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Found 6 clinical trials
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Study to Assess the Safety Tolerability and Efficacy of Tipifarnib Plus Bortezomib in the Treatment of Acute Myeloid Leukemia

This is one of the first studies of combination of Zarnestra plus Velcade in man. A primary objective of the study is therefore to assess the safety and tolerability of multiple doses of Zarnestra plus Velcade in patients with AML. New treatments for patients that are untreatable with intensive chemotherapy …

  • 12 views
  • 07 Nov, 2020
  • 1 location
None
Safety and Efficacy of Tipifarnib in Head and Neck Cancer With HRAS Mutations and Impact of HRAS on Response to Therapy

An international, multicenter, open-label, 2 cohort, non-comparative, pivotal study evaluating the efficacy of tipifarnib in HRAS mutant HNSCC (AIM-HN). The first cohort will assess the

measurable disease
HRAS
neck cancer
head and neck cancer
caries
  • 3 views
  • 08 Mar, 2021
  • 138 locations
None
Targeted Therapy Directed by Genetic Testing in Treating Pediatric Patients With Relapsed or Refractory Advanced Solid Tumors Non-Hodgkin Lymphomas or Histiocytic Disorders (The Pediatric MATCH Screening Trial)

This Pediatric MATCH screening and multi-sub-study phase II trial studies how well treatment that is directed by genetic testing works in pediatric patients with solid tumors, non-Hodgkin lymphomas, or histiocytic disorders that have progressed following at least one line of standard systemic therapy and/or for which no standard treatment exists …

hodgkin's disease
cns neoplasm
blood transfusion
radiopharmaceutical therapy
solid tumor
  • 997 views
  • 24 Oct, 2021
  • 114 locations
None
Tipifarnib in Advanced Squamous NSCLC With Oncogen HRAS MutAtionS

for SQ-NSCLC. The treatment phase will investigate the antitumor activity in terms of ORR of tipifarnib in subjects with locally advanced squamous non-small cell lung cancer (SQ-NSCLC) with

metastasis
measurable disease
HRAS
kidney function test
squamous non-small cell lung cancer
  • 14 views
  • 29 Sep, 2021
  • 35 locations
None
Tipifarnib for the Treatment of Advanced Solid Tumors Lymphoma or Histiocytic Disorders With HRAS Gene Alterations a Pediatric MATCH Treatment Trial

This phase II pediatric MATCH trial studies how well tipifarnib works in treating patients with solid tumors that have recurred or spread to other places in the body (advanced), lymphoma, or

nervous system disorder
nervous system disorders
blood transfusion
radiopharmaceutical therapy
solid tumor
  • 20 views
  • 20 Oct, 2021
  • 88 locations
None
A Phase I Single Center Open-label Clinical Pharmacology Study to Evaluate the Effect of Tipifarnib on Cardiac Safety in Subjects With Advanced Solid Malignancies

A Phase I, single center, open-label clinical pharmacology study designed to evaluate the effect of tipifarnib on cardiac repolarization (corrected QT interval [QTc] duration) following a single

  • 0 views
  • 24 May, 2021
  • 2 locations