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Found 22 clinical trials
Reduced Toxicity Fludarabine (Flu) + Cyclophosphamide (CPM) + Rabbit Antithymocyte Globulin (rATG) Conditioning Regimen for Unrelated Donor Transplantation in Severe Aplastic Anemia (SAA)

Anti-thymocyte globulin (ATG) has been used in severe aplastic anemia as a part of the conditioning regimen. Among the many kinds of ATG preparations, thymoglobulin had been found to be

total body irradiation
aplastic anemia
neutrophil count
cell transplantation
fludarabine
  • 26 views
  • 07 Nov, 2020
  • 1 location
Low Dose Treosulfan Based Conditioning Regimen in HSCT for Nijmegen Breakage Syndrome

The aim of the current study is to evaluate the safety and efficacy of low dose treosulfan based conditioning regimen in HSCT in Nijmegen breakage syndrome

  • 0 views
  • 25 Jan, 2021
  • 1 location
Individualized Dose Study of ATG in Haploidentical Hematopoietic Stem Cell Transplantation

The purpose of this study is to determine the response and toxicity rate of two different dosages (Individualized dosage VS. fixed dosage) of ATG as a prophylaxis for acute GVHD in haploidentical peripheral blood stem cell transplantation (haplo-PBSCT).

  • 0 views
  • 12 Mar, 2021
  • 1 location
HIgh Dose Thymoglobulin Instead of Cyclosporine With a Low Dose of Thymoglobulin for GVHD Prophylaxis

The purpose of this study is to find out whether compared to our standard low dose ATG with CSA, the high dose ATG without CSA minimizes the chances of relapse and chronic GVHD, without increasing the chances of other transplant complications.

total body irradiation
fludarabine
cyclosporine
thymoglobulin
chronic graft versus host disease
  • 11 views
  • 03 Feb, 2021
  • 1 location
Thymoglobulin in Calcineurin Inhibitor and Steroid Minimization Protocol

This study has been designed to test whether using Thymoglobulin with low dose Cyclosporine and early steroid dosage reduction will minimize both kidney rejection and the development of

calcineurin inhibitor
cyclosporine
single kidney
kidney transplant
diabetes mellitus
  • 21 views
  • 07 Nov, 2020
  • 3 locations
Giving Chemotherapy for a Shortened Amount of Time Before a Stem Cell Transplantation

rATG or thymoglobulin) can have the same or fewer number of severe side effects in people with various blood cancers 30 days after they receive an allogeneic hematopoietic cell transplantation.

blast crisis
acute leukemia
fludarabine
melphalan
myeloid leukemia
  • 5 views
  • 27 Jan, 2021
  • 1 location
Risk Stratification Directed Conditioning Regimen for Haploidentical HSCT in SAA

The haplotype HSCT system including Bu(0.8mg/kg Q6hx2d)CTX(50mg/kgx4d)rATG(2.5mg/kgx4d) , established in Institute of Hematology of Peking University ,has been evaluated to be effective for acquired SAA.But some patients with high risk factors may not tolerate CTX 200mg/kg,alternative conditioning regimen including Bu/Fludarabine/dercreased CTX was studied in this trial.

aplastic anemia
severe aplastic anemia
cyclophosphamide
fludarabine
conditioning regimen
  • 0 views
  • 23 Jan, 2021
  • 1 location
Haploidentical Bone Marrow Transplantation in Sickle Cell Patients (BMT CTN 1507)

This is a Phase II, single arm, multi-center trial, designed to estimate the efficacy and toxicity of haploidentical bone marrow transplantation (BMT) in patients with sickle cell disease (SCD). Based on their age and entry criteria patients are stratified into two groups: (1) children with SCD with strokes; and (2) …

analgesia
anti-thymocyte globulin
priapism
chest syndrome
fludarabine
  • 201 views
  • 24 Jan, 2021
  • 28 locations
Study of Intensity Modulated Total Marrow Irradiation (IM-TMI) in Addition to Fludarabine/Busulfan Conditioning for Allogeneic Transplantation in High Risk AML and Myelodysplastic Syndromes

The study is a Phase II clinical trial. Patients will receive intensity modulated total marrow irradiation (TMI) at a dose of 9 Gy with standard myeloablative fludarabine/ i.v. targeted busulfan (FluBu) conditioning prior to allogeneic hematopoietic stem cell transplant (HSCT).

tacrolimus
secondary acute myeloid leukemia
flt3 internal tandem duplication
remission
hla-a
  • 6 views
  • 24 Feb, 2021
  • 1 location
PK Study in Diabetic Transplant r cipients : From Twice-daily Tacrolimus to Once-daily Extended-release Tacrolimus

The investigators believe that the pharmacological properties of Envarsus, well studied in kidney transplantation, may be also suitable after simultaneous kidney and pancreas transplantation than Prograf. Indeed, Envarsus has demonstrated a clinical efficacy and safety in a complete clinical development plan. This study is to establish the pharmacokinetic profile of …

immunosuppressants
tacrolimus
end-stage renal disease
kidney transplant
immunosuppressive agents
  • 0 views
  • 25 Jan, 2021
  • 1 location