Filter By
Clear all Advanced
I am/have/had
added new label for I am/have/had
more
I am looking for
added new label for I am looking for
more
Advanced Filters
Found 38 clinical trials
None
A Study of XmAb 20717 in Subjects With Selected Advanced Solid Tumors

This is a Phase 1, multiple dose, ascending dose escalation study to define a MTD/RD and regimen of XmAb20717, to describe safety and tolerability, to assess PK and immunogenicity, and to preliminarily assess anti-tumor activity of XmAb20717 in subjects with selected advanced solid tumors.

solid tumour
solid tumors
estrogen receptor
adenocarcinoma of prostate
neuroendocrine carcinoma
  • 421 views
  • 10 May, 2021
  • 17 locations
None
Prospective Exploratory Study of FAPi PET/CT With Histopathology Validation in Patients With Various Cancers

This exploratory study investigates how an imaging technique called 68Ga-FAPi-46 PET/CT can determine where and to which degree the FAPI tracer (68Ga-FAPi-46) accumulates in normal and cancer tissues in patients with cancer. Because some cancers take up 68Ga-FAPi-46 it can be seen with PET. FAP stands for Fibroblast Activation Protein. …

hematologic malignancy
bladder cancer
testicular
pet/ct scan
pet scan
  • 0 views
  • 23 Jul, 2021
  • 1 location
None
Oral TrkA Inhibitor VMD-928 for Treatment of Advanced Adult Solid Tumors or Lymphoma

This is a multicenter, open-label, Phase 1 study of orally administered VMD-928 in adult subjects with advanced solid tumors or lymphoma that have progressed or are non responsive to available therapies and for which no standard or available curative therapy exists

solid tumour
cancer chemotherapy
cancer
carcinoma
squamous cell carcinoma
  • 40 views
  • 25 Mar, 2021
  • 5 locations
None
Study of SO-C101 and SO-C101 in Combination With Pembro in Adult Patients With Advanced/Metastatic Solid Tumors

A multicenter open-label phase 1/1b study to evaluate the safety and preliminary efficacy of SO-C101 as monotherapy and in combination with pembrolizumab in patients with selected advanced/metastatic solid tumors

solid tumour
neuropathy
solid tumors
cancer chemotherapy
chemotherapy regimen
  • 43 views
  • 29 Apr, 2021
  • 4 locations
None
Selective Treatment According to Molecular Subtype of Prostate Cancer

This is an open-label study that includes three substudies of random distribution. First, a sample of the primary tumor will be obtained and will be analyzed by an immunohistochemical technique to determine several markers. Depending on the expression of these markers, the patients will be characterize as group 1 (Luminal …

serum testosterone
testosterone
  • 1 views
  • 22 Jan, 2021
  • 1 location
None
Sirolimus Treatment for Newly Diagnosed Primary Acquired PRCA

Pure red cell aplasia (PRCA) is a kind of anemia characterized by severe reticulocytopenia and obvious bone marrow erythroblastic cells decreased. Cyclosporine A and /or steroids are the first line therapy but some patients were refractory or intolerance to the treatment. The effects of the second line therapy are also …

  • 0 views
  • 17 Jul, 2021
  • 1 location
None
Durvalumab in Combination With Tremelimumab in Subjects With Advanced Rare Solid Tumors

This is an investigator initiated single institution, open-label study to evaluate the antitumor activity, safety, and tolerability of durvalumab in combination with tremelimumab in subjects with select advanced rare solid tumors.

primary cancer
solid neoplasm
solid tumour
metastasis
platelet count
  • 54 views
  • 16 Oct, 2021
  • 1 location
None
Metabolic Therapy Program In Conjunction With Standard Treatment For Glioblastoma Multiforme

Glioblastoma multiforme (GBM), a very aggressive brain tumour, is one of the most malignant of all cancers and is associated with a poor prognosis. The majority of GBM cells display damaged mitochondria (the "batteries" of cells), so they rely on an alternate method for producing energy called the Warburg Effect, …

cancer
dexamethasone
  • 0 views
  • 10 Jun, 2021
  • 1 location
None
Tissue Procurement and Natural History Study of Patients With Malignant Mesothelioma

Background Malignant mesothelioma is a malignancy arising from the mesothelial cells of the pleura, peritoneum, pericardium, or tunica vaginalis. Mesothelioma accounts for 0.10% of deaths annually in the United States. Malignant pleural mesothelioma is the most common of these, comprising of 80% of the cases with an annual incidence of …

vaginalis
thymic carcinoma
cell cultures
cancer
malignant mesothelioma
  • 15 views
  • 08 Dec, 2021
  • 1 location
None
The Registry of Oncology Outcomes Associated With Testing and Treatment

This study is to collect and validate regulatory-grade real-world data (RWD) in oncology using the novel, Master Observational Trial construct. This data can be then used in real-world evidence (RWE) generation. It will also create reusable infrastructure to allow creation or affiliation with many additional RWD/RWE efforts both prospective and …

primary cancer
lab tests
diagnostic procedures
  • 0 views
  • 22 Oct, 2021
  • 1 location