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Found 45 clinical trials
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A phase II study of Antineoplastons A10 And AS2-1 Private In Children With Primary Malignant Brain Tumors

A phase II study of Antineoplastons A10 And AS2-1 Private In Children With Primary Malignant Brain Tumors

  • 136 views
  • 08 Nov, 2020
  • 1 location
Primaquine Enantiomers in G6PD Deficient Human Volunteers

This study is a single center, prospective, cross-over phase 1 trial. Eighteen subjects will be enrolled in the study evaluating the metabolism, pharmacokinetic behavior and tolerability of primaquine enantiomers and placebo over the course of 5 days.

  • 6 views
  • 25 Jan, 2021
  • 1 location
Study of IV VTS-270 for Infantile Liver Disease Associated With Niemann-Pick Disease Type C

Niemann-Pick disease, type C (NPC) is a lethal, autosomal recessive, lysosomal storage disorder characterized by neurodegeneration in early childhood and death in adolescence. NPC results from mutation of either the Niemann-Pick C1 disease (NPC1) (~95% of cases) or NPC2 genes. NPC is characterized by the endolysosomal storage of unesterified cholesterol …

  • 4 views
  • 25 Jan, 2021
  • 1 location
GE-148-002: A Phase 2 Open-label Single-Center Study to Assess GE-148 (18F) Injection PET Imaging to Detect Localized Prostate Cancer

Background: - GE-148 (18F) is a new drug that is designed to attach to prostate cancer cells. Researchers are interested in combining the drug with a small amount of radioactive material to allow prostate cancer lesions to appear more clearly on imaging scans. Researchers are also interested in determining whether …

  • 36 views
  • 08 Nov, 2020
  • 1 location
Anti-EGFR Therapy With IMRT Concurrent Chemoradiotherapy in Locally Advanced OPC With Induced Chemotherapy Resistance

This study is a prospective phase II trial which is designed to evaluate the efficacy and safety of IMRT combined with concurrent chemotherapy and anti-EGFR monoclonal antibody in locally advanced oropharyngeal carcinoma (OPC) with induced chemotherapy resistance. Eligibility criteria include histologically confirmed locally advanced OPC according to the American Joint …

monoclonal antibodies
cancer
induction chemotherapy
measurable disease
chemoradiotherapy
  • 0 views
  • 24 Jan, 2021
  • 1 location
N-Acetylcysteine in Biliary Atresia After Kasai Portoenterostomy

Biliary atresia (BA) is a devastating liver disease of infancy, characterized by bile duct obstruction leading to liver fibrosis, cirrhosis, and eventual need for transplantation in most cases. BA is treated with Kasai portoenterostomy (KP). KPs can achieve bile drainage and improve outcomes. However, even with standard evidence of "good …

  • 1 views
  • 18 Jan, 2021
  • 1 location
Iron Balance Study of Deferasirox Deferoxamine and the Combination of Both

Subjects with thalassemia major require regular transfusion therapy to sustain life. The iron present in the transfused blood remains in the body where it can cause a variety of organ dysfunctions. Lifelong iron chelation therapy is needed to maintain iron balance but its effectiveness varies greatly. Like that of deferoxamine …

desferal
diabetes
serum ferritin level
chelation therapy
iron overload
  • 28 views
  • 07 Nov, 2020
  • 1 location
TheraSphere & Treatment of Unresectable Primary or Unresectable Secondary Liver Cancer

Protocol Synopsis Title A Humanitarian Device Exemption Use Protocol of TheraSphere For Treatment of Unresectable Primary or Secondary Liver Neoplasia Supplier BTG International Canada Inc. Type of Clinical Use Post-Marketing: TheraSphere commercially distributed under HDE # 980006 Objectives Provide supervised access to TheraSphere therapy at this institution Evaluate response to …

  • 0 views
  • 23 Jan, 2021
  • 1 location
Adjunctive Corticosteroids for Tuberculous Meningitis in HIV-infected Adults (The ACT HIV Trial)

The investigators will conduct a randomized, double blind, placebo controlled trial of adjunctive dexamethasone in the initial (6-8 weeks) treatment of tuberculous meningitis in Vietnamese adults. The trial will address a primary hypothesis in all enrolled patients, and a secondary hypothesis in a sub-group of enrolled patients who develop anti-tuberculosis …

tb chemotherapy
rifampin
HIV Vaccine
tuberculosis
isoniazid
  • 76 views
  • 25 Jan, 2021
  • 6 locations
Leukotriene A4 Hydrolase Stratified Trial of Adjunctive Corticosteroids for HIV-uninfected Adults With Tuberculous Meningitis

The primary objective is to determine whether Leukotriene A4 hydrolase (LTA4H) genotype, defined at randomisation, determines dexamethasone's clinical effectiveness when added to the first 6-8 weeks of anti-tuberculosis treatment of TBM. The investigators will conduct a LTA4H genotype stratified, parallel group, randomised, double blind, placebo-controlled multi-centre Phase III non-inferiority trial …

tb chemotherapy
tuberculosis treatment
rifampin
isoniazid
corticosteroids
  • 53 views
  • 25 Jan, 2021
  • 3 locations