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Found 58 clinical trials
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Eltrombopag Added to Standard Immunosuppression in Treatment-Naive Severe Aplastic Anemia

Background: Severe aplastic anemia is a rare and serious blood disorder. It happens when the immune system starts to attack the bone marrow cells. This causes the bone marrow to stop making red blood cells, platelets, and white blood cells. Standard treatment for this disease is horse-ATG and cyclosporine, which …

myelodysplastic syndromes
aplastic anemia
anemia
anemia studies
myelodysplastic syndrome (mds)
  • 172 views
  • 22 Dec, 2020
  • 1 location
A Study of BAX 930 in Children, Teenagers, and Adults Born With Thrombotic Thrombocytopenic Purpura (TTP)

Thrombotic thrombocytopenic purpura (or TTP for short) is a condition where blood clots form in small blood vessels throughout the body. The clots can limit or block the flow of oxygen-rich

  • 21 views
  • 25 Mar, 2022
  • 30 locations
A Study of TAK-755 in Participants With Congenital Thrombotic Thrombocytopenic Purpura

Thrombotic thrombocytopenic purpura (or TTP for short) is a condition where blood clots form in small blood vessels throughout the body. The clots can limit or block the flow of oxygen-rich

  • 6 views
  • 23 Apr, 2022
  • 8 locations
A Clinical Study on the Efficacy and Safety of HBM9161 in Patients With ITP

To select a dose and to make a decision for Phase 3 study

  • 0 views
  • 17 Feb, 2021
  • 1 location
A Single Arm Study of Brain Metastasis in Patients With HER2-positive Breast Cancer

The aim of this study was to evaluate the progression time and efficacy of brain tumors in patients with brain metastases from HER2-positive breast cancer treated with Pyrrolidine and Capecitabine combined with brain radiotherapy.

  • 3 views
  • 03 Mar, 2021
  • 1 location
Platelet Augmentation Using C. Papaya Leaf Extract in Live Donor Liver Transplantation

live donor liver transplant recipients. Carica Papaya leaf extract has shown positive results in increasing platelet counts in various medical conditions such as Dengue, Immune thrombocytopenic purpura

  • 0 views
  • 09 May, 2022
  • 1 location
Eltrombopag+hATG+CsA vs. hATG+CsA in Children With Severe AA

The analysis of our own clinical data suggests that majority of the hematologic responses observed after the course of h-ATG/CsA is partial, and about 10% tend to have cyclosporine dependence. The aim of the current study is to improve the rate and the quality of hematologic response as well as …

  • 45 views
  • 26 Feb, 2022
  • 1 location
A Study of PRN1008 in Adult Patients With Immune Thrombocytopenia (ITP)

This is a 2 part (Part A and B) adaptive, open-label, dose-finding study of PRN1008 in patients with ITP who are refractory or relapsed with no available and approved therapeutic options, with a platelet count <30,000/μL on two counts no sooner than 7 days apart in the 15 days before …

autoimmune thrombocytopenia
platelet count
thrombocytopenia
  • 455 views
  • 12 Mar, 2022
  • 28 locations
Study to Evaluate Rilzabrutinib in Adults and Adolescents With Persistent or Chronic Immune Thrombocytopenia (ITP) (LUNA 3)

This is a randomized, double-blind study of rilzabrutinib in patients with persistent or chronic ITP, with an average platelet count of <30,000/μL (and no single platelet count >35,000/μL) on two counts at least 5 days apart in the 14 days before treatment begins. Patients will receive rilzabrutinib or placebo 400mg …

igiv
platelet count
kidney function tests
neutrophil count
thrombocytopenia
  • 34 views
  • 09 Apr, 2022
  • 95 locations
Avatrombopag for the Treatment of Thrombocytopenia in Pediatric Subjects With Immune Thrombocytopenia for ≥6 Months

A Phase 3b Study to Evaluate the Efficacy and Safety of Avatrombopag for the Treatment of Thrombocytopenia in Pediatric Subjects with Immune Thrombocytopenia for ≥6 Months

avatrombopag
thrombocytopenia
  • 13 views
  • 29 Apr, 2022
  • 25 locations