinolytic Trial_2 (WOMAN-2)

, tranexamic acid reduces deaths due to bleeding in women with PPH by almost one third. However, for many women, treatment of PPH is too late to prevent death and severe morbidities. Over one-third of pregnant

  • 04 Oct, 2022
  • 23 locations
Clinical Randomisation of an Anti-fibrinolytic in Symptomatic Mild Head Injury in Older Adults

Tranexamic acid (TXA) reduces head injury deaths. The CRASH-4 trial aims to assess the effects of early intramuscular TXA on intracranial haemorrhage, disability, death, and dementia in older

head injury
  • 04 Oct, 2022
  • 2 locations
Platelet Transfusions in Hematopoietic Stem Cell Transplantation (The PATH III Trial) (PATH)

It is hypothesized that a strategy using prophylactic oral and intravenous Tranexamic Acid (TXA) with therapeutic platelet transfusions (if required) is safe and more effective than prophylactic

tranexamic acid
hematologic malignancy
cell transplantation
  • 04 Oct, 2022
  • 4 locations
Tranexamic Acid in Traumatic Brain Injury

In this study, our aim is to investigate the role of tranexamic acid for modulating the inflammation in patients with traumatic brain injury (TBI).

  • 06 Jun, 2022
  • 1 location