Filter By
Clear all Advanced
I am/have/had
added new label for I am/have/had
more
I am looking for
added new label for I am looking for
more
Advanced Filters
Found 22 clinical trials
To Assess the Safety Tolerability and Efficacy of Itacitinib Immediate Release Tablets in Participants With Primary or Secondary Myelofibrosis Who Have Received Prior Ruxolitinib and/or Fedratinib Monotherapy (LIMBER-213)

This is a 2-part study. In Part 1, participants will be dosed at 2 different dose levels in order to select the RP2D for Part 2 of the study.

ruxolitinib
myelofibrosis
  • 0 views
  • 08 Aug, 2021
  • 12 locations
A Safety Trial of Fedratinib in Subjects With DIPSS Intermediate or High-Risk Primary Myelofibrosis Post-Polycythemia Vera Myelofibrosis or Post-Essential Thrombocythemia Myelofibrosis and Previously Treated With Ruxolitinib With Concomitant Luspatercept for Subjects With Anemia

This is Single-Arm, Open-Label Efficacy and Safety Trial of Fedratinib in Subjects with DIPSS (Dynamic International Prognostic Scoring System)-Intermediate or High- Risk Primary Myelofibrosis (PMF), Post-Polycythemia Vera Myelofibrosis (post-PV MF), or Post-Essential Thrombocythemia Myelofibrosis (post-ET MF) and Previously Treated with Ruxolitinib including a Sub-study with concomitant Luspatercept for subjects with …

thrombocytopenia
essential thrombocythemia
anemia
luspatercept
thrombocytosis
  • 72 views
  • 31 Aug, 2021
  • 41 locations
Pilot Study for the Development of a Diagnostic Score to Differentiate Myeloproliferative Neoplasms.

Prospective study for the development of a non-invasive score for differentiating prefibrotic myelofibrosis from essential thrombocytosis and overt myelofibrosis.

  • 0 views
  • 23 Jan, 2021
  • 2 locations
  • 0 views
  • 01 Apr, 2021
  • 2 locations
Azacitidine Venetoclax and Pevonedistat in Treating Patients With Newly Diagnosed Acute Myeloid Leukemia

This phase I/II trial studies the best dose of venetoclax when given together with azacitidine and pevonedistat and to see how well it works in treating patients with newly diagnosed acute myeloid leukemia. Drugs used in chemotherapy, such as azacitidine, work in different ways to stop the growth of cancer …

blood transfusion
new diagnosis
cancer
leukemia
decitabine
  • 40 views
  • 18 Mar, 2021
  • 1 location
Open-Label Efficacy and Safety Study of Pozelimab in Patients With CD55-Deficient Protein-Losing Enteropathy (CHAPLE Disease)

pozelimab on health-related quality of life To determine the effect of pozelimab on lab abnormalities observed in CD55-deficient PLE such as hypertriglyceridemia, thrombocytosis, and

  • 10 views
  • 12 Aug, 2021
  • 3 locations
Serial Measurements of Molecular and Architectural Responses to Therapy (SMMART) PRIME Trial

This phase Ib trial determines if samples from a patient's cancer can be tested to find combinations of drugs that provide clinical benefit for the kind of cancer the patient has. This study is also being done to understand why cancer drugs can stop working and how different cancers in …

enasidenib
idelalisib
tretinoin
lymphocytic leukemia
leukemia
  • 0 views
  • 26 Jul, 2021
  • 1 location
Molecular Biology of Polycythemia and Thrombocytosis

Our study is designed to characterize the clinical picture and genetic pattern of Polycythemia and Thrombocytosis. The purpose of this project is to find a gene and its mutation that causes

  • 5 views
  • 26 Jan, 2021
  • 1 location
Hematology IMG-7289 LSD1 (Lysine-Specific Demethylase 1) Inhibitor Essential Thrombocythemia (ET) Ph 2

This is a single-center, open-label investigator-initiated trial evaluating the effects of IMG-7289 administered orally once daily in patients with essential thrombocythemia.

interferon
thrombosis
hydroxyurea
thrombocytosis
neutrophil count
  • 0 views
  • 21 Jun, 2021
  • 1 location
IMG-7289 in Patients With Essential Thrombocythemia

This is a Phase 2b open label study of an orally administered LSD1 inhibitor, IMG-7289, in patients with essential thrombocythemia. This study investigates the following: The safety and tolerability of IMG-7289 The pharmacodynamic effect of IMG-7289

interferon
thrombocytosis
thrombosis
platelet count
  • 1 views
  • 31 Jul, 2021
  • 6 locations