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Found 51 clinical trials
Capecitabine-based Chemoradiotherapy in Combination With the IL-1 Receptor Antagonist Anakinra for Rectal Cancer Patients (ACO/ARO/AIO-21)

The ACO/ARO/AIO-21 investigator-driven, open-labeled, phase I drug re-purposing trial will assess whether the IL-1 receptor antagonist Anakinra can be safely combined with fluoropyrimidine-based chemoradiotherapy (CRT) in patients with rectal cancer.

total mesorectal excision
permanent colostomy
abdominoperineal resection
chemoradiotherapy
adenocarcinoma
  • 0 views
  • 04 Oct, 2022
  • 1 location
TAS-102 With Concurrent Radiation for the Treatment of Untreated Resectable Stage II-III Rectal Cancer

This phase 1b trial studies the side effects and best dose of TAS-102 when given together with radiation therapy in treating patients with stage II-III rectal cancer that has not been treated and can be removed by surgery (resectable). Drugs used in chemotherapy, such as TAS-102, work in different ways …

cancer
rectal carcinoma
tas-102
metastasis
x-rays
  • 0 views
  • 27 May, 2022
  • 1 location
Patients With Rectal Cancer: a "Wait-and-see" Approach

Patients with histologically proven adenocarcinoma of the rectum will receive pelvic radiotherapy to a dose of 45Gy in 25 fractions with a tumor boost to a dose of 9Gy in 5 fractions (thus total of 54Gy/30Fx to the primary tumor), combined with radio sensitizing chemotherapy. Patients will then be closely …

metastasis
neutrophil count
adenocarcinoma
  • 8 views
  • 07 Oct, 2022
  • 4 locations
Comparison Between Results of 2 Laparoscopic Surgical Procedures in Operable Colon Cancer Cases in Upper Egypt

The investigators will assess and compare Surgical, pathological and oncological outcomes between two laparoscopic procedures conventional colectomy versus complete mesocolic excision for operable colon cancer cases in Upper Egypt

  • 0 views
  • 04 Oct, 2022
  • 1 location
Watchful Waiting for Complete Responders to Therapy in Rectal Cancer

The purpose of this project is to determine if in a selected group of patients, at higher risk of wound dehiscence and other complications, treatment by local excision and management by a "watchful waiting" or an initial "non-operative management" approach, with an offer of radical resection only to those patients …

adenocarcinoma
local excision
  • 0 views
  • 07 Oct, 2022
  • 1 location
Short Course Radiation Therapy and Combination Chemotherapy for the Treatment of Stage II-III Rectal Cancer

This phase I trial investigates how well short-course radiation therapy followed by combination chemotherapy works in treating patients with stage II-III rectal cancer. Radiation therapy uses high energy x-rays to kill tumor cells and shrink tumors. Chemotherapy drugs, such as leucovorin, fluorouracil, oxaliplatin, and capecitabine, work in different ways to …

  • 0 views
  • 24 Mar, 2022
  • 1 location
Neoadjuvant Chemoradiotherapy and Consolidation Chemotherapy for Rectal Cancer: A Randomized Controlled Trial

The purpose of this protocol is to compare neoadjuvant chemoradiation plus consolidation chemotherapy before surgical resection with the standard neoadjuvant chemoradiation followed by surgical resection and adjuvant chemotherapy in patients with rectal cancer.

endoscopy
folfox regimen
oxaliplatin
chemoradiotherapy
adenocarcinoma
  • 0 views
  • 07 Oct, 2022
  • 1 location
BReak Interval Delayed Surgery for Gastrointestinal Extraperitoneal Rectal Cancer (BRIDGE)

This is a randomized multicentric clinical trial in patients affected by resectable rectal cancer, cT2N1-2, cT3N0-2, MRF -, aiming to evaluate the impact of the interval between chemoradiotherapy and surgery on the pathological response. Patients will undergo a neoadjuvant chemoradiotherapy treatment and those achieving a major or complete clinical and …

chemoradiotherapy
adenocarcinoma
  • 0 views
  • 25 Mar, 2022
  • 1 location
Validation of the French Version of the Low Anterior Resection Syndrome (LARS) Among Rectal Cancer Patients

Oncological rectal cancer outcomes have improved considerably because of optimal surgery by total mesorectal excision in conjunction with multidisciplinary team management by selective

  • 0 views
  • 25 Jan, 2021
  • 8 locations
Perioperative and Postoperative Evaluation of Rectal and Urogenital Function in Patients Undergoing Rectal Resection (PERIFUNC)

The aim of this study is the systematic analysis of the development of perioperative rectal and urogenital function in patients undergoing rectal resection with total mesorectal excision and the

  • 0 views
  • 14 Mar, 2022
  • 1 location