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Found 55 clinical trials
Study to Evaluate Rilzabrutinib in Adults and Adolescents With Persistent or Chronic Immune Thrombocytopenia (ITP) (LUNA 3)

This is a randomized, double-blind study of rilzabrutinib in patients with persistent or chronic ITP, with an average platelet count of <30,000/μL (and no single platelet count >35,000/μL) on two counts at least 5 days apart in the 14 days before treatment begins. Patients will receive rilzabrutinib or placebo 400mg …

neutrophil count
thrombocytopenia
kidney function tests
igiv
platelet count
  • 9 views
  • 27 May, 2022
  • 111 locations
Basket Study to Assess Efficacy, Safety and PK of Iptacopan (LNP023) in Autoimmune Benign Hematological Disorders

The main purpose of this study is to evaluate the efficacy and safety of iptacopan in participants with autoimmune benign hematological disorders such as primary immune thrombocytopenia and primary cold agglutinin disease.

thrombocytopenia
hemolysis
anemia
  • 0 views
  • 29 Jun, 2022
  • 6 locations
The DART Study- Daratumumab Treatment in ITP

A multicenter clinical, open-label total dose-escalating phase II study with safety run-in to explore the clinical activity, total dosage, and safety of daratumumab in adult ITP patients who have not responded adequately or relapsed after corticosteroids and at least one second-line therapy including rituximab and/or TPO-RA.

steroid therapy
platelet count
corticosteroids
rituximab
  • 8 views
  • 08 Jan, 2022
  • 4 locations
The PROLONG Trial - Rituximab Maintenance Therapy in ITP

This study is a two phase study that aims to evaluate if low-dose Rituximab maintenance therapy may prolong the the effect of Rituximab in immune thrombocytopenia.

thrombocytopenia
prednisolone
platelet count
dexamethasone
prednisone
  • 157 views
  • 25 Feb, 2022
  • 1 location
Romiplostim Rituximab and Dexamethasone as Frontline Treatment for Immune Thrombocytopenia

The purpose of this study is to determine the response rate and response duration with the combination of low-dose rituximab, romiplostim and high-dose dexamethasone.

thrombocytopenia
platelet count
dexamethasone
rituximab
romiplostim
  • 0 views
  • 25 Jan, 2021
  • 1 location
Dose Dense Rituximab for High Risk Newly Diagnosed Acute Immune Thrombocytopenic Purpura

The purpose of this study is to determine if a dose dense administration of Rituximab in newly diagnosed acute immune thrombocytopenic purpura (ITP) and determine relapse rate following this

platelet count
kidney function tests
KIT
prednisone
eltrombopag
  • 0 views
  • 14 Aug, 2021
  • 1 location
Comparative Study of Clinical Efficacy and Safety of GNR-069 and Nplate in Patients With Chronic ITP

It is a phase III multicenter randomized double-blinded comparative study of clinical efficacy and safety of GNR-069 and Nplate in patients with chronic idiopathic thrombocytopenic purpura

thrombocytopenia
splenectomy
platelet count
igiv
azathioprine
  • 0 views
  • 25 Mar, 2022
  • 2 locations
to Evaluate the Efficacy and Safety of Eltrombopag for Thrombocytopenia With Chronic HBV Infection

Primary Objective: To evaluate the efficacy of 6-week Eltrombopag to treat thrombocytopenia associated with chronic hepatitis B virus infection. Secondary Objective: To evaluate the efficacy and safety of 6-week and 22-week Eltrombopag to treat thrombocytopenia associated with chronic hepatitis B virus infection.

  • 0 views
  • 10 Jul, 2021
  • 1 location
The Efficacy and Safety of Huaiqihuang Granule in Children With Chronic Primary Immune Thrombocytopenia (ITP)

This is a multisite, double-blind, randomized, placebo-controlled, and parallel study designed to evaluate the clinical efficacy and safety of Huaiqihuang granule for treatment to children with chronic primary immune thrombocytopenia (Qi Yin deficiency).

thrombocytopenia
anemia
autoimmune disease
initial diagnosis
autoimmune thrombocytopenia
  • 0 views
  • 13 Mar, 2022
  • 14 locations
Eltrombopag vs Standard Front Line Management for Newly Diagnosed Immune Thrombocytopenia (ITP) in Children

This is an investigator initiated, multicenter, open label, randomized phase 3 study for subjects with newly diagnosed ITP from ages 1 to less than 18 years old.

thrombocytopenia
intravenous immunoglobulin
autoimmune thrombocytopenia
immune globulin
immunoglobulins
  • 10 views
  • 06 Feb, 2022
  • 11 locations