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Found 57 clinical trials
Comparing Long-term Effectiveness of High Frequency and Burst Spinal Cord Stimulation

Over 100 million Americans suffer from chronic pain resulting in annual cost of roughly $635 billion. Limited treatments are available for this widespread disease. The data supporting these treatments lack generalizability to patients with more serious medical and psychological comorbidities who are often excluded from explanatory efficacy trials. This study …

  • 14 May, 2022
  • 1 location
Pioglitazone to Reduce Sympathetic Overactivity in CKD Patients

Chronic kidney disease (CKD) is associated with a higher risk of cardiovascular disease and death. An overactive sympathetic nervous system in CKD patients is one of the major mechanisms increasing the cardiovascular risks in this patient population. Recently, some studies have shown that a drug typically used to improve glucose …

cardiovascular disease
glomerular filtration rate
  • 03 Jun, 2022
  • 2 locations
Immune Induction Strategies to Improve Response to Immune Checkpoint Blockade in Triple Negative Breast Cancer (TNBC) Patients (TONIC-2)

This is a single center non-blinded randomized multi-cohort non-comparative phase II trial with a Simon's two-stage design.

brain metastases
triple negative breast cancer
breast cancer
  • 09 Apr, 2022
  • 1 location
Cognitive Stimulation for Elderly Bipolar Patients (TONIC)

Age is a major risk factor for the development of cognitive disorders and neurodegenerative pathologies. Cognitive disorders during the phases of bipolar disease are known to exist, and alterations increase significantly after the age of 65. Drug treatments seem to have only a limited effect. A cognitive stimulation program has …

neurodegenerative disorders
cognitive impairment
cognitive stimulation
cognitive disorder
  • 23 Mar, 2022
  • 1 location
The Role of Natural Killer, Complement and T-lymphocytes in COVID-19 Disease, a Prospective Monocentric Study (TONIC)

The current study is an open, non-randomized, monocentric, and interventional study. CoViD-19 patients will be recruited at UZ Brussel after informed consent is obtained. Whole blood and serum samples will be collected during acute disease (inclusion and 7 days after inclusion) and during patient follow-up at 2 months after infection. …

Accepts healthy volunteers
  • 12 Mar, 2022
  • 1 location
Familial Risk for Bipolar Disorder and Alcohol Sensitivity

Early identification in individuals with bipolar disorder who are at risk for AUDs could inform novel intervention strategies and improve life-long outcomes. The primary objective of this protocol is to use alcohol administration procedures and alcohol biosensor technology to investigate responses to alcohol, compared to placebo, and relationship with parental …

alcohol use disorder
  • 11 Jun, 2021
  • 1 location
Biomarkers for Prediction of Analgesic Efficacy in Knee OA.

With high NNTs for indiscriminative use in chronic pain, treatment unavoidably entails frustrating long trial and errors. It is timely to identify biomarkers that can predict analgesic efficacy for the individual patient. The investigators propose a framework of interrelations between patient's pain modulation profile (PMP) and the drug's mode of …

chronic pain
  • 11 Mar, 2022
  • 1 location
Post-stroke Epilepsy: Primary Prophylaxis Study

Advance in stroke treatment have resulted in a dramatic reduction in the stroke mortality, however, the number of stroke survivors living with morbidity has increased significantly. As we know, post-stroke epilepsy has been identified as a significant clinical issue in stroke survivors and stroke is the most common cause of …

  • 08 May, 2021
  • 1 location
Adjunct Treatment With Cariprazine for Adults With Attention-deficit/Hyperactivity Disorder

According to the Canadian ADHD Practice Guidelines, psychostimulants are the preferred treatment of attention-deficit/hyperactivity disorder (ADHD), especially for those that require urgent care. Specifically, long-acting psychostimulants are considered the gold-standard pharmacological treatment for ADHD. Using extended-release formulations, long-acting psychostimulants provide an extended duration of daily symptom relief in addition to …

  • 19 Dec, 2021
  • 1 location
Fine Motor Skills and Post-Stroke Swallowing (MOFIDA)

Swallowing disorders are a common consequence of stroke. After stroke, some patients retain a dysphagia responsible for an alteration of the quality of life, respiratory diseases and a degradation of the general health status. The oral phase of the swallowing involves a significant control of the various intraoral organs. These …

  • 02 May, 2022
  • 1 location