Filter By
Clear all Advanced
I am/have/had
added new label for I am/have/had
more
I am looking for
added new label for I am looking for
more
Advanced Filters
Found 37 clinical trials
The EndRAD Trial: Eliminating Total Body Irradiation (TBI) for NGS-MRD Negative Children Adolescents and Young Adults With B-ALL

This study will evaluate the use of non- TBI (total body irradiation) conditioning for B-ALL patients with low risk of relapse as defined by absence of NGS-MRD (next generation sequencing minimal residual disease) before receiving a hematopoietic cell transplant (HCT). Patients diagnosed with B-ALL who are candidates for HCT will …

blinatumomab
residual tumor
shortening fraction
gilbert's syndrome
stem cell transplantation
  • 14 views
  • 31 Aug, 2021
  • 24 locations
Graft Versus Host Disease-Reduction Strategies for Donor Blood Stem Cell Transplant Patients With Acute Leukemia

This phase II trial investigates three strategies and how well they work for the reduction of graft versus host disease in patients with acute leukemia in remission. Giving chemotherapy and total-body irradiation before a donor peripheral blood stem cell transplant helps stop the growth of cells in the bone marrow, …

total body irradiation
tacrolimus
leukemia
blood cell count
hla-a
  • 3 views
  • 08 May, 2021
  • 3 locations
Conditioning SCID Infants Diagnosed Early

The investigators want to study if lower doses of chemotherapy will help babies with SCID to achieve good immunity with less short and long-term risks of complications after transplantation. This trial identifies babies with types of immune deficiencies that are most likely to succeed with this approach and offers them …

  • 0 views
  • 23 Sep, 2021
  • 20 locations
Autologous Stem Cell Transplantation in Patients With Systemic Sclerosis

The purpose of this study is to determine whether a regimen of high-dose immunoablative therapy will demonstrate safety that is consistent or improved with other published regimens in SSc patients, while maintaining a treatment effect. We also hypothesize that our mechanistic studies will yield biomarkers that may herald disease recurrence …

total body irradiation
MRSS
ct scan
mesna
progressive systemic sclerosis
  • 176 views
  • 27 Jan, 2021
  • 2 locations
Acute GVHD Suppression Using Costimulation Blockade to Expand Non-malignant Transplant

The ASCENT Trial is a single arm, multi-center, phase II study. The primary objective is to determine the rejection-free, severe graft-versus-host disease (GVHD)-free survival in pediatric patients with serious non-malignant hematologic diseases (NMHD) undergoing unrelated donor (URD) hematopoietic stem cell transplantation (HSCT) with abatacept added to conventional GVHD prophylaxis. The …

tacrolimus
blood disorder
stroke
acute graft-versus-host disease
anemia
  • 4 views
  • 19 Aug, 2021
  • 7 locations
Study of Thiotepa and TEPA Drug Exposure in Pediatric Hematopoietic Stem Cell Transplant Patients

Thiotepa is a chemotherapy drug used extensively in bone marrow transplantation. Thiotepa is a prodrug that undergoes metabolic conversion in the liver by CYP2B6 and CYP3A4 to its primary active

chemotherapy drug
thiotepa
stem cell transplantation
drug levels
tepa
  • 32 views
  • 26 Jan, 2021
  • 1 location
Data Collection Study of Patients With Non-Malignant Disorders Undergoing UCBT BMT or PBSCT With RIC

This is a data collection study that will examine the general diagnostic and treatment data associated with the reduced-intensity chemotherapy-based regimen paired with simple alemtuzumab dosing strata designed to prevented graft failure and to aid in immune reconstitution following hematopoietic stem cell transplantation.

  • 0 views
  • 27 Sep, 2021
  • 1 location