Filter By
Clear all Advanced
I am/have/had
added new label for I am/have/had
more
I am looking for
added new label for I am looking for
more
Advanced Filters
Found 38 clinical trials
None
A Study of KN046 in Patients With Thymic Carcinoma Who Failed Immune Checkpoint Inhibitors

This study will assess the safety and efficacy of the study drug KN046 in patients with advanced thymic carcinoma who progressed after prior treatment with immune checkpoint inhibitor therapy

carcinoma
metastasis
liver metastasis
measurable disease
progressive disease
  • 0 views
  • 01 Dec, 2021
  • 1 location
None
Carboplatin and Paclitaxel With or Without Ramucirumab in Treating Patients With Locally Advanced Recurrent or Metastatic Thymic Cancer That Cannot Be Removed by Surgery

This randomized phase II trial studies how well carboplatin and paclitaxel with or without ramucirumab work in treating patients with thymic cancer that has spread to other places in the body, has come back, or cannot be removed by surgery. Drugs used in chemotherapy, such as carboplatin and paclitaxel, work …

  • 117 views
  • 27 Jan, 2021
  • 249 locations
None
Phase I/II Eval Safety & Prelim Activity Nivolumab Comb W/Vorolanib Pts W/Refractory Thoracic Tumors

, and thymic carcinoma.

carcinoma
bilateral oophorectomy
metastasis
nivolumab
gilbert's syndrome
  • 29 views
  • 27 Sep, 2021
  • 7 locations
None
The Curative Effect of Extended Thymectomy Performed Through Subxiphoid-right VATS Approach With Elevation of Sternum

Extended thymectomy is the main treatment for thymoma and other anterior mediastinal diseases. Video-assisted thoracic surgery(VATS) plays an important role in the surgery of extended thymectomy

thymectomy
mediastinal diseases
thymus hyperplasia
thymic neoplasm
vats
  • 21 views
  • 15 May, 2021
  • 4 locations
None
Study on Proton Radiotherapy of Thymic Malignancies

This is a multicentre non-randomized phase II study of proton beam radiotherapy in patients with thymic epithelial tumours (i.e. thymoma and thymic carcinoma) in the post-operative setting or in

  • 0 views
  • 04 Apr, 2021
  • 3 locations
None
177Lu-DOTA-TATE and Olaparib in Somatostatin Receptor Positive Tumours

This is a phase I study of 177Lu-DOTA-TATE in combination with the PARP-inhibitor olaparib for treatment of patients with somatostatin receptor positive tumours detected by 68Ga-DOTA-TATE/TOC PET. The combination of a PARP inhibitor that will specifically target the repair mechanism, with ionising radiation causing SSB's might overcome the repair dependent …

olaparib
bilateral oophorectomy
metastasis
hysterectomy
somatostatin
  • 20 views
  • 25 Jan, 2021
  • 1 location
None
A Phase 1 Open-Label Dose-Escalation Study Evaluating the Safety Pharmacokinetics and Clinical Effects of Intravenously Administered PT-112 Injection in Subjects With Advanced Solid Tumors and Subsequent Dose Expansion Cohorts

Escalation Phase is no longer enrolling. The Dose Expansion Phase has two cohorts: one cohort for the study of PT-112 in patients with thymoma and thymic carcinoma, and one cohort for the study of PT

carcinoma
solid tumor
primary cancer
  • 5 views
  • 02 Dec, 2021
  • 11 locations
None
Embedded Palliative Care in Managing Symptoms in Participants With Recurrent Stage III-IV Thoracic Malignancies and Their Caregivers

This trial studies how well embedded palliative care works in managing symptoms in participants with stage III-IV thoracic malignancies that has come back and their caregivers. Embedded palliative care may improve distress and anxiety in participants and caregivers.

  • 0 views
  • 27 Jan, 2021
  • 1 location
None
Bosutinib in Combination With Pemetrexed in Patients With Selected Metastatic Solid Tumors

This study will determine the maximum-tolerated dose (MTD) for oral bosutinib when used in combination with pemetrexed. The MTD is the highest dose of bosutinib with pemetrexed that can be given without causing severe side effects. This study will also test the safety of this combination and see what effects …

primary peritoneal carcinoma
vitamin b12
measurable disease
folic acid
peritoneal cancer
  • 82 views
  • 12 Aug, 2021
  • 1 location
None
Dose Escalation Study to Assess the Safety Tolerability Pharmacokinetics and Pharmacodynamics of QBS10072S

This is a multi-center, open-label, dose escalation study to determine the safety, tolerability, pharmacokinetics, pharmacodynamics, and maximum tolerated dose (MTD) of QBS10072S in patients with advanced or metastatic cancers with high LAT1 expression. The MTD of QBS10072S will be confirmed in patients with relapsed or refractory grade 4 astrocytoma.

carcinoma
thymus cancer
astrocytoma
kidney function test
kidney function tests
  • 206 views
  • 15 Mar, 2021
  • 2 locations