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Found 31 clinical trials
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AEWS1031: A Phase III Randomized Trial of Adding Vincristine-Topotecan-Cyclophosphamide to Standard Chemotherapy in Initial Treatment of Non-Metastatic Ewing Sarcoma

AEWS1031: A Phase III Randomized Trial of Adding Vincristine-Topotecan-Cyclophosphamide to Standard Chemotherapy in Initial Treatment of Non-Metastatic Ewing Sarcoma

  • 380 views
  • 08 Nov, 2020
  • 1 location
Topotecan Episcleral Plaque for Treatment of Retinoblastoma

This single site, single-arm, non-randomized, dose escalation phase I toxicity clinical trial will assess primarily the safety and secondarily the efficacy of episcleral topotecan in patients

renal function
platelet count
topotecan
intraocular retinoblastoma
  • 118 views
  • 29 May, 2021
  • 1 location
Topotecan Episcleral Plaque for Treatment of Retinoblastoma

This single-arm, non-randomized, dose escalation phase I clinical trial will assess primarily the safety and secondarily the efficacy of episcleral topotecan in patients with active de novo or

renal function
calcium
intraocular retinoblastoma
platelet count
topotecan
  • 0 views
  • 04 Oct, 2022
  • 2 locations
A Study of FF-10850 Topotecan Liposome Injection in Advanced Solid Tumors

To determine the safety profile, maximum tolerated dose (MTD), dose-limiting toxicities (DLTs), and recommended Phase 2 dose (RP2D) of FF-10850 (topotecan liposome injection) in patients with

  • 18 views
  • 29 Apr, 2022
  • 2 locations
Ocular Conservative Treatment for Retinoblastoma : Efficacy of the New Management Strategies and Visual Outcome (RETINO2018)

randomized phase-II study evaluating the efficacy of Intra-Arterial Chemotherapy (IAC) with melphalan and topotecan versus melphalan alone, both in association with ophthalmologic treatments. Study

carboplatin
anesthesia
cancer
systemic chemotherapy
etoposide
  • 0 views
  • 25 Mar, 2022
  • 25 locations
Protocol for the Study and Treatment of Participants With Intraocular Retinoblastoma

intraocular retinoblastoma (Stratum B) to two upfront courses of therapy consisting of subconjunctival carboplatin and systemic topotecan. SECONDARY OBJECTIVES: To

cyclophosphamide
carboplatin
mesna
beam radiation
filgrastim
  • 43 views
  • 07 Oct, 2022
  • 1 location
A Prospective International Multicenter Clinical Trial for Eyes With Relapsed Retinoblastoma

While 95% of patients with retinoblastoma can be cured nowadays, treatment of relapse remains challenging, ending often in enucleation and/or radiotherapy. In the last 10 years, new treatment modalities have been developed to give the chance of cure also in relapse, avoiding enucleation which results in esthetic sequelae and orbital …

cryotherapy
melphalan
topotecan
recurrent retinoblastoma
  • 0 views
  • 11 Dec, 2021
  • 1 location
Treatment Protocol for Non-Metastatic Unilateral Retinoblastoma (RbGALOP2)

This protocol provides guidelines for the management of non-metastatic unilateral retinoblastoma and introduces an innovative adjuvant therapy for higher risk patients based upon the results of the Grupo de America Latina de Oncologia Pediatrica (GALOP) I study. Conservative therapy will be not protocolized.

  • 64 views
  • 01 Mar, 2022
  • 1 location
An International Multicenter Phase II Randomised Trial Evaluating and Comparing Two Intensification Treatment Strategies for Metastatic Neuroblastoma Patients With a Poor Response to Induction Chemotherapy (VERITAS)

The main objective is to evaluate the efficacy of two intensified consolidation strategies in very-high risk neuroblastoma (VHR-NBL) patients in terms of event-free survival from randomisation date. This evaluation will follow a hierarchical testing procedure: each experimental treatment will be first evaluated as a single-arm phase 2 study, and in …

  • 5 views
  • 13 Oct, 2022
  • 3 locations
PHASE 1/2 STUDY TO EVALUATE PALBOCICLIB (IBRANCE®) IN COMBINATION WITH IRINOTECAN AND TEMOZOLOMIDE OR IN COMBINATION WITH TOPOTECAN AND CYCLOPHOSPHAMIDE IN PEDIATRIC PATIENTS WITH RECURRENT OR REFRACTORY SOLID TUMORS

A study to learn about safety and find out maximum tolerable dose of palbociclib given in combination with chemotherapy (temozolomide with irinotecan or topotecan with cyclophosphamide) in

medulloblastoma
cyclophosphamide
measurable disease
neutrophil count
renal function
  • 129 views
  • 19 Oct, 2022
  • 81 locations