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Found 35 clinical trials
A Study of ALRN-6924 for the Prevention of Chemotherapy-induced Side Effects (Chemoprotection)

prevention of chemotherapy-induced side effects in patients with p53-mutated ED SCLC undergoing 2nd-line treatment with topotecan. (Part 1 has completed enrollment). Part 2 NSCLC is a randomized

platinum-based chemotherapy
pemetrexed
kidney function test
carboplatin
TP53
  • 4 views
  • 29 May, 2022
  • 8 locations
A Study of Combination Chemotherapy for Patients With Newly Diagnosed DAWT and Relapsed FHWT

(ifosfamide, carboplatin, etoposide, cyclophosphamide, and topotecan) work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them

  • 0 views
  • 30 May, 2022
  • 92 locations
Tisotumab Vedotin vs Chemotherapy in Recurrent or Metastatic Cervical Cancer (innovaTV 301)

vedotin. Participants in the other group will get one of five different chemotherapy drugs (topotecan, vinorelbine, gemcitabine, pemetrexed, or irinotecan). Participants and their doctors will know which

chemotherapy drugs
pembrolizumab
tisotumab vedotin
bevacizumab
metastatic cervical cancer
  • 3 views
  • 09 Jun, 2022
  • 71 locations
High Risk Neuroblastoma Study 1.8 of SIOP-Europe (SIOPEN)

of induction should receive 2 TVD (Topotecan, Vincristine, Doxorubicin) cycles. After Rapid COJEC induction, localized patients will proceed to consolidation. Patients aged 12-18 months at

monoclonal antibody ch14.18
carboplatin
filgrastim
doxorubicin
mycn protein
  • 308 views
  • 26 Jan, 2021
  • 126 locations
A Study of Mirvetuximab Soravtansine vs. Investigator's Choice of Chemotherapy in Platinum-Resistant, Advanced High-Grade Epithelial Ovarian, Primary Peritoneal, or Fallopian Tube Cancers With High Folate Receptor-Alpha Expression (MIRASOL)

This Phase 3 study is designed to compare the efficacy and safety of mirvetuximab soravtansine vs. investigator's choice chemotherapy in patients with platinum-resistant high-grade epithelial ovarian cancer, primary peritoneal, or fallopian tube cancer, whose tumors express a high-level of FRα. Patients will be, in the opinion of the Investigator, appropriate …

hormonal therapy
serum bilirubin level
cancer
fallopian tube cancer
ovarian epithelial cancer
  • 122 views
  • 27 May, 2022
  • 170 locations
Testing the Addition of 131I-MIBG or Lorlatinib to Intensive Therapy in People With High-Risk Neuroblastoma (NBL)

This phase III trial studies iobenguane I-131 or lorlatinib and standard therapy in treating younger patients with newly-diagnosed high-risk neuroblastoma or ganglioneuroblastoma. Radioactive drugs, such as iobenguane I-131, may carry radiation directly to tumor cells and not harm normal cells. Lorlatinib may stop the growth of tumor cells by blocking …

catecholamines
carboplatin
ganglioneuroblastoma
shortening fraction
doxorubicin
  • 117 views
  • 06 Jun, 2022
  • 95 locations
Cabozantinib With Topotecan-Cyclophosphamide

: Cabozantinib Topotecan Cyclophosphamide The names of the non-investigational supportive care drugs are: Filgrastim, pegfilgrastim, or a related growth

  • 5 views
  • 07 Oct, 2021
  • 2 locations
Topotecan and Melphalan for Retinoblastoma

The purpose of this study is to evaluate topotecan and melphalan for retinoblastoma patients.

  • 0 views
  • 25 Mar, 2021
  • 1 location
Topotecan Plus M6620 (VX-970) vs. Topotecan Alone in People With Relapsed Small-Cell Lung Cancer

treatment if they come back after chemotherapy. Treatment with two drugs combined may be able to help. Objective To compare M6620 plus topotecan to topotecan alone in

topotecan
  • 1 views
  • 18 Nov, 2019
  • 1 location
Durvalumab and Topotecan or Lurbinectedin for the Treatment of Relapsed or Refractory Small Cell Lung Cancer

This phase II trial studies the effects of durvalumab and topotecan or lurbinectedin in treating patients with extensive stage small cell lung cancer that has come back (relapsed) or has not

  • 0 views
  • 30 Apr, 2022
  • 1 location