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Found 138 clinical trials
Biomarkers of Increased Free Living Sleep Time

This protocol will increase sleep duration in participants who maintain less than 6 hours sleep per night, to target the recommended 7 hours of sleep per night. The focus of this study is determine how increasing nightly sleep duration in these individuals who maintain less than 6 hours sleep per …

insulin
body mass index
hypersomnia
  • 25 views
  • 10 Jul, 2021
  • 2 locations
Effect of Novel Glucagon Receptor Antagonist REMD-477 on Glucose and Adipocyte Metabolism in T2DM

With REMD's glucagon receptor antagonist, the study team propose to provide a comprehensive examination of the effect of elevated plasma glucagon concentrations in Type 2 Diabetes Mellitus (T2D) patients on: (i) glucose tolerance; (ii) insulin sensitivity in liver, muscle, and adipocytes; (iii) beta cell function; (iv) adipocyte inflammation.

metformin
insulin
hemoglobin a1c
glucagon
antidiabetic agents
  • 0 views
  • 29 Dec, 2021
  • 1 location
Phenotyping Genetic Risk for Type 2 Diabetes

This study tests the hypothesis that non-diabetic individuals with a high genetic risk score for type 2 diabetes have impaired glucose tolerance and insulin resistance compared to those with a low genetic risk score for type 2 diabetes.

insulin resistance
impaired glucose tolerance
Accepts healthy volunteers
  • 12 views
  • 22 Mar, 2022
  • 1 location
Effect of Whole Fruit on Glycemic Control in Adults With Type 2 Diabetes

Diabetes costs the U.S. healthcare system more than any other disease, and nearly half of Americans will develop either diabetes or prediabetes in their lifetime. It is therefore critical to find new strategies to treat or reverse diabetes. One such approach is adopting a healthy diet, which can dramatically improve …

  • 0 views
  • 11 Dec, 2021
  • 1 location
Effect of Weight Loss on Body Composition and Metabolic Function in Women With Lipedema (Lipedema)

Lipedema is a disorder characterized by massive, bilateral accumulation of fat below the waist and in the legs. Enlargement of the lower extremities is often accompanied by leg pain and accumulation of fluid. Little is known about the functional changes that lead to fat accumulation and pain in women with …

Accepts healthy volunteers
  • 331 views
  • 09 Apr, 2022
  • 1 location
The Exercise And Colorectal Cancer Treatment Trial (EXACT)

This study will examine the biologic processes through which exercise may prevent disease recurrence in patients who have completed treatment for colorectal cancer.

aerobic exercise
stage iii colon cancer
  • 0 views
  • 24 Mar, 2022
  • 1 location
Role of Sweetness in Glucose Regulation (STS)

Data from several studies show that consuming a diet high in low-calorie sweeteners (LCS), mainly in diet sodas, is linked to the same metabolic disorders as consuming a diet high in added sugars, including an increased risk of developing type 2 diabetes. Sweet taste receptors, once thought to be unique …

sugars
type 2 diabetes mellitus
insulin
diabetes
Accepts healthy volunteers
  • 144 views
  • 07 Feb, 2022
  • 1 location
Bisphenol A and Muscle Insulin Sensitivity

This study examine oral bisphenol A consumption on muscle insulin sensitivity and hepatic glucose suppression. Half of the participants will receive a diet plus BPA and the other half will receive a diet plus no bisphenol A.

Accepts healthy volunteers
  • 0 views
  • 17 Feb, 2022
  • 1 location
Autologous Mesenchymal Stromal Cells and Islet Co-transplantation in TP-IAT

This is a clinical trial for non-diabetic chronic pancreatitis (CP) patients undergoing total pancreatectomy with islet autotransplantation (TP-IAT). Participants will be randomized to either bone marrow-derived mesenchymal stem cells (MSCs) or control with the standard of care. Participants will be followed for one-year post-transplant.

  • 0 views
  • 14 Apr, 2022
  • 1 location
Breakfast, Exercise and Metabolic Health in Healthy Women

This project aims to investigate the impact of acute bout of submaximal exercise under different pre-exercise dietary conditions (fasted state versus high carbohydrate breakfast versus high protein breakfast) on postprandial glycaemic, appetite regulation and energy balance in active healthy women.

Accepts healthy volunteers
  • 0 views
  • 21 Apr, 2022
  • 1 location