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Found 57 clinical trials
The Effects of Whole-body Vibration on Increasing Quadriceps Strength in Patients With ACL Ruptures

Introduction: Approximately 35% patients can not return to sports after anterior cruciate ligament reconstruction(ACLR). Persistent quadriceps weakness is a factor that prevents patients return to sports. Pre-operative quadriceps strength is a predictor for the outcomes after ACLR. Therefore, enhancing pre-operative quadriceps is important. However, current prehabilitation can not well restore …

lower extremity injury
acl injuries
overuse syndromes
  • 15 Aug, 2021
  • 1 location
Noradrenergic Activity and Attention

activity during aging influences attentional control. In the current study, tonic noradrenergic activity will be increased or decreased to investigate its behavioral and neural effects on attentional

Accepts healthy volunteers
  • 24 Nov, 2021
  • 1 location
Creation of a Register of Patients With Neonatal-onset Epileptic Encephalopathy

epilepsy that begins in the first days after birth, seizures that result in tonic muscle spasms that last from 1 to 10 seconds, and an interictal EEG called "suppression-burst". "That is, paroxysmal

  • 27 Mar, 2021
  • 14 locations
Familial Aggregation and Biomarkers in REM Sleep Behaviour Disorder.

In this cohort study, the investigators aim to study the familial aggregation of REM sleep behavior disorder (RBD) and compare the differences in major biomarkers of neurodegeneration, including percentage of EMG activity during REM sleep, cognitive functions, autonomic dysfunction, and psychiatric disorders, between unaffected first degree relatives of RBD cases …

psychiatric disorder
Accepts healthy volunteers
  • 13 Feb, 2022
  • 1 location
What is the Nature of Pelvic Floor Muscle Involvement in Dyspareunia?

Dyspareunia, or pain experienced by women during penetrative sexual activities, affects the psychological and sexual health of more than one in five Canadian women [1], yet its pathophysiology is poorly understood [2-4] and evidence for management approaches is limited.[5] It is thought that pelvic floor muscle (PFM) dysfunction is implicated …

Accepts healthy volunteers
  • 07 Oct, 2021
  • 1 location
Molecular and Cellular Characterization of Cardiac Tissue in Postnatal Development

The study team will use small pieces of human hearts which are removed as part of a required surgical procedure to study different objectives. One of the objective is how calcium ions pass through the membrane of heart cells in order to tell the heart cell how much force to …

cardiopulmonary bypass
heart disease
  • 30 Jun, 2022
  • 1 location
Rare Disease Patient Registry & Natural History Study - Coordination of Rare Diseases at Sanford (CoRDS)

CoRDS, or the Coordination of Rare Diseases at Sanford, is based at Sanford Research in Sioux Falls, South Dakota. It provides researchers with a centralized, international patient registry for all rare diseases. This program allows patients and researchers to connect as easily as possible to help advance treatments and cures …

rare diseases
other disease
  • 25 Jan, 2022
  • 2 locations
Prevalence Determinants and Natural History of Frailty and Pre-frailty in Elderly People

Frailty syndrome (i.e. frailty) is a geriatric syndrome which relies on the reduction of multisystem reserve capacity. Frail people have a lower potential to respond to external stressors and various life incidents as well as they present a weak prognosis particularly in cardiovascular diseases. Yet, frailty is not only a …

cardiovascular disease
frailty syndrome
  • 25 Jan, 2021
  • 1 location
A Study to Evaluate the Effectiveness of Perampanel as Only Add-on Treatment in Participants With Primary or Secondarily Generalized Tonic-clonic Seizures

tonic-clonic (PGTC) or secondarily generalized tonic-clonic (SGTC) seizures based on focal or idiopathic generalized epilepsy in a non-interventional (observational) setting.

clonic seizure
  • 25 Feb, 2022
  • 21 locations
Cardiac MRI for Detection of Acute and Chronic Cardiac Involvement in Patients With Epilepsy

part of the study: In the acute setting, cardiac MRI will be performed in patients before and after a tonic-clonic seizure and compared intraindividually. In this study arm, potential

cardiac mri
  • 21 Sep, 2021
  • 1 location