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Found 17 clinical trials
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Study on Proton Radiotherapy of Thymic Malignancies

This is a multicentre non-randomized phase II study of proton beam radiotherapy in patients with thymic epithelial tumours (i.e. thymoma and thymic carcinoma) in the post-operative setting or in inoperable patients with localized disease. Patients not willing or for any reason unsuitable to undergo proton treatment will be asked to …

  • 0 views
  • 04 Apr, 2021
  • 3 locations
None
Adjuvant Radiotherapy for Stage II/III Thymoma After Complete Resection

This study is designed to investigate whether adjuvant radiotherapy after complete resection has a better survival for stage II or III thymoma.

renal function
thymic neoplasm
  • 10 views
  • 22 Jan, 2021
  • 1 location
None
Postoperative Conformal Radiotherapy for Stage II-III B Type Thymoma

The purpose of this study is to determine whether postoperative conformal radiotherapy are effective in the treatment of Masaoka stage II-III B type thymoma.

thymic neoplasm
  • 10 views
  • 24 Jan, 2021
  • 1 location
None
A Pilot Study to Investigate the Safety and Clinical Activity of Avelumab (MSB0010718C) in Thymoma and Thymic Carcinoma After Progression on Platinum-Based Chemotherapy

Background Thymoma and thymic carcinoma are cancers originating in the thymus gland. Platinum-based chemotherapy is standard treatment for them. But not uncommonly, the disease returns and people need more treatment to keep the cancer from growing. The drug Avelumab could help the immune system fight cancer. Objective To test if …

chemotherapy regimen
pd-l1
measurable disease
benadryl
thymic neoplasm
  • 56 views
  • 15 Dec, 2021
  • 1 location
None
Ramucirumab and Carbo-Paclitaxel for Untreated Thymic Carcinoma / B3 Thymoma With Carcinoma (RELEVENT)

This is a multicentric study. All patients with TET (thymic epithelial tumors) of any histological type will participate in the study. This is an open-label phase 2 study that will follow a Green-Dahlberg 2-stage design whose objective is to evaluate the activity and safety of the combination of ramucirumab (10 …

liver metastasis
measurable disease
aptt
renal function
warfarin
  • 35 views
  • 26 Jan, 2021
  • 1 location
None
Carboplatin and Paclitaxel With or Without Ramucirumab in Treating Patients With Locally Advanced, Recurrent, or Metastatic Thymic Cancer That Cannot Be Removed by Surgery

This randomized phase II trial studies how well carboplatin and paclitaxel with or without ramucirumab work in treating patients with thymic cancer that has spread to other places in the body

  • 117 views
  • 17 Jan, 2022
  • 249 locations
None
The Curative Effect of Extended Thymectomy Performed Through Subxiphoid-right VATS Approach With Elevation of Sternum

Extended thymectomy is the main treatment for thymoma and other anterior mediastinal diseases. Video-assisted thoracic surgery(VATS) plays an important role in the surgery of extended thymectomy. Now, VATS thymectomy through intercostal approach has been the commonly used minimally invasive surgical procedure for thymus surgery and is applied worldwide. But the …

mediastinal diseases
anterior mediastinum
thymus hyperplasia
thymoma
thymectomy
  • 21 views
  • 15 May, 2021
  • 4 locations
None
177Lu-DOTA-TATE and Olaparib in Somatostatin Receptor Positive Tumours

This is a phase I study of 177Lu-DOTA-TATE in combination with the PARP-inhibitor olaparib for treatment of patients with somatostatin receptor positive tumours detected by 68Ga-DOTA-TATE/TOC PET. The combination of a PARP inhibitor that will specifically target the repair mechanism, with ionising radiation causing SSB's might overcome the repair dependent …

chemotherapy regimen
liver metastasis
ki-67
somatostatin
tetraxetan
  • 20 views
  • 25 Jan, 2021
  • 1 location
None
Bintrafusp Alfa (M7824) in Subjects With Thymoma and Thymic Carcinoma

thymoma and thymic carcinoma. Eligibility People age 18 and older who have thymoma or thymic cancer and their disease returned or progressed after treatment with at

  • 1 views
  • 05 Jan, 2022
  • 1 location
None
Bosutinib in Combination With Pemetrexed in Patients With Selected Metastatic Solid Tumors

This study will determine the maximum-tolerated dose (MTD) for oral bosutinib when used in combination with pemetrexed. The MTD is the highest dose of bosutinib with pemetrexed that can be given without causing severe side effects. This study will also test the safety of this combination and see what effects …

bosutinib
solid tumors
pleural mesothelioma
cancer of the ovary
lung carcinoma
  • 82 views
  • 12 Aug, 2021
  • 1 location