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Found 192 clinical trials
Molecular Analysis for Therapy Choice (MATCH)

This phase II MATCH trial studies how well treatment that is directed by genetic testing works in patients with solid tumors or lymphomas that have progressed following at least one line of standard treatment or for which no agreed upon treatment approach exists. Genetic tests look at the unique genetic …

other malignancy
fgfr inhibitor azd4547
cancer
total bilirubin
targeted therapy
  • 6595 views
  • 20 Oct, 2022
  • 906 locations
An Open-Label, Multicenter, Global Phase 2 Basket Study of Entrectinib for the Treatment of Patients With Locally Advanced or Metastatic Solid Tumors That Harbor NTRK1/2/3, ROS1, or ALK Gene Rearrangements (STARTRK-2)

This is an open-label, multicenter, global Phase 2 basket study of entrectinib (RXDX-101) for the treatment of patients with solid tumors that harbor an NTRK1/2/3, ROS1, or ALK gene fusion. Patients will be assigned to different baskets according to tumor type and gene fusion.

gene fusion
targeted therapy
proto-oncogene tyrosine-protein kinase ros
cancer chemotherapy
small molecule
  • 16 views
  • 25 Oct, 2022
  • 9 locations
DART: Dual Anti-CTLA-4 and Anti-PD-1 Blockade in Rare Tumors

This phase II trial studies nivolumab and ipilimumab in treating patients with rare tumors. Immunotherapy with monoclonal antibodies, such as nivolumab and ipilimumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. This trial enrolls participants for …

other malignancy
beta-hcg
cancer
total bilirubin
immunosuppression
  • 6651 views
  • 22 Oct, 2022
  • 752 locations
Study of SO-C101 and SO-C101 in Combination With Pembro in Adult Patients With Advanced/Metastatic Solid Tumors

A multicenter open-label phase 1/1b study to evaluate the safety and preliminary efficacy of SO-C101 as monotherapy and in combination with pembrolizumab in patients with selected advanced/metastatic solid tumors

measurable disease
chemotherapy regimen
biological factors
cancer chemotherapy
neuropathy
  • 43 views
  • 30 Apr, 2022
  • 7 locations
18F-DOPA II - PET Imaging Optimization

A single centre non-randomized, non-blinded phase III prospective cohort study of 18F-DOPA PET/CT imaging in specific patient populations: Pediatric patients (less than 18 years old) with congenital hyperinsulinism. Pediatric patients (less than 18 years old) with neuroblastoma. Pediatric (less than 18 years old) or Adult patients (18 or older) with …

dementia
parkinson's disease
dopa
  • 8 views
  • 03 May, 2022
  • 1 location
Hereditary Risk Factors for Thyroid Cancer

Thyroid cancers can occur sporadically, but can also be found as tumors that cluster in families with other cancers or genetic syndromes. Researchers are studying thyroid cancer in children and

Accepts healthy volunteers
cancer
thyroid nodule
  • 10 views
  • 16 May, 2022
  • 1 location
PDR001 Combination Therapy for Radioiodine-Refractory Thyroid Cancer

The purpose of this study is to find out whether a drug called PDR001, combined with either trametinib or dabrafenib, is a safe and effective treatment for thyroid cancer.

carcinoma
primary tumor
measurable disease
tumor growth
  • 0 views
  • 10 May, 2022
  • 7 locations
Thermal Ablation of Cervical Metastases From Thyroid Carcinoma

This study will evaluate the clinical response and safety of ultrasound guided percutaneous thermal ablation of lymph node metastases from thyroid carcinoma as an alternative to surgical

  • 0 views
  • 07 Mar, 2021
  • 1 location
Lateral Neck Lymph Node Mapping in Thyroid Cancer

This study includes papillary thyroid cancer patients who have unpalpable lateral neck lymph nodes but suspicious on ultrasound and/or CT. Carbon nanoparticles is used as the tracer for lateral

papillary thyroid carcinoma
cancer
neck dissection
  • 16 views
  • 02 Mar, 2022
  • 1 location
Vemurafenib Plus Copanlisib in Radioiodine-Refractory (RAIR) Thyroid Cancers

therapy work better in patients with BRAF-mutant thyroid cancers.

measurable disease
cancer
external beam radiation therapy
primary tumor
avid
  • 0 views
  • 17 Mar, 2022
  • 7 locations