Found 21 clinical trials
TSH Suppression During Radiotherapy on Thyroid Site to Prevent Iatrogenic Hypothyroidism in Pediatric Cancer Patients (WIN-HYPO2021)
To offer the possibility of a treatment that could achieve a meaningful reduction in the incidence of post-radiation therapy hypothyroidism. Thyroid dysfunction may develop from a few months to several years after patients have completed their radiation treatment. In children with chronic diseases, or given lengthy anti-neoplastic treatments, recurrent or …
- 0 views
- 23 Apr, 2022
- 1 location
Gastrografin for Treating Small Bowel Obstruction in Children
This is a multi-centre clustered open label clinical trial testing the effectiveness of adding Gastrografin to standard non-surgical management of small bowel obstruction. Gastrografin is a radiopaque contract agent that exhibits a mild laxative effective due to its high osmolarity and ability to pull water into the intestines and bowels …
- 15 views
- 22 Apr, 2022
- 1 location
Rec-LH PD and Safety Profile in Hypogonadotropic Hypogonadism Men (RHYTHM)
Objectives The overall clinical question is whether LH supplementation to men in indication for FSH according to the AIFA note 74, or with HH, will improve spermatogenesis and pregnancy rate (spontaneous or after ART) over FSH alone or FSH+hCG. However, since LH has never been used in men so far, …
- 0 views
- 05 Mar, 2022
Intravenous Thyroxine for Heart-Eligible Organ Donors
This randomized controlled trial will evaluate whether intravenous thyroxine infusion given to brain-dead organ donors who are eligible to donate hearts for 12 hours will result in more hearts
- 0 views
- 08 Dec, 2021
- 14 locations
The Effect of Tafamidis on Transthyretin Stabilization Safety Tolerability and Efficacy in Transthyretin Amyloid Polyneuropathy Patients
stabilizer of both variant and wild-type TTR. Tafamidis binds to TTR at the thyroxine binding sites and inhibits TTR tetramer dissociation, the rate limiting step in the amyloidogenic process. The result
- 0 views
- 23 Jul, 2021
- 1 location
Fiber Intervention on Gut Microbiota in Children With Prader-Willi Syndrome
Prader-Willi syndrome (PWS) is the most common syndromic cause of obesity. Individuals with PWS characteristically experience excessive weight gain and severe hyperphagia with food compulsivity in early childhood, which often leads to the onset of obesity and metabolic complications. The pathogenesis of hyperphagia and progressive weight gain in PWS is …
- 0 views
- 22 Apr, 2022
- 1 location
Treatment of Graves´Ophthalmopathy With Simvastatin (GO-DS)
In an investigator initiated multicenter trial (Malm, Odense, rhus) the investigators aim at evaluating activity of Gravesophthalmopathy (GO) and progress to severe GO in patients with mild to moderate Graves ophthalmopathy treated with simvastatin or no treatment.
- 53 views
- 27 Feb, 2022
- 1 location
The Effect of Preoperative Oral Dexamethasone Supplementation on the Outcome of Thyroidectomised Patients. (Dexa)
Glucocorticoids are well known for their analgesic, anti-inflammatory, immunomodulatory and anti-emetic effects. Recovery time after thyroid surgery may depend on several factors, such as postoperative pain, nausea and vomiting, postoperative sore throat, voice disorders and symptomatic hypocalcaemia (low serum calcium level). However, there is little information in the literature about …
- 0 views
- 24 Mar, 2022
- 1 location
A Phase 2 Open-Label Study to Evaluate the Efficacy and Safety of Ruxolitinib on Hair Regrowth in Patients With Autoimmune Polyendocrinopathy Candidiasis Ectodermal Dystrophy (APECED)-Associated Alopecia Areata
Background Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy (APECED) is a problem of the immune system. In people with APECED, the immune system makes a mistake and attacks the body. Some people with APECED have a type of hair loss called alopecia areata (AA). No drugs are approved to treat AA. Objective …
- 30 views
- 25 Oct, 2022
- 1 location
Personalized Treatment Planning for Radio-iodine Therapy of Thyroid Disease
The Collar Therapy Indicator (CoTI) (A device that is placed in collar around the neck resembling a turtle neck sweater collar with a wire and recording box) has been shown in a single small previously published experience to provide data regarding radioiodine exposure that correlates with conventional methods of measuring …
- 363 views
- 29 Oct, 2022
- 1 location