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Found 78 clinical trials
Featured trial
Co-Infusion of Umbilical Cord Blood and Haploidentical CD34+ Cells Following Nonmyeloablative Conditioning as Treatment for Severe Aplastic Anemia and MDS Associated with Severe Neutropenia Refractory to Immunosuppressive Therapy

medicines, for transfusions of red blood cells and platelets, and for collecting blood samples. Preparatory chemotherapy (fludarabine, cyclophosphamide and anti-thymocyte globulin) and total body

myelodysplastic syndromes
anemia
aplastic anemia
anemia studies
myelodysplastic syndrome (mds)
  • 54 views
  • 22 Dec, 2020
  • 1 location
Featured trial
Nonmyeloablative Haploidentical Peripheral Blood Mobilized Hematopoietic Precursor Cell Transplantation for Sickle Cell Disease

Background: Peripheral blood stem cell transplantation procedures are used for people with sickle cell disease. Researchers want to improve the success and reduce the complications for these procedures. This might allow more people to have a transplant. Objective: To see if a new transplant regime is effective, safe and well …

stroke
cell transplantation
red blood cell disorder
sickle cell disease
  • 83 views
  • 22 Dec, 2020
  • 1 location
TLI, TBI, ATG & Hematopoietic Stem Cell Transplantation and Recipient T Regs Therapy in Living Donor Kidney Transplantation

This study will determine whether a preparatory regimen including total lymphoid irradiation (TLI), total body irradiation (TBI), anti-thymocyte globulin (ATG) and infusion of the donor

  • 6 views
  • 27 May, 2022
  • 2 locations
Haploidentical Transplant for People With Chronic Granulomatous Disease (CGD) Using Alemtuzumab, Busulfan and TBI With Post-Transplant Cyclophosphamide

Background CGD causes infections and inflammation. The only cure currently is a bone marrow transplant. Most often a perfectly matched bone marrow donor is used. Researchers want to see if they can lower the risks of using a mismatched donor. Objectives To see if it is safe to use a …

cyclophosphamide
stem cell transplantation
busulfan
blood test
alemtuzumab
  • 7 views
  • 04 Oct, 2022
  • 1 location
Pediatric Guideline Adherence and Outcomes- Argentina

Pediatric traumatic brain injury (TBI) is the leading killer of children worldwide but effective treatments for TBI are limited. Although evidenced-based pediatric TBI guidelines exist, adherence to these guidelines is low,leading us to develop a new Pediatric Guideline Adherence and Outcomes (PEGASUS) program to increase TBI guideline adherence. We propose …

head ct
traumatic brain injury
coma
  • 0 views
  • 19 Feb, 2022
  • 16 locations
ASCT After a Rituximab/Ibrutinib/Ara-c Containing iNduction in Generalized Mantle Cell Lymphoma

The primary objective of the the trial is to establish one of three study arms, as future standard based on the comparison of the investigator-assessed failure-free survival.

filgrastim
chop regimen
ibrutinib
neutrophil count
mantle cell lymphoma
  • 120 views
  • 23 Feb, 2022
  • 52 locations
Cognitive Support Technology for Postsecondary Students With Traumatic Brain Injuries

This study will fill important knowledge gaps in the availability of best practices that use innovative methods to integrate the cognitive and vocational needs of students with TBI who will be transitioning from 2- and 4-year postsecondary education to employment. Best practices exist from the assistive technology (AT) field to …

  • 0 views
  • 29 Sep, 2021
  • 1 location
VR Cognitive Rehabiliation for Pediatric TBI

Childhood traumatic brain injury (TBI) poses significant impairment in children's executive functions (EFs) for moderate to severe injuries, yet interventions specifically designed for children's EF rehabilitation post-TBI and rigorous clinical trials to establish the efficacy of such interventions remain unavailable. In this study, the investigators will conduct a randomized clinical …

cognitive training
resuscitation
coma
traumatic brain injury
  • 0 views
  • 04 Oct, 2022
  • 1 location
A Phase II Single-arm Study of Total Body Irradiation With Linac Based VMAT and IGRT

Single institution study of safety of linac based VMAT TBI for myeloablative treatment in hematologic malignancies.

calcium
hla typing
total body irradiation
transplant conditioning
  • 0 views
  • 21 Mar, 2022
  • 1 location
Umbilical Cord Blood Transplant, Cyclophosphamide, Fludarabine, and Total-Body Irradiation in Treating Patients With Hematologic Disease

This phase II trial studies how well giving an umbilical cord blood transplant together with cyclophosphamide, fludarabine, and total-body irradiation (TBI) works in treating patients with

burkitt's lymphoma
follicular lymphoma
mycophenolate
white blood cells
fludarabine
  • 129 views
  • 07 Oct, 2022
  • 1 location