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Found 8 clinical trials
Safety of Lixivaptan in Subjects Previously Treated With Tolvaptan for Autosomal Dominant Polycystic Kidney Disease

treated with tolvaptan and were permanently discontinued from the drug for that reason. Up to 50 eligible subjects will be enrolled and treated with lixivaptan for 52 weeks following titration to an

chronic kidney disease
body mass index
renal disease
hypertension
tolvaptan
  • 0 views
  • 28 Mar, 2021
  • 9 locations
Tolvaptan-Octreotide LAR Combination in ADPKD

levels to wild type levels. The vasopressin antagonist Tolvaptan and the somatostatin analogue Octreotide share a similar renoprotective effect also in human disease. Both medications

tubular
octreotide
somatostatin
vasopressin antagonists
renal disease
  • 2 views
  • 25 Jan, 2021
  • 2 locations
Outcome and Treatment Quality Study of Tolvaptan to Treat Hyponatremia in Patients With Heart Failure.

The objective is to evaluate the efficacy and safety on the tolvaptan for increasing serum Na levels in patients with worsening heart failure and hyponatremia.

  • 10 views
  • 07 Nov, 2020
  • 1 location
HEAL STUDY (Hepatic Encephalopathy and Albumin Study)

Patients with continued cognitive impairment after episodes of HE have few options beyond lactulose and rifaximin in the US. Therefore using IV albumin in a randomized, double-blind, placebo-controlled trial, which could beneficially impact inflammation, could be an additional approach to improve cognition. This 6 week trial will study changes in …

liver disease
flicker
lactulose
ast/alt ratio
varices
  • 66 views
  • 25 Jan, 2021
  • 1 location
Post-Marketing Surveillance Study of Tolvaptan in Patients With ADPKD

The purpose of this study is to evaluate the safety and effectiveness of tolvaptan in patients with autosomal dominant polycystic kidney disease (ADPKD) in the real world clinical setting in

renal disease
tolvaptan
  • 0 views
  • 06 Mar, 2021
  • 1 location
Samsca Post-marketing General Drug Use-results Survey in Patients With Hyponatremia in SIADH

The purpose of this study is to confirm the safety of tolvaptan in patients with hyponatremia in syndrome of inappropriate antidiuretic hormone secretion (SIADH) in Japan

  • 0 views
  • 08 Apr, 2021
  • 1 location
The German ADPKD Tolvaptan Treatment Registry

The German ADPKD Tolvaptan Treatment Registry is a prospective, observational, multicentric study of patients suffering from ADPKD that are considered for tolvaptan treatment. All ADPKD patients

  • 23 views
  • 15 Feb, 2021
  • 12 locations
Canadian Medical Assessment of JINARC Outcomes Registry

This study is part of the Health Canada approval requirement for tolvaptan and is an observational, non-interventional study (NIS) describing the impact of tolvaptan on ADPKD-related burden of

  • 3392 views
  • 27 Jan, 2021
  • 19 locations