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Found 51 clinical trials
Induction Chemotherapy for MRF-negative, Moderate-risk, Resectable Middle and Low Rectal Cancer

This study is designed to test the Safety and efficacy of induction and individualized neoadjuvant chemotherapy based on oxaliplatin combined with fluorouracil for MRF-negative, moderate-risk and initially resectable middle and low rectal cancer.

adenocarcinoma
capecitabine
metastasis
adenocarcinoma of rectum
total mesorectal excision
  • 0 views
  • 28 Feb, 2022
  • 1 location
Total Neoadjuvant Therapy With mFOLFOX and Short-course Radiation in Resectable Rectal Cancer

This is phase 2 trial of neoadjuvant therapy and short-course radiotherapy in resectable rectal cancer.

adenocarcinoma
renal function
transrectal ultrasound
endoscopy
fluorouracil
  • 0 views
  • 25 Nov, 2021
  • 1 location
A Phase II Study of Neoadjuvant Nivolumab Plus Ipilimumab and Short-Course Radiation in MSI-H/dMMR Locally Advanced Rectal Adenocarcinoma

This phase II trial investigates the effect of nivolumab and ipilimumab when given together with short-course radiation therapy in treating patients with rectal cancer that has spread to other places in the body (advanced). Immunotherapy with monoclonal antibodies, such as nivolumab and ipilimumab, may help the body's immune system attack …

  • 0 views
  • 21 Oct, 2022
  • 78 locations
SHOrt Course Radiation and TASOX (TAS102 Plus Oxaliplatin) Chemotherapy in Operable Rectal Cancer (SHORT)

TASOX can be safely and efficaciously delivered after short course radiation, resulting in significant pathologic downstaging, allowing for an R0 pelvic resection, and providing local control in appropriately selected stage II/III rectal cancer patients treated with contemporary TME-based surgery.

adenocarcinoma
pelvic mri
oxaliplatin
metastasis
adenocarcinoma of rectum
  • 0 views
  • 04 Oct, 2022
  • 3 locations
A Phase II Study to Test the Efficacy of AB928 (Dual Adenosine Receptor Antagonist) and AB122 (a PD1 Checkpoint Inhibitor) in Combination With Short Course Radiotherapy and Consolidation Chemotherapy for Rectal Cancer. (PANTHER)

Enrolled patients will receive upfront (week 1) short-course radiotherapy to gross pelvic disease (25Gy in 5fx) in combination with AB928 (150 mg orally, once daily as part of a continuous dose regimen). This will be followed by consolidation chemotherapy (weeks 3-20) with mFOLFOX x9 cycles in combination with AB928 and …

adenocarcinoma
folfox regimen
total mesorectal excision
pelvic radiation
  • 0 views
  • 06 May, 2022
  • 1 location
Total Neoadjuvant trEatment to Increase the Clinical Complete reSponse Rate for diStal Locally Advanced Rectal Cancer (TESS) (TESS)

This is a open-label, single-arm study to investigate the safety and efficacy of total neoadjuvant treatment (TNT) in patients with locally advanced resectable rectal cancer.

adenocarcinoma
capecitabine
metastasis
total mesorectal excision
oxaliplatin
  • 0 views
  • 13 Oct, 2022
  • 1 location
Brazilian Total Neoadjuvant Therapy Trial

Standard therapy for localized rectal cancer includes chemotherapy and radiation therapy, followed by a "recovery" period of 7-12 weeks, surgery and adjuvant chemotherapy for 3-6 months. Even though this protocol achieves high cure rates, many patients need a rectal amputation with placement of definitive colostomies. About 10-20% of patients have …

  • 0 views
  • 27 Oct, 2021
  • 1 location
A Study of Total Neoadjuvant Therapy for High-risk Locally Advanced Rectal Cancer

A Phase II Study of Total Neoadjuvant Therapy for High-risk Locally Advanced Rectal Cancer

adenocarcinoma
chemoradiotherapy
oxaliplatin
capecitabine
total mesorectal excision
  • 25 views
  • 24 Mar, 2022
  • 1 location
Multicenter Study on Postoperative Urinary and Sexual Function During Laparoscopic Functional Total Mesorectum Excision

Urinary and sexual dysfunctions are among the most common complications in rectal cancer surgery. The aim of this study was to investigate the protective effect of laparoscopic functional total mesorectum excision (FTME) on urinary and sexual function in male patients with mid-low rectal cancer. This is a prospective, single-arm, multicenter, …

total mesorectal excision
  • 0 views
  • 08 Nov, 2021
  • 1 location
Timing to Minimally Invasive Surgery After Neoadjuvant Chemoradiotherapy for Rectal Cancer (TiMiSNAR)

The trial is a multicenter, prospective, randomized controlled, unblinded, parallel-group trial comparing standard and delayed surgery after neoadjuvant chemoradiotherapy for the curative treatment of rectal cancer. Three-hundred and thirty-two patients will be randomized on an equal basis to either robotic-assisted/standard laparoscopic rectal cancer surgery after 8 weeks or robotic-assisted/standard laparoscopic …

adenocarcinoma
chemoradiotherapy
cancer surgery
abdominoperineal resection
adenocarcinoma of rectum
  • 1 views
  • 28 Feb, 2022
  • 13 locations