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Found 748 clinical trials
ATHN 8: Previously Untreated Patients (PUPs) Matter Study

This is a multi-center cohort study of approximately 250 previously untreated patients (PUPs) with congenital moderate to severe hemophilia A or B in a network of up to 50 US Hemophilia Treatment Centers (HTCs). Participants will be followed as they receive their first 50 exposure days (ED) to clotting factor …

bleeding tendency
severe haemophilia a
antihemophilic factor
christmas disease
coagulation factor
  • 02 Mar, 2022
  • 7 locations
Cardiac Neuromodulation for Heart Failure

This investigation will evaluate the ability of the Moderato® System to safely and effectively deliver CNT, to reduce sympathetic activity in heart failure patients

  • 04 Oct, 2022
  • 1 location
Near-infrared Spectroscopy for Monitoring Tissue Oxygenation in Breast Reconstruction

The study will evaluate the use of near infrared spectrometry (NIRS)in detecting early microvascular complications in deep inferior epigastric artery perforator (DIEP)-flap(s).

near-infrared spectroscopy
bilateral breast reconstruction
breast reconstruction
  • 01 Feb, 2022
  • 1 location
Cardiovascular Risk Factors , Complications and Threputic Management Strategies in Patients With Coronary Heart Disease and COVID 19

Using INTERASPIRE model to determine patients with established CHD whether the guidelines on cardiovascular disease prevention are being followed or not with incorporation of COVID 19 as a risk factor with the other classical risk factors to understand significance of the new pandemic virus in mortality and morbidity of CVD …

secondary prevention
unstable angina
cardiovascular disease
  • 07 Oct, 2022
  • 1 location
Effect of COVID-19 on Endothelial Function

COVID-19 disease (coronavirus disease 2019) primarily affects the respiratory system, using the angiotensin-converting enzyme 2 receptor. However, there is increasing evidence that COVID-19 can also affect the heart (myocardial injury, myocarditis, arrhythmias) and the vascular system, effects that may worsen the clinical outcome of patients. The aim of this study …

Accepts healthy volunteers
  • 04 Oct, 2022
  • 1 location
The Detrimental Course of Acute Intestinal Ischemia (TACTIC)

Rationale Acute intestinal ischemia is a life-threatening condition with a short-term mortality that can range up to 80%. Medical diagnosis and treatment have remained troublesome, due to the clinical presentation which is mostly characterized by non-specific signs and symptoms. Early unambiguous diagnosis of acute intestinal ischemia is critical to prevent …

volatile organic compounds
  • 21 Mar, 2022
  • 2 locations
Early Recurrences of Atrial Arrhythmias and Their Impact on Late Recurrence After Pulmonary Vein Isolation With Pulsed Field Ablation of Paroxysmal Atrial Fibrillation

This is a prospective, single-arm study conducted in University Hospital of Split, Department of Cardiology. Patients treated with PFA for symptomatic paroxysmal atrial fibrillation will be asked to participate in the study. An implantable loop recorder (ILR) will be placed immediately after the PFA procedure for rhythm monitoring. Early recurrences …

  • 06 May, 2022
  • 1 location
Long-term Characterization of Lipoprotein Apheresis Technologies for Individual Device Adaption (LOLIDA) (LOLIDA)

Lipoprotein apheresis is often applied as the final treatment of patient with severe and medication resistant dyslipidemia and progressive atherosclerosis. The high effectiveness of lipoprotein apheresis to improve the patient's metabolic situation and thereby strongly minimize the incidence of cardiovascular events was confirmed by a variety of studies. While in …

cholesterol measurement
  • 21 Mar, 2022
Shock Testing to Unmask RV Lead and GEnerator Malfunction in ICD Patients: the SURGE-ICD Registry (Surge-ICD)

Shock testing during ICD generator replacement has been omitted by many centers. A previous study revealed lead failures in internally cardioverted patients with previously normal HV-lead values. The real prevalence of unrecognized "silent" lead failure in ICD patients remains unknown. As a consequence, patients may be equipped with an ICD …

  • 16 Jun, 2022
  • 1 location
Cardiovascular Status of Children 5 Years After Kawasaki Disease (CAVASAKI)

The aim of present study is to determine cardiovascular status of children who had KD in past and to identify possible biochemical markers of cardiovascular damage in those patients. In this cross-sectional study children with history of KD will be examined 5 years after receiving intravenous immunoglobulin treatment (IVIG) and …

circulating endothelial cells
immune globulin
  • 19 Feb, 2022
  • 1 location