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Found 98 clinical trials
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Co-Infusion of Umbilical Cord Blood and Haploidentical CD34+ Cells Following Nonmyeloablative Conditioning as Treatment for Severe Aplastic Anemia and MDS Associated with Severe Neutropenia Refractory to Immunosuppressive Therapy

medicines, for transfusions of red blood cells and platelets, and for collecting blood samples. Preparatory chemotherapy (fludarabine, cyclophosphamide and anti-thymocyte globulin) and total body

anemia
anemia studies
aplastic anemia
myelodysplastic syndrome (mds)
myelodysplastic syndromes
  • 48 views
  • 22 Dec, 2020
  • 1 location
featured
Nonmyeloablative Haploidentical Peripheral Blood Mobilized Hematopoietic Precursor Cell Transplantation for Sickle Cell Disease

Background: Peripheral blood stem cell transplantation procedures are used for people with sickle cell disease. Researchers want to improve the success and reduce the complications for these procedures. This might allow more people to have a transplant. Objective: To see if a new transplant regime is effective, safe and well …

stroke
red blood cell disorder
cell transplantation
sickle cell disease
  • 57 views
  • 22 Dec, 2020
  • 1 location
Risk-Adjusted Combination Chemotherapy in Treating Young Patients With Acute Lymphoblastic Leukemia

RATIONALE: Drugs used in chemotherapy work in different ways to stop the growth of cancer cells, either by killing the cells or by stopping them from dividing. Giving more than one drug (combination chemotherapy) may kill more cancer cells. A donor stem cell transplant may replace the patient's immune cells …

asparaginase
mercaptopurine
prednisone
daunorubicin
lymphoid leukemia
  • 0 views
  • 07 Nov, 2020
  • 1 location
Allogeneic Transplantation for Pediatric Leukemias With Unrelated Donors

The study proposes the use of Fludarabine, Busulfan, Anti Thymocyte Globulin Rabbit (ATG) and Total Body Irradiation as a preparative regimen before hematopoietic stem cell transplant

fludarabine
ejection fraction
total body irradiation
cancer
hypodiploidy
  • 10 views
  • 07 Nov, 2020
  • 1 location
Efficacy of R-CHOP vs R-CHOP/R-DHAP in Untreated MCL

followed by total body irradiation [TBI]/high dose cytarabine [ARA-C]/melphalan-peripheral blood stem cell transplantation (TAM-PBSCT) can improve the time to treatment failure compared to CHOP

r-chop
rituximab
measurable disease
melphalan
doxorubicin
  • 134 views
  • 07 Nov, 2020
  • 2 locations
Randomised Prospective Comparison of the NMA Allograft and the Traditional Allograft in Acute Myeloid Leukaemia

The allograft of marrow in its technique of reference (myélo-ablative (MA) condition by cyclophosphamide and total body irradiation (TBI) with strong amounts) therapeutic is recognized

daunorubicin
idarubicin
secondary acute myeloid leukemia
total body irradiation
cyclophosphamide
  • 18 views
  • 07 Nov, 2020
  • 1 location
Reduced Toxicity Fludarabine (Flu) + Cyclophosphamide (CPM) + Rabbit Antithymocyte Globulin (rATG) Conditioning Regimen for Unrelated Donor Transplantation in Severe Aplastic Anemia (SAA)

more effective in preventing graft versus host disease (GVHD) and rejection of organ transplants. As the fludarabine based conditioning regimens without total body irradiation have been

fludarabine
thymoglobulin
aplastic anemia
cell transplantation
neutrophil count
  • 29 views
  • 07 Nov, 2020
  • 1 location
Respiratory Side Effects of Busulfan High Dose Chemotherapy in a Pediatric Population

Recently, several conditioning regimens did not include total body irradiation (TBI) anymore, especially in the case of young children due to cognitive sequelae and late effects on growth

  • 6 views
  • 07 Nov, 2020
  • 1 location
Haploidentical Transplant for People With Chronic Granulomatous Disease (CGD) Using Alemtuzumab Busulfan and TBI With Post-Transplant Cyclophosphamide

Background CGD causes infections and inflammation. The only cure currently is a bone marrow transplant. Most often a perfectly matched bone marrow donor is used. Researchers want to see if they can lower the risks of using a mismatched donor. Objectives To see if it is safe to use a …

alemtuzumab
cyclophosphamide
stem cell transplantation
bone marrow transplant
blood test
  • 1 views
  • 28 Jun, 2021
  • 1 location
Pediatric Guideline Adherence and Outcomes- Argentina

Pediatric traumatic brain injury (TBI) is the leading killer of children worldwide but effective treatments for TBI are limited. Although evidenced-based pediatric TBI guidelines exist, adherence to these guidelines is low,leading us to develop a new Pediatric Guideline Adherence and Outcomes (PEGASUS) program to increase TBI guideline adherence. We propose …

traumatic brain injury
coma
head ct
  • 0 views
  • 26 Jan, 2021
  • 17 locations