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Found 58 clinical trials
SCS Stimulation Clamp to Assess Impact of Stimulation on Glucose Metabolism

mechanosensitive Aβ fibers suppresses the transmission of pain stimuli via the pain-sensitive C fibers to the brain in the spinal cord. Conventional SCS consists of periodically emitted tonic stimuli with a

  • 0 views
  • 25 Apr, 2022
Adjunctive Transcranial Stimulation to Reduce Impulsivity in Opiate Use Disorder

craving for cigarettes as well as opioids. Participants will perform a stress induction procedure that mirrors an optimum combination of cues that trigger tonic craving in their environment while exposed

nicotine product
opioid
drug use
opioid use disorder
opioid use
  • 0 views
  • 28 Oct, 2021
  • 1 location
Mature Vinegar Prophylaxis Against Recurrent Calcium Oxalate Nephrolithiasis

tonic which may lower blood pressure and cholesterol level. Our national epidemiological data in China showed that consumed more mature vinegar was associated with decreased risk of kidney stones

ct scan
oxalate
urolithiasis
Accepts healthy volunteers
Uric Acid Test
  • 0 views
  • 25 Feb, 2022
  • 1 location
An Inflammatory Challenge Using Endotoxin

normalization of cytokine levels within hours. This "phasic" inflammation is distinct from chronic ("tonic") levels of inflammation that may be present with AUD. A total of 38 non-treatment seeking heavy

Accepts healthy volunteers
  • 0 views
  • 29 Oct, 2021
  • 1 location
Treatment of Chronic Cluster Headache With TENS and ONS

(deactivated ONS system). Clinical follow-up visit by the end of month seven. Months 8-10: Open label period. All participants will receive tonic (conventional, paresthesia-inducing) ONS.

paresthesia
headache
anxiety
depression
  • 0 views
  • 27 Sep, 2021
  • 1 location
Burst Crossover Trial

complex programming to deliver high-frequency stimuli. This SCS technique seems to provide paresthesia-free stimulation, resulting in better pain relief of low back and leg pain then traditional tonic

paresthesia
leg pain
pain relief
back surgery
spinal cord
  • 0 views
  • 07 Jun, 2022
  • 1 location
Mitochondrial-targeted Antioxidant Supplementation for Improving Age-related Vascular Dysfunction in Humans

endothelial function with MitoQ was mediated by reduced endothelial cell mtROS production, associated reductions in tonic mtROS-related suppression of EDD, and improved mitochondrial health, linked in part to

  • 0 views
  • 03 May, 2021
  • 1 location
Locus-coeruleus Function in Normal Elderly and AD Risk (LEAD)

Growing evidence suggests that Alzheimer's disease (AD) pathological changes begin decades before clinical symptoms and tau abnormalities in the locus coeruleus (LC) can be observed since midlife. We have previously demonstrated functional vulnerability of the LC to aging and stress, as well as an association between higher CSF tau and …

Accepts healthy volunteers
polysomnography
alzheimer's disease
  • 0 views
  • 10 Mar, 2022
  • 1 location
Burst Spinal Cord Stimulation for Neuropathic Pain.

This study will evaluate the effect of Burst spinal cord stimulation (SCS) in the treatment of painful radiculopathy in lower extremity(ies) with or without lower back pain. It is a multicenter double-blinded "n-of-1" RCT with repeated two-week periods of Burst SCS or sham in randomised order.

peripheral neuropathic pain
back pain
radiculopathy
spinal cord
  • 0 views
  • 25 Feb, 2022
  • 2 locations
Pre-operative Trial for Breast Cancer With Nivolumab in Combination With Novel IO (BELLINI)

To determine whether short-term pre-operative nivolumab either as monotherapy or in combination with low dose doxorubicin or novel IO combinations can induce immune activation in early BC.

erbb2
ki-67
HER2
breast cancer staging
doxorubicin
  • 1 views
  • 23 Apr, 2022
  • 1 location