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Found 31 clinical trials
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AEWS1031: A Phase III Randomized Trial of Adding Vincristine-Topotecan-Cyclophosphamide to Standard Chemotherapy in Initial Treatment of Non-Metastatic Ewing Sarcoma

AEWS1031: A Phase III Randomized Trial of Adding Vincristine-Topotecan-Cyclophosphamide to Standard Chemotherapy in Initial Treatment of Non-Metastatic Ewing Sarcoma

  • 376 views
  • 08 Nov, 2020
  • 1 location
Combination Chemotherapy in Treating Young Patients With Nonmetastatic Rhabdomyosarcoma

RATIONALE: Drugs used in chemotherapy work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Giving more than one drug (combination chemotherapy) may kill more tumor cells. It is not yet known which combination chemotherapy regimen is more …

vinorelbine
carboplatin
cancer chemotherapy
dactinomycin
conventional surgery
  • 103 views
  • 07 Nov, 2020
  • 9 locations
Observation Combination Chemotherapy Radiation Therapy and/or Autologous Stem Cell Transplant in Treating Young Patients With Neuroblastoma

RATIONALE: Drugs used in chemotherapy work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Giving combination chemotherapy may kill more tumor cells. Radiation therapy uses high-energy x-rays to kill tumor cells. An autologous stem cell transplant may …

carboplatin
cyclophosphamide
vindesine
isotretinoin
conventional surgery
  • 30 views
  • 07 Nov, 2020
  • 28 locations
Topotecan Episcleral Plaque for Treatment of Retinoblastoma

This single site, single-arm, non-randomized, dose escalation phase I toxicity clinical trial will assess primarily the safety and secondarily the efficacy of episcleral topotecan in patients

intraocular retinoblastoma
platelet count
renal function
topotecan
  • 2 views
  • 24 Jan, 2021
  • 1 location
Study in Patients With SCLC of Veliparib in Combination With Topotecan

Phase I/II Study in Patients With Small Cell Lung Cancer (SCLC) of Veliparib in Combination With Topotecan

topotecan
  • 53 views
  • 03 Feb, 2021
  • 3 locations
A Study of FF-10850 Topotecan Liposome Injection in Advanced Solid Tumors

To determine the safety profile, maximum tolerated dose (MTD), dose-limiting toxicities (DLTs), and recommended Phase 2 dose (RP2D) of FF-10850 (topotecan liposome injection) in patients with

  • 0 views
  • 25 Jan, 2021
  • 3 locations
Protocol for the Study and Treatment of Participants With Intraocular Retinoblastoma

intraocular retinoblastoma (Stratum B) to two upfront courses of therapy consisting of subconjunctival carboplatin and systemic topotecan. SECONDARY OBJECTIVES: To

mesna
intraocular retinoblastoma
nervous
carboplatin
unilateral retinoblastoma
  • 43 views
  • 04 Feb, 2021
  • 1 location
A Phase I/II Study of Paclitaxel Plus Carboplatin Plus Vorinostat in Recurrent Ovarian Cancer

consists of systemic chemotherapy using either carboplatin plus paclitaxel (in platinum-sensitive patients) or single agent chemotherapy with agents like liposomal doxorubicin, topotecan, weekly

carboplatin
platinum-sensitive ovarian carcinoma
neutrophil count
gemcitabine
recurrent ovarian cancer
  • 10 views
  • 07 Nov, 2020
  • 1 location
Treatment Protocol for Non-Metastatic Unilateral Retinoblastoma

This protocol provides guidelines for the management of non-metastatic unilateral retinoblastoma and introduces an innovative adjuvant therapy for higher risk patients based upon the results of the Grupo de America Latina de Oncologia Pediatrica (GALOP) I study. Conservative therapy will be not protocolized.

  • 48 views
  • 23 Jan, 2021
  • 1 location
Activity Study of Bevacizumab With Temozolomide Irinotecan for Neuroblastoma in Children

The purpose of this study is to investigate whether Bevacizumab (an anti-VEGF monoclonal antibody) added to a backbone chemotherapy regimen (Temozolomide, Irinotecan-Temozolomide or Topotecan

monoclonal antibodies
high-risk neuroblastoma
dyspnea at rest
granulocyte colony stimulating factor
pulse oximetry
  • 57 views
  • 24 Jan, 2021
  • 10 locations